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Tramadol Side Effects

Common Tramadol Side Effects


The most commonly reported Tramadol side effects (click to view or check a box to report):

Completed Suicide (483)
Toxicity To Various Agents (393)
Convulsion (331)
Nausea (320)
Vomiting (285)
Death (284)
Dizziness (268)
Confusional State (242)
Overdose (240)
Somnolence (201)
Pain (174)
Dyspnoea (165)
Headache (164)
Cardio-respiratory Arrest (159)
Hyperhidrosis (156)
Serotonin Syndrome (155)
Fall (154)
Loss Of Consciousness (142)
Intentional Overdose (139)
Hallucination (135)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Tramadol Side Effects Reported to FDA

The following Tramadol reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Tramadol on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Dizziness, Vomiting, Hyperhidrosis, Vision Blurred, Hypotension
This is a report of a 47-year-old male patient (weight: NA) from GB, suffering from the following symptoms/conditions: NA, who was treated with Tramadol (dosage: NA, start time: Feb 06, 2014), combined with:
  • Codeine Linctus (15mg/5ml)
  • Ferrous Fumarate (140mg In 5ml Linctus)
  • Omeprazole
  • Paracetamol
and developed a serious reaction and side effect(s). The consumer presented with:
  • Dizziness
  • Vomiting
  • Hyperhidrosis
  • Vision Blurred
  • Hypotension
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Tramadol treatment in male patients, resulting in dizziness side effect.

Hallucination, Pain, Sedation, Nausea, Vomiting, Treatment Noncompliance, Infection
This report suggests a potential Tramadol Hydrochloride Hallucination, Pain, Sedation, Nausea, Vomiting, Treatment Noncompliance, Infection side effect(s) that can have serious consequences. A 40-year-old male patient (weight: NA) from CA was diagnosed with the following symptoms/conditions: NA and used Tramadol Hydrochloride (dosage: NA) starting NS. Soon after starting Tramadol Hydrochloride the patient began experiencing various side effects, including:
  • Hallucination
  • Pain
  • Sedation
  • Nausea
  • Vomiting
  • Treatment Noncompliance
  • Infection
Drugs used concurrently: NA.The patient was hospitalized. Although Tramadol Hydrochloride demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as hallucination, may still occur.

Hyperkalaemia, Substance Abuse
This Hyperkalaemia, Substance Abuse problem was reported by a physician from IN. A 26-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Tramadol Hydrochloride (dosage: NA). The following drugs were being taken at the same time:
  • Diclofenac
  • Pheniramine
  • Dexamethasone
  • Heparin
  • Steroid Antibacterials
When commencing Tramadol Hydrochloride, the patient experienced the following unwanted symptoms/side effects:
  • Hyperkalaemia
  • Substance Abuse
The patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as hyperkalaemia, may become evident only after a product is in use by the general population.

Vision Blurred, Cognitive Disorder
This is a report of a 49-year-old male patient (weight: NA) from GB. The patient developed the following symptoms/conditions: NA and was treated with Tramadol/tramadol Hydrochloride (dosage: 50 Mg, 3-4 Times A Day) starting NS. Concurrently used drugs:
  • Cyclizine
Soon after that, the consumer experienced the following side effects:
  • Vision Blurred
  • Cognitive Disorder
This opens a possibility that Tramadol/tramadol Hydrochloride treatment could cause the above reactions, including vision blurred, and some male subjects may be more susceptible.


Grand Mal Convulsion, Fall, Face Injury
A 29-year-old male patient (weight: NA) from US with the following symptoms/conditions: pain,depression,post-traumatic stress disorder started Tramadol treatment (dosage: 1-2 Tab Qid Po) on Dec 06, 2012. Soon after starting Tramadol treatment, the subject experienced various side effects, including:
  • Grand Mal Convulsion
  • Fall
  • Face Injury
Concurrently used drugs:
  • Mirtazapine
  • Mirtazapine
The patient was hospitalized. This finding indicates that some male patients could be more vulnerable to Tramadol.

Respiratory Arrest, Dependence, Poisoning
A 37-year-old female patient from PL (weight: NA) experienced symptoms, such as: NA and was treated with Tramadol Hydrochloride(dosage: NA). The treatment was initiated on NS. After that a consumer reported the following side effect(s):
  • Respiratory Arrest
  • Dependence
  • Poisoning
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Tramadol Hydrochloride efficacy: NA.The patient was hospitalized.

Gastritis
In this report, Tramadol Hydrochloride was administered for the following condition: back pain.A 32-year-old female consumer from IT (weight: NA) started Tramadol Hydrochloride treatment (dosage: NA) on Dec 19, 2013.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Gastritis
A possible interaction with other drugs could have contributed to this reaction:
  • Voltaren
  • Proton Pump Inhibitors
Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Tramadol Hydrochloride treatment could be related to the listed above side effect(s).

Urinary Tract Infection
This is a report of the following Tramadol side effect(s):
  • Urinary Tract Infection
A 61-year-old male patient from PR (weight: NA) presented with the following condition: pain,vitamin supplementation,rheumatoid arthritis and received a treatment with Tramadol (dosage: NA) starting: Jun 13, 2013.The following concurrently used drugs could have generated interactions:
  • Vitamin D
  • Humira
  • Humira
  • Lyrica
  • Zantac
  • Prednisone
  • Tekturna
  • Lisinopril
This report suggests that a Tramadol treatment could be associated with the listed above side effect(s).

Overdose, Multi-organ Failure, Dyspnoea
This Tramadol report was submitted by a 22-year-old male consumer from GB (weight: NA). The patient was diagnosed with: NA and Tramadol was administered (dosage: Take Up To 20 Tablets) starting: NS. The consumer developed a set of symptoms:
  • Overdose
  • Multi-organ Failure
  • Dyspnoea
Other drugs used simultaneously:
  • Benzodiazepines Nos
  • Cannabis
The patient was hospitalized.Those unexpected symptoms could be linked to a Tramadol treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Multi-organ Failure, Intentional Overdose, Circulatory Collapse, Dyspnoea, Malaise
This is a report of a possible correlation between Tramadol Hydrochloride use and the following symptoms/side effect(s):
  • Multi-organ Failure
  • Intentional Overdose
  • Circulatory Collapse
  • Dyspnoea
  • Malaise
which could contribute to an assessment of Tramadol Hydrochloride risk profile.A 22-year-old male consumer from GB (weight: NA) was suffering from NA and was treated with Tramadol Hydrochloride (dosage: NA) starting NS.Other concurrent medications:
  • Cannabis
  • Benzodiazepine Derivatives
The patient was hospitalized.

Multi-organ Failure, Overdose, Circulatory Collapse, Dyspnoea
A 22-year-old male patient from GB (weight: NA) presented with the following symptoms: NA and after a treatment with Tramadol Hydrochloride (dosage: 20 Df, Once/single) experienced the following side effect(s):
  • Multi-organ Failure
  • Overdose
  • Circulatory Collapse
  • Dyspnoea
The treatment was started on NS. Tramadol Hydrochloride was used in combination with the following drugs:
  • Benzodiazepines
  • Cannabis
The patient was hospitalized.This report could alert potential Tramadol Hydrochloride consumers.

Overdose, Multi-organ Failure, Circulatory Collapse, Dyspnoea
In this report, a 22-year-old male patient from GB (weight: NA) was affected by a possible Tramadol side effect.The patient was diagnosed with NA. After a treatment with Tramadol (dosage: 20 Tablet, Single, start date: NS), the patient experienced the following side effect(s):
  • Overdose
  • Multi-organ Failure
  • Circulatory Collapse
  • Dyspnoea
The following simultaneously used drugs could have led to this reaction:
  • Benzodiazepines Nos
  • Cannabis
The patient was hospitalized.The findings here stress that side effects should be taken into consideration when evaluating a Tramadol treatment.

Loss Of Consciousness, Overdose, Musculoskeletal Pain, Grand Mal Convulsion, Joint Dislocation
This is a report of a 21-year-old male patient from IR (weight: NA), who used Tramadol Hydrochloride (dosage: NA) for a treatment of NA. After starting a treatment on NS, the patient experienced the following side effect(s):
  • Loss Of Consciousness
  • Overdose
  • Musculoskeletal Pain
  • Grand Mal Convulsion
  • Joint Dislocation
The following drugs could possibly have interacted with the Tramadol Hydrochloride treatment
  • Methadone
Taken together, these observations suggest that a Tramadol Hydrochloride treatment could be related to side effect(s), such as Loss Of Consciousness, Overdose, Musculoskeletal Pain, Grand Mal Convulsion, Joint Dislocation.

Eating Disorder, Hallucination, Anxiety
This eating disorder side effect was reported by a health professional from CZ. A 35-year-old female patient (weight:NA) experienced the following symptoms/conditions: toothache,headache,back pain. The patient was prescribed Tramadol (dosage: 1500- 2250 Mg, Unk), which was started on NS. Concurrently used drugs: NA. When starting to take Tramadol the consumer reported the following symptoms:
  • Eating Disorder
  • Hallucination
  • Anxiety
These side effects may potentially be related to Tramadol.

Renal Failure Acute, Hepatocellular Injury
This is a Tramadol Hydrochloride/paracetamol side effect report of a 86-year-old female patient (weight:NA) from FR, suffering from the following symptoms/conditions: NA, who was treated with Tramadol Hydrochloride/paracetamol (dosage:As Needed, start time: NS), combined with:
  • Candesartan Cilexetil
  • Dabigatran Etexilate
  • Flecainide
  • Lercanidipine
  • Propranolol
, and developed a serious reaction and a renal failure acute side effect. The patient presented with:
  • Renal Failure Acute
  • Hepatocellular Injury
which developed after the beginning of treatment. The patient was hospitalized. This side effect report can indicate a possible existence of increased vulnerability to Tramadol Hydrochloride/paracetamol treatment in female patients suffering from NA, resulting in renal failure acute.

Dyspnoea, Hallucination, Feeling Abnormal, Anxiety
This report suggests a potential Tramadol Hydrochloride dyspnoea side effect(s) that can have serious consequences. A 64-year-old male patient from GB (weight:NA) was diagnosed with the following health condition(s): back pain and used Tramadol Hydrochloride (dosage: NA) starting Jan 04, 2014. Soon after starting Tramadol Hydrochloride the patient began experiencing various side effects, including:
  • Dyspnoea
  • Hallucination
  • Feeling Abnormal
  • Anxiety
Drugs used concurrently:
  • Furosemide
  • Amlodipine
  • Warfarin
Although Tramadol Hydrochloride demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as dyspnoea, may still occur.

Joint Dislocation, Grand Mal Convulsion, Toxicity To Various Agents
This joint dislocation problem was reported by a physician from IR. A 21-year-old male patient (weight: NA) was diagnosed with the following medical condition(s): NA.On NS a consumer started treatment with Tramadol (dosage: NA). The following drugs/medications were being taken at the same time:
  • Methadone
When commencing Tramadol, the patient experienced the following unwanted symptoms /side effects:
  • Joint Dislocation
  • Grand Mal Convulsion
  • Toxicity To Various Agents
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as joint dislocation, may become evident only after a product is in use by the general population.

Hyperhidrosis, Eating Disorder, Agitation, Anxiety
This is a Tramadol side effect report of a 27-year-old female patient (weight: NA) from CZ. The patient developed the following symptoms/conditions: NA and was treated with Tramadol (dosage: 150 Mg, Unk) starting NS. Concurrently used drugs: NA. Soon after that, the consumer experienced the following of symptoms:
  • Hyperhidrosis
  • Eating Disorder
  • Agitation
  • Anxiety
This opens a possibility that Tramadol could cause hyperhidrosis and that some female patients may be more susceptible.

Eating Disorder, Bulimia Nervosa, Weight Increased, Vomiting, Back Pain
A 32-year-old female patient (weight: NA) from CZ with the following symptoms: back pain started Tramadol treatment (dosage: 150 Mg, Bid) on NS. Soon after starting Tramadol treatment, the consumer experienced several side effects, including:
  • Eating Disorder
  • Bulimia Nervosa
  • Weight Increased
  • Vomiting
  • Back Pain
. Concurrently used drugs:
  • Escitalopram (20 Mg, Unk)
  • Trazodone (150 Mg, Unk)
  • Quetiapine (600 Mg, Unk)
  • Euthyrox
This finding indicates that some patients can be more vulnerable to developing Tramadol side effects, such as eating disorder.

Hallucination, Auditory, Abnormal Sleep-related Event
This hallucination, auditory side effect was reported by a consumer or non-health professional from US. A 80-year-old female patient (weight:NA) experienced the following symptoms/conditions: procedural pain.The patient was prescribed Tramadol (dosage: 1as Needed), which was started on Jan 29, 2014. Concurrently used drugs: NA..When starting to take Tramadol the consumer reported symptoms, such as:
  • Hallucination, Auditory
  • Abnormal Sleep-related Event
These side effects may potentially be related to Tramadol.

Disorientation, Angioedema, Ileus, Atelectasis, Confusional State, Respiratory Depression, Sedation
This is a report of a 69-year-old male patient (weight: NA) from US, suffering from the following symptoms/conditions: pain,hypertension, who was treated with Tramadol (dosage: NA, start time: Jan 29, 2014), combined with:
  • Carvedilol
and developed a serious reaction and side effect(s). The consumer presented with:
  • Disorientation
  • Angioedema
  • Ileus
  • Atelectasis
  • Confusional State
  • Respiratory Depression
  • Sedation
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Tramadol treatment in male patients, resulting in disorientation side effect. The patient was hospitalized.

Feeling Abnormal, Hallucination, Dyspnoea
This report suggests a potential Tramadol Feeling Abnormal, Hallucination, Dyspnoea side effect(s) that can have serious consequences. A 64-year-old male patient (weight: NA) from GB was diagnosed with the following symptoms/conditions: back pain and used Tramadol (dosage: 1 Df, Single Dose) starting Jan 04, 2014. Soon after starting Tramadol the patient began experiencing various side effects, including:
  • Feeling Abnormal
  • Hallucination
  • Dyspnoea
Drugs used concurrently:
  • Warfarin
  • Furosemide
  • Amlodipine
Although Tramadol demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as feeling abnormal, may still occur.

Hypomania, Abdominal Discomfort, Dizziness, Paraesthesia, Euphoric Mood
This Hypomania, Abdominal Discomfort, Dizziness, Paraesthesia, Euphoric Mood problem was reported by a physician from GB. A 62-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On Jan 10, 2014 this consumer started treatment with Tramadol (dosage: NA). The following drugs were being taken at the same time:
  • Allopurinol
  • Co-codamol
  • Folic Acid
  • Thiamine
  • Viazem Xl
  • Vitamin B Substances
  • Gabapentin
When commencing Tramadol, the patient experienced the following unwanted symptoms/side effects:
  • Hypomania
  • Abdominal Discomfort
  • Dizziness
  • Paraesthesia
  • Euphoric Mood
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as hypomania, may become evident only after a product is in use by the general population.

Grand Mal Convulsion, Cardiac Arrest, Stupor, Bedridden, Weight Increased, Balance Disorder
This is a report of a female patient (weight: NA) from US. The patient developed the following symptoms/conditions: pain and was treated with Tramadol (dosage: NA) starting 201209. Concurrently used drugs: NA.Soon after that, the consumer experienced the following side effects:
  • Grand Mal Convulsion
  • Cardiac Arrest
  • Stupor
  • Bedridden
  • Weight Increased
  • Balance Disorder
The patient was hospitalized and became disabled. This opens a possibility that Tramadol treatment could cause the above reactions, including grand mal convulsion, and some female subjects may be more susceptible.

Hypopnoea, Hallucination, Heart Rate Increased, Rash, Throat Tightness, Swollen Tongue, Muscle Twitching, Constipation, Dry Skin
A 55-year-old female patient (weight: NA) from US with the following symptoms/conditions: back pain started Tramadol Hcl treatment (dosage: NA) on Jan 23, 2014. Soon after starting Tramadol Hcl treatment, the subject experienced various side effects, including:
  • Hypopnoea
  • Hallucination
  • Heart Rate Increased
  • Rash
  • Throat Tightness
  • Swollen Tongue
  • Muscle Twitching
  • Constipation
  • Dry Skin
Concurrently used drugs:
  • Cyclobanzaprine
  • Aspirin
  • Tumeric
  • N.a.c.
  • Cranberry
  • Magnesium
  • Bromelain
  • Zyflamend
This finding indicates that some female patients could be more vulnerable to Tramadol Hcl.

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Top 10 Tramadol Side Effects for Women

Women Side EffectsReports
Completed Suicide 270
Nausea 216
Toxicity To Various Agents 204
Vomiting 179
Convulsion 168
Dizziness 161
Death 140
Confusional State 138
Somnolence 116
Pain 109

Top 10 Tramadol Side Effects for Men

Men Side EffectsReports
Completed Suicide 193
Toxicity To Various Agents 178
Convulsion 154
Overdose 143
Death 142
Vomiting 106
Confusional State 103
Dizziness 103
Nausea 103
Somnolence 83

Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


    Discuss Tramadol Side Effects

    Did You Have a Tramadol Side Effect?

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    Yes, Moderate
    Yes, Minor
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    How Effective is Tramadol for You?

    Exceeded Expectations
    Effective
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    Tramadol Safety Alerts, Active Ingredients, Usage Information

    NDC0093-0058
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameTramadol Hydrochloride
    NameTramadol Hydrochloride
    Dosage FormTABLET, FILM COATED
    RouteORAL
    On market since20020620
    LabelerTeva Pharmaceuticals USA Inc
    Active Ingredient(s)TRAMADOL HYDROCHLORIDE
    Strength(s)50
    Unit(s)mg/1
    Pharma ClassFull Opioid Agonists [MoA],Opioid Agonist [EPC]

    More About Tramadol

    Side Effects reported to FDA: 5054

    Tramadol safety alerts: 2010

    Reported deaths: 620

    Reported hospitalizations: 1109

    Ultram (tramadol hydrochloride), Ultracet (tramadol hydrochloride/acetaminophen): Label Change

    Audience: Pain management healthcare professionals

    [Posted 05/25/2010] Ortho-McNeil-Janssen and FDA notified healthcare professionals of changes to the Warnings section of the prescribing information for tramadol, a centrally acting synthetic opioid analgesic indicated for the management of moderate to moderately severe chronic pain. The strengthened Warnings information emphasizes the risk of suicide for patients who are addiction-prone, taking tranquilizers or antidepressant drugs and also warns of the risk of overdosage. Tramadol-related deaths have occurred in patients with previous histories of emotional disturbances or suicidal ideation or attempts, as well as histories of misuse of tranquilizers, alcohol, and other CNS-active drugs. Tramadol may be expected to have additive effects when used in conjunction with alcohol, other opioids or illicit drugs that cause central nervous system depression. Serious potential consequences of overdosage with tramadol are central nervous system depression, respiratory depression and death. Tramadol has mu-opioid agonist activity, can be abused and may be subject to criminal diversion.

    [April 2010 - Dear Healthcare Professional Letter: Ultram - Ortho-McNeil-Janssen]
    [April 2010 - Dear Healthcare Professional Letter: Ultracet - Ortho-McNeil-Janssen]

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