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Trifluridine Side Effects

Common Trifluridine Side Effects


The most commonly reported Trifluridine side effects (click to view or check a box to report):

Eye Pain (6)
Vision Blurred (4)
Dizziness (2)
Eye Irritation (2)
Eye Discharge (2)
Eye Swelling (2)
Eyelid Oedema (2)
Ocular Hyperaemia (2)
Scar (1)
Photophobia (1)
Sinus Disorder (1)
Stevens-johnson Syndrome (1)
Pain (1)
Fatigue (1)
Heart Rate Increased (1)
Fear (1)
Insomnia (1)
Keratopathy (1)
Neuropathy Peripheral (1)
Oedema Mouth (1)

➢ More



If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Trifluridine Side Effects Reported to FDA

The following Trifluridine reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Trifluridine on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Vision Blurred, Eye Pain
This is a report of a 83-year-old female patient (weight: NA) from UNITED STATES, suffering from the following symptoms/conditions: NA, who was treated with Trifluridine (dosage: NA, start time: NS), combined with:
  • Pataday
  • Muro 128
and developed a serious reaction and side effect(s). The consumer presented with:
  • Vision Blurred
  • Eye Pain
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Trifluridine treatment in female patients, resulting in vision blurred side effect.

Eye Pain, Stevens-johnson Syndrome, Vision Blurred
This report suggests a potential Trifluridine Eye Pain, Stevens-johnson Syndrome, Vision Blurred side effect(s) that can have serious consequences. A 83-year-old female patient (weight: NA) from UNITED STATES was diagnosed with the following symptoms/conditions: NA and used Trifluridine (dosage: Ophthalmic) starting NS. Soon after starting Trifluridine the patient began experiencing various side effects, including:
  • Eye Pain
  • Stevens-johnson Syndrome
  • Vision Blurred
Drugs used concurrently:
  • Muro 128
  • Pataday
Although Trifluridine demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as eye pain, may still occur.

Vision Blurred, Corneal Oedema, Keratopathy, Pain, Photophobia, Neuropathy Peripheral
This Vision Blurred, Corneal Oedema, Keratopathy, Pain, Photophobia, Neuropathy Peripheral problem was reported by a health professional from UNITED STATES. A 54-year-old female patient (weight: NA) was diagnosed with the following symptoms/conditions: herpes ophthalmic. On Jun 01, 2011 this consumer started treatment with Trifluridine (dosage: 1 Drop Every 2 Hrs. Less Than Or Equal To 9/day 046). The following drugs were being taken at the same time: NA. When commencing Trifluridine, the patient experienced the following unwanted symptoms/side effects:
  • Vision Blurred
  • Corneal Oedema
  • Keratopathy
  • Pain
  • Photophobia
  • Neuropathy Peripheral
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as vision blurred, may become evident only after a product is in use by the general population.

Erythema Of Eyelid, Eyelid Oedema, Eye Irritation, Fatigue, Vision Blurred, Eye Disorder, Fear, Dizziness, Eye Pain
This is a report of a 57-year-old male patient (weight: NA) from UNITED STATES. The patient developed the following symptoms/conditions: eye infection and was treated with Trifluridine (dosage: 1 Drop) starting Jun 20, 2011. Concurrently used drugs: NA.Soon after that, the consumer experienced the following side effects:
  • Erythema Of Eyelid
  • Eyelid Oedema
  • Eye Irritation
  • Fatigue
  • Vision Blurred
  • Eye Disorder
  • Fear
  • Dizziness
  • Eye Pain
This opens a possibility that Trifluridine treatment could cause the above reactions, including erythema of eyelid, and some male subjects may be more susceptible.


Eye Pain, Eye Swelling, Eye Irritation, Visual Acuity Reduced
A 70-year-old male patient (weight: NA) from UNITED STATES with the following symptoms/conditions: eye pain,photophobia started Trifluridine treatment (dosage: 1 Gtt Q2h Od Ophthalmic) on Mar 24, 2011. Soon after starting Trifluridine treatment, the subject experienced various side effects, including:
  • Eye Pain
  • Eye Swelling
  • Eye Irritation
  • Visual Acuity Reduced
Concurrently used drugs: NA. This finding indicates that some male patients could be more vulnerable to Trifluridine.

Auricular Swelling, Condition Aggravated, Eye Discharge, Eye Pain, Heart Rate Increased, Ocular Hyperaemia, Oedema Mouth, Scar, Sinus Disorder
A 53-year-old female patient from UNITED STATES (weight: NA) experienced symptoms, such as: keratitis herpetic and was treated with Trifluridine 1 % Ophthalmic Solution(dosage: (ophthalmic)). The treatment was initiated on Aug 02, 2010. After that a consumer reported the following side effect(s):
  • Auricular Swelling
  • Condition Aggravated
  • Eye Discharge
  • Eye Pain
  • Heart Rate Increased
  • Ocular Hyperaemia
  • Oedema Mouth
  • Scar
  • Sinus Disorder
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Trifluridine 1 % Ophthalmic Solution efficacy: NA.

Abdominal Discomfort, Abdominal Pain Upper, Abnormal Sensation In Eye, Application Site Pain, Asthenia, Diarrhoea, Dizziness, Eyelid Oedema, Insomnia
In this report, Trifluridine was administered for the following condition: herpes simplex.A 68-year-old female consumer from UNITED STATES (weight: NA) started Trifluridine treatment (dosage: 1 Drop Every 2 Hours While Wake Eye) on Mar 15, 2010.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Abdominal Discomfort
  • Abdominal Pain Upper
  • Abnormal Sensation In Eye
  • Application Site Pain
  • Asthenia
  • Diarrhoea
  • Dizziness
  • Eyelid Oedema
  • Insomnia
A possible interaction with other drugs could have contributed to this reaction: NA.Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Trifluridine treatment could be related to the listed above side effect(s).

Eye Discharge, Eye Pain, Eye Pruritus, Eye Swelling, Ocular Hyperaemia
This is a report of the following Trifluridine side effect(s):
  • Eye Discharge
  • Eye Pain
  • Eye Pruritus
  • Eye Swelling
  • Ocular Hyperaemia
A 53-year-old female patient from UNITED STATES (weight: NA) presented with the following condition: herpes ophthalmic and received a treatment with Trifluridine (dosage: One Drop Every 2 Hours Up To 9 Every 2 Hours) starting: Jun 17, 2010.The following concurrently used drugs could have generated interactions: NA.This report suggests that a Trifluridine treatment could be associated with the listed above side effect(s).



Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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    Trifluridine Safety Alerts, Active Ingredients, Usage Information

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    Side Effects reported to FDA: 8

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