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Topamax Side Effects

Common Topamax Side Effects


The most commonly reported Topamax side effects (click to view or check a box to report):

Convulsion (270)
Weight Decreased (237)
Headache (193)
Paraesthesia (148)
Confusional State (148)
Depression (147)
Dizziness (146)
Vision Blurred (139)
Self Injurious Behaviour (139)
Fatigue (127)
Nausea (118)
Angle Closure Glaucoma (113)
Dyspnoea (113)
Anxiety (113)
Disturbance In Attention (109)
Intentional Overdose (101)
Loss Of Consciousness (98)
Insomnia (97)
Migraine (95)
Hypoaesthesia (93)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Topamax Side Effects Reported to FDA

The following Topamax reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Topamax on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Self Injurious Behaviour, Hypotension, Tachycardia, Sopor
This is a report of a 50-year-old female patient (weight: NA) from IT, suffering from the following symptoms/conditions: NA, who was treated with Topamax (dosage: NA, start time: Mar 01, 2014), combined with:
  • Clozapine
  • Lorazepam
  • Anafranil
and developed a serious reaction and side effect(s). The consumer presented with:
  • Self Injurious Behaviour
  • Hypotension
  • Tachycardia
  • Sopor
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Topamax treatment in female patients, resulting in self injurious behaviour side effect.

Convulsion
This report suggests a potential Topamax Convulsion side effect(s) that can have serious consequences. A 46-year-old female patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Topamax (dosage: NA) starting NS. Soon after starting Topamax the patient began experiencing various side effects, including:
  • Convulsion
Drugs used concurrently: NA. Although Topamax demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as convulsion, may still occur.

Febrile Convulsion, Body Temperature Increased, Skin Exfoliation, Anhidrosis, Lip Exfoliation
This Febrile Convulsion, Body Temperature Increased, Skin Exfoliation, Anhidrosis, Lip Exfoliation problem was reported by a health professional from BR. A 2-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: aggression,convulsion. On NS this consumer started treatment with Topamax (dosage: NA). The following drugs were being taken at the same time: NA. When commencing Topamax, the patient experienced the following unwanted symptoms/side effects:
  • Febrile Convulsion
  • Body Temperature Increased
  • Skin Exfoliation
  • Anhidrosis
  • Lip Exfoliation
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as febrile convulsion, may become evident only after a product is in use by the general population.

Self Injurious Behaviour, Intentional Overdose, Hypotension, Sluggishness
This is a report of a 28-year-old female patient (weight: NA) from IT. The patient developed the following symptoms/conditions: NA and was treated with Topamax (dosage: 50 Mg) starting Feb 20, 2014. Concurrently used drugs:
  • Minias
  • Abilify
Soon after that, the consumer experienced the following side effects:
  • Self Injurious Behaviour
  • Intentional Overdose
  • Hypotension
  • Sluggishness
This opens a possibility that Topamax treatment could cause the above reactions, including self injurious behaviour, and some female subjects may be more susceptible.


Suicidal Ideation, Arthritis, Off Label Use
A female patient (weight: NA) from US with the following symptoms/conditions: libido increased started Topamax treatment (dosage: NA) on 2011. Soon after starting Topamax treatment, the subject experienced various side effects, including:
  • Suicidal Ideation
  • Arthritis
  • Off Label Use
Concurrently used drugs: NA. This finding indicates that some female patients could be more vulnerable to Topamax.

Depression, Dyspnoea, Cognitive Disorder, Emotional Disorder, Rash
A 49-year-old female patient from US (weight: NA) experienced symptoms, such as: NA and was treated with Topamax(dosage: Current - See Below??2 Tablets Twice Daily). The treatment was initiated on NS. After that a consumer reported the following side effect(s):
  • Depression
  • Dyspnoea
  • Cognitive Disorder
  • Emotional Disorder
  • Rash
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Topamax efficacy: NA.

Bone Pain
In this report, Topamax was administered for the following condition: back pain.A 55-year-old male consumer from US (weight: NA) started Topamax treatment (dosage: NA) on NS.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Bone Pain
A possible interaction with other drugs could have contributed to this reaction:
  • Tramadol
Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Topamax treatment could be related to the listed above side effect(s).

Epilepsy, Abortion Spontaneous, Nasopharyngitis, Exposure During Pregnancy
This is a report of the following Topamax side effect(s):
  • Epilepsy
  • Abortion Spontaneous
  • Nasopharyngitis
  • Exposure During Pregnancy
A 30-year-old female patient from CN (weight: NA) presented with the following condition: epilepsy and received a treatment with Topamax (dosage: NA) starting: NS.The following concurrently used drugs could have generated interactions: NA.This report suggests that a Topamax treatment could be associated with the listed above side effect(s).

Product Substitution Issue, Headache, Weight Increased
This Topamax report was submitted by a male consumer from US (weight: NA). The patient was diagnosed with: NA and Topamax was administered (dosage: NA) starting: NS. The consumer developed a set of symptoms:
  • Product Substitution Issue
  • Headache
  • Weight Increased
Other drugs used simultaneously: NA.Those unexpected symptoms could be linked to a Topamax treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Epilepsy
This is a report of a possible correlation between Topamax use and the following symptoms/side effect(s):
  • Epilepsy
which could contribute to an assessment of Topamax risk profile.A 8-year-old male consumer from RU (weight: NA) was suffering from NA and was treated with Topamax (dosage: NA) starting NS.Other concurrent medications:
  • Lamotrigine


Psychotic Disorder
A female patient from US (weight: NA) presented with the following symptoms: epilepsy and after a treatment with Topamax (dosage: NA) experienced the following side effect(s):
  • Psychotic Disorder
The treatment was started on NS. Topamax was used in combination with the following drugs: NA.This report could alert potential Topamax consumers.

Amnesia, Migraine
In this report, a 58-year-old female patient from US (weight: NA) was affected by a possible Topamax side effect.The patient was diagnosed with NA. After a treatment with Topamax (dosage: NA, start date: NS), the patient experienced the following side effect(s):
  • Amnesia
  • Migraine
The following simultaneously used drugs could have led to this reaction: NA.The findings here stress that side effects should be taken into consideration when evaluating a Topamax treatment.

Convulsion, Renal Pain, Nephrolithiasis, Haemorrhage
This is a report of a female patient from US (weight: NA), who used Topamax (dosage: NA) for a treatment of convulsion. After starting a treatment on 1998, the patient experienced the following side effect(s):
  • Convulsion
  • Renal Pain
  • Nephrolithiasis
  • Haemorrhage
The following drugs could possibly have interacted with the Topamax treatment NA.The patient was hospitalized.Taken together, these observations suggest that a Topamax treatment could be related to side effect(s), such as Convulsion, Renal Pain, Nephrolithiasis, Haemorrhage.

Myoclonic Epilepsy
This myoclonic epilepsy side effect was reported by a health professional from RU. A 29-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA. The patient was prescribed Topamax (dosage: NA), which was started on NS. Concurrently used drugs: NA. When starting to take Topamax the consumer reported the following symptoms:
  • Myoclonic Epilepsy
These side effects may potentially be related to Topamax.

Gastric Bypass
This is a Topamax side effect report of a female patient (weight:NA) from US, suffering from the following symptoms/conditions: NA, who was treated with Topamax (dosage:NA, start time: NS), combined with:
  • Synthroid
  • Morphine Sulphate
  • Clonazepam
, and developed a serious reaction and a gastric bypass side effect. The patient presented with:
  • Gastric Bypass
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Topamax treatment in female patients suffering from NA, resulting in gastric bypass.

Conjunctivitis
This report suggests a potential Topamax conjunctivitis side effect(s) that can have serious consequences. A 34-year-old female patient from US (weight:NA) was diagnosed with the following health condition(s): migraine and used Topamax (dosage: NA) starting Jan 14, 2014. Soon after starting Topamax the patient began experiencing various side effects, including:
  • Conjunctivitis
Drugs used concurrently:NA. Although Topamax demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as conjunctivitis, may still occur.

Mood Swings, Hypoaesthesia, Vision Blurred, Visual Acuity Reduced Transiently, Dry Eye, Catatonia, Dehydration
This mood swings problem was reported by a consumer or non-health professional from US. A 44-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): headache,prophylaxis.On Dec 03, 2013 a consumer started treatment with Topamax (dosage: NA). The following drugs/medications were being taken at the same time: NA. When commencing Topamax, the patient experienced the following unwanted symptoms /side effects:
  • Mood Swings
  • Hypoaesthesia
  • Vision Blurred
  • Visual Acuity Reduced Transiently
  • Dry Eye
  • Catatonia
  • Dehydration
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as mood swings, may become evident only after a product is in use by the general population.

Epilepsy
This is a Topamax side effect report of a 25-year-old female patient (weight: NA) from RU. The patient developed the following symptoms/conditions: NA and was treated with Topamax (dosage: NA) starting NS. Concurrently used drugs: NA. Soon after that, the consumer experienced the following of symptoms:
  • Epilepsy
This opens a possibility that Topamax could cause epilepsy and that some female patients may be more susceptible.

Urticaria, Hepatotoxicity
A 41-year-old female patient (weight: NA) from RU with the following symptoms: NA started Topamax treatment (dosage: NA) on NS. Soon after starting Topamax treatment, the consumer experienced several side effects, including:
  • Urticaria
  • Hepatotoxicity
. Concurrently used drugs:
  • Phenobarbital
  • Valproic Acid
The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Topamax side effects, such as urticaria.

Epilepsy
This epilepsy side effect was reported by a physician from RU. A 8-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Topamax (dosage: NA), which was started on NS. Concurrently used drugs: NA..When starting to take Topamax the consumer reported symptoms, such as:
  • Epilepsy
These side effects may potentially be related to Topamax.

Psychomotor Hyperactivity, Weight Decreased, Dyspepsia, Affect Lability, Headache
This is a report of a 11-year-old female patient (weight: NA) from RU, suffering from the following symptoms/conditions: NA, who was treated with Topamax (dosage: NA, start time: NS), combined with:
  • Convulex (valproic Acid)
and developed a serious reaction and side effect(s). The consumer presented with:
  • Psychomotor Hyperactivity
  • Weight Decreased
  • Dyspepsia
  • Affect Lability
  • Headache
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Topamax treatment in female patients, resulting in psychomotor hyperactivity side effect.

Weight Decreased, Nausea, Vomiting, Eating Disorder
This report suggests a potential Topamax Weight Decreased, Nausea, Vomiting, Eating Disorder side effect(s) that can have serious consequences. A 29-year-old male patient (weight: NA) from RU was diagnosed with the following symptoms/conditions: NA and used Topamax (dosage: NA) starting NS. Soon after starting Topamax the patient began experiencing various side effects, including:
  • Weight Decreased
  • Nausea
  • Vomiting
  • Eating Disorder
Drugs used concurrently: NA. Although Topamax demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as weight decreased, may still occur.

Weight Decreased, Nausea, Vomiting, Appetite Disorder
This Weight Decreased, Nausea, Vomiting, Appetite Disorder problem was reported by a physician from RU. A 29-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Topamax (dosage: NA). The following drugs were being taken at the same time: NA. When commencing Topamax, the patient experienced the following unwanted symptoms/side effects:
  • Weight Decreased
  • Nausea
  • Vomiting
  • Appetite Disorder
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as weight decreased, may become evident only after a product is in use by the general population.

Thrombocytopenia, Uterine Haemorrhage
This is a report of a 46-year-old female patient (weight: NA) from RU. The patient developed the following symptoms/conditions: NA and was treated with Topamax (dosage: NA) starting NS. Concurrently used drugs: NA.Soon after that, the consumer experienced the following side effects:
  • Thrombocytopenia
  • Uterine Haemorrhage
The patient was hospitalized. This opens a possibility that Topamax treatment could cause the above reactions, including thrombocytopenia, and some female subjects may be more susceptible.

Epilepsy
A 22-year-old female patient (weight: NA) from RU with the following symptoms/conditions: NA started Topamax treatment (dosage: NA) on NS. Soon after starting Topamax treatment, the subject experienced various side effects, including:
  • Epilepsy
Concurrently used drugs: NA. This finding indicates that some female patients could be more vulnerable to Topamax.

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Top 10 Topamax Side Effects for Women

Women Side EffectsReports
Weight Decreased 185
Convulsion 179
Headache 155
Paraesthesia 134
Dizziness 123
Depression 121
Vision Blurred 118
Self Injurious Behaviour 116
Fatigue 109
Confusional State 102

Top 10 Topamax Side Effects for Men

Men Side EffectsReports
Convulsion 86
Weight Decreased 52
Confusional State 42
Headache 38
Disturbance In Attention 28
Insomnia 27
Nephrolithiasis 25
Depression 24
Nausea 24
Tremor 24

Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


    Discuss Topamax Side Effects

    Did You Have a Topamax Side Effect?

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    Yes, Moderate
    Yes, Minor
    No

    How Effective is Topamax for You?

    Exceeded Expectations
    Effective
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    Topamax Safety Alerts, Active Ingredients, Usage Information

    NDC21695-128
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameTopamax
    Nametopiramate
    Dosage FormTABLET, COATED
    RouteORAL
    On market since19970101
    LabelerRebel Distributors Corp
    Active Ingredient(s)TOPIRAMATE
    Strength(s)25
    Unit(s)mg/1
    Pharma ClassAnti-epileptic Agent [EPC],Decreased Central Nervous System Disorganized Electrical Activity [PE]

    Topamax Dosage, Warnings, Usage.

    Side Effects reported to FDA: 3748

    Topamax safety alerts: 2011 2005 2003 2001

    Reported deaths: 156

    Reported hospitalizations: 1102

    Topamax (topiramate): Recall - Musty Odor

    [Posted 04/15/2011]

    AUDIENCE: Risk Manager, Pharmacy, Patients

    ISSUE: Ortho-McNeil Neurologics Division of Ortho-McNeil-Janssen Pharmaceuticals, Inc., is recalling two lots of Topamax (topiramate) 100mg Tablets. The recall stems from four consumer reports of an uncharacteristic odor thought to be caused by trace amounts of TBA (2,4,6 tribromoanisole). While not considered to be toxic, TBA can generate an offensive odor and a small number of patients have reported temporary gastrointestinal symptoms. There have been no reported serious adverse events caused by the presence of TBA in Topamax.

    BACKGROUND: Topamax is indicated as initial monotherapy in patients 10 years of age and older with partial onset or primary generalized tonic-clonic seizures; as adjunctive therapy for adults and pediatric patients ages 2 − 16 years with partial onset seizures, or primary generalized tonic-clonic seizures, and in patients 2 years of age and older with seizures associated with Lennox-Gastaut syndrome; and for adults for the prophylaxis of migraine headache.

    RECOMMENDATION: Patients taking Topamax 100mg Tablets who experience an uncharacteristic odor associated with their medication should return the tablets to their pharmacist, and contact their healthcare professional if they have questions.

    Healthcare professionals and patients are encouraged to report adverse events or side effects related to the use of these products to the FDA's MedWatch Safety Information and Adverse Event Reporting Program:

    • Complete and submit the report Online: www.fda.gov/MedWatch/report.htm
    • Download form or call 1-800-332-1088 to request a reporting form, then complete and return to the address on the pre-addressed form, or submit by fax to 1-800-FDA-0178

     

    [04/14/2011 - Press Release - Ortho-McNeil]

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