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Vitamin K Side Effects

Common Vitamin K Side Effects


The most commonly reported Vitamin K side effects are:
Blistering Under The Skin (1)

If you have experienced a side effect listed above, you can check a box to report it.


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If you or someone in your family has experienced a serious side effect to a health product, you are encouraged to report the experience to your health care professional (e.g. physician, pharmacist). You could also complete a copy of the side effect reporting form or report your side effect to FDA.

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

Vitamin K Side Effects Reported to FDA

The following Vitamin K reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS).
FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.


The appearance of Vitamin K on this list does not mean that FDA has concluded that the drug has the listed risk. It means that FDA has identified a potential safety issue, but it does not mean that FDA has found a causal relationship between the drug and the listed risk.
Pulseless Electrical Activity, Respiratory Arrest, Shock Haemorrhagic, Hypotension
This is a report of a 48-year-old male patient (weight: NA) from US, suffering from the following symptoms/conditions: international normalised ratio increased, who was treated with Vitamin K (dosage: NA, start time: NS), combined with: NA. and developed a serious reaction and side effect(s). The consumer presented with:
  • Pulseless Electrical Activity
  • Respiratory Arrest
  • Shock Haemorrhagic
  • Hypotension
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Vitamin K treatment in male patients, resulting in pulseless electrical activity side effect. The patient was hospitalized and became disabled.

Cardiac Arrest
This report suggests a potential Vitamin K Cardiac Arrest side effect(s) that can have serious consequences. A 65-year-old male patient (weight: NA) from US was diagnosed with the following symptoms/conditions: NA and used Vitamin K (dosage: NA) starting Jan 19, 2014. Soon after starting Vitamin K the patient began experiencing various side effects, including:
  • Cardiac Arrest
Drugs used concurrently:
  • Carvedilol
  • D51/2 Normal Saline
  • Diovan
  • Epinephrine Drip
  • Morphine
  • Potassium Chloride
  • Pantoprazole
  • Spironolactone
The patient was hospitalized. Although Vitamin K demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as cardiac arrest, may still occur.

Cardio-respiratory Arrest, Infusion Related Reaction
This Cardio-respiratory Arrest, Infusion Related Reaction problem was reported by a pharmacist from US. A 56-year-old male patient (weight: NA) was diagnosed with the following symptoms/conditions: international normalised ratio increased. On May 15, 2013 this consumer started treatment with Vitamin K (dosage: NA). The following drugs were being taken at the same time: NA. When commencing Vitamin K, the patient experienced the following unwanted symptoms/side effects:
  • Cardio-respiratory Arrest
  • Infusion Related Reaction
Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as cardio-respiratory arrest, may become evident only after a product is in use by the general population.

Chills, Pyrexia, Vomiting, Cough, Decreased Appetite, Malaise, Agitation, Insomnia
This is a report of a 67-year-old male patient (weight: NA) from US. The patient developed the following symptoms/conditions: blood disorder and was treated with Vitamin K (dosage: Don^t Know Was Given In Hospit) starting Aug 21, 2012. Concurrently used drugs: NA.Soon after that, the consumer experienced the following side effects:
  • Chills
  • Pyrexia
  • Vomiting
  • Cough
  • Decreased Appetite
  • Malaise
  • Agitation
  • Insomnia
This opens a possibility that Vitamin K treatment could cause the above reactions, including chills, and some male subjects may be more susceptible.


Hypotension, Dizziness, Asthenia
A 62-year-old male patient (weight: NA) from GR with the following symptoms/conditions: coronary artery disease started Vitamin K2 treatment (dosage: 100 Micrograms Daily) on NS. Soon after starting Vitamin K2 treatment, the subject experienced various side effects, including:
  • Hypotension
  • Dizziness
  • Asthenia
Concurrently used drugs:
  • Alfuzosin (10mg Daily)
  • Rosuvastatin (10mg Daily)
  • Aspirin (100mg Daily)
  • Atenolol (25mg Daily)
This finding indicates that some male patients could be more vulnerable to Vitamin K2.

Duodenal Ulcer, Neutropenia, Hepatic Failure, Pneumonia, Gastrointestinal Ulcer, Febrile Neutropenia
A 68-year-old female patient from PHILIPPINES (weight: NA) experienced symptoms, such as: NA and was treated with Vitamin K Tab(dosage: NA). The treatment was initiated on Oct 26, 2010. After that a consumer reported the following side effect(s):
  • Duodenal Ulcer
  • Neutropenia
  • Hepatic Failure
  • Pneumonia
  • Gastrointestinal Ulcer
  • Febrile Neutropenia
Concurrently used drugs, which potentially could have contributed to side effect(s) or affected Vitamin K Tab efficacy:
  • Tinzaparin (Dose:10000 Unit(s))
  • Docetaxel (Form: Vial)
  • Docetaxel (Form: Vial)
  • Omeprazole
  • Fluconazole
  • Mucosta
  • Trastuzumab
  • Ciprofloxacin Hydrochloride
The patient was hospitalized and became disabled.

Gastrointestinal Ulcer, Neutropenia, Hepatic Failure, Duodenal Ulcer, Febrile Neutropenia, Cardio-respiratory Arrest, Pneumonia
In this report, Vitamin K Tab was administered for the following condition: NA.A female consumer from PHILIPPINES (weight: NA) started Vitamin K Tab treatment (dosage: NA) on Oct 26, 2010.Sometime after starting the treatment, the patient complained of the following side effect(s):
  • Gastrointestinal Ulcer
  • Neutropenia
  • Hepatic Failure
  • Duodenal Ulcer
  • Febrile Neutropenia
  • Cardio-respiratory Arrest
  • Pneumonia
A possible interaction with other drugs could have contributed to this reaction:
  • Mucosta
  • Herceptin (Last Dose Prior To Sae : 26 Oct 2010, Permanently Discontinued On 16 Nov 2010)
  • Fluconazole
  • Tinzaparin (Tdd 10000 Units)
  • Docetaxel (Last Dose Prior To Sae 26 Oct 2010, Permanently Discontinued On 16 Nov 2010)
  • Omeprazole
  • Ciprofloxacin
The patient was hospitalized and became disabled.Establishing a causal relationship between a specific drug and consumer's side effects is complex, but it is possible that in this report Vitamin K Tab treatment could be related to the listed above side effect(s).

Pneumonia, Febrile Neutropenia, Duodenal Ulcer, Hepatic Failure, Gastrointestinal Ulcer
This is a report of the following Vitamin K Tab side effect(s):
  • Pneumonia
  • Febrile Neutropenia
  • Duodenal Ulcer
  • Hepatic Failure
  • Gastrointestinal Ulcer
A female patient from PHILIPPINES (weight: NA) presented with the following condition: NA and received a treatment with Vitamin K Tab (dosage: NA) starting: Nov 05, 2010.The following concurrently used drugs could have generated interactions:
  • Fluconazole
  • Ciprofloxacin
  • Herceptin (Last Dose Prior To Sae : 26 Oct 2010, Permanently Discontinued On 16 Nov 2010)
  • Docetaxel (Last Dose Prior To Sae 26 Oct 2010, Permanently Discontinued On 16 Nov 2010)
  • Mucosta
  • Omeprazole
  • Tinzaparin (Tdd 10000 Units)
The patient was hospitalized and became disabled.This report suggests that a Vitamin K Tab treatment could be associated with the listed above side effect(s).

Pulmonary Haemorrhage
This Vitamin K Tab report was submitted by a 6-year-old male consumer from MEXICO (weight: NA). The patient was diagnosed with: gastrointestinal haemorrhage,bronchopulmonary aspergillosis,sepsis,candidiasis,gastritis and Vitamin K Tab was administered (dosage: 0.3 Mg/kg, 1x/day) starting: Feb 13, 2012. The consumer developed a set of symptoms:
  • Pulmonary Haemorrhage
Other drugs used simultaneously:
  • Vfend (12 Mg/kg, 2x/day)
  • Ciprofloxacin (20 Mg/kg, 2x/day)
  • Amphotericin B (Unk)
  • Omeprazole (1 Mg, 2x/day)
  • Sulfamethoxazole + Trimethoprim (20 Mg/kg, 3x/day)
  • Meropenem (100 Mg/kg, 3x/day)
  • Vancomycin (40 Mg/kg, 4x/day)
Those unexpected symptoms could be linked to a Vitamin K Tab treatment, however establishing a potential drug-safety problem requires a more detailed clinical analysis.

Duodenal Ulcer, Pneumonia, Hepatic Failure, Gastrointestinal Ulcer, Febrile Neutropenia
This is a report of a possible correlation between Vitamin K Tab use and the following symptoms/side effect(s):
  • Duodenal Ulcer
  • Pneumonia
  • Hepatic Failure
  • Gastrointestinal Ulcer
  • Febrile Neutropenia
which could contribute to an assessment of Vitamin K Tab risk profile.A 68-year-old female consumer from PHILIPPINES (weight: NA) was suffering from NA and was treated with Vitamin K Tab (dosage: NA) starting Nov 05, 2010.Other concurrent medications:
  • Omeprazole
  • Ciprofloxacin
  • Fluconazole
  • Docetaxel (Form: Vial)
  • Mucosta
  • Docetaxel (Form: Vial)
  • Trastuzumab
  • Tinzaparin (Dose:10000 Unit(s))
The patient was hospitalized and became disabled.

Oedema Peripheral, Deep Vein Thrombosis, Pulmonary Embolism, Dyspnoea, Fatigue
A 40-year-old female patient from UNITED STATES (weight: NA) presented with the following symptoms: NA and after a treatment with Vitamin K Tab (dosage: NA) experienced the following side effect(s):
  • Oedema Peripheral
  • Deep Vein Thrombosis
  • Pulmonary Embolism
  • Dyspnoea
  • Fatigue
The treatment was started on Jan 01, 2008. Vitamin K Tab was used in combination with the following drugs:
  • Yasmin
  • Yaz
The patient was hospitalized.This report could alert potential Vitamin K Tab consumers.

Coma Hepatic, Vomiting, Metastases To Bone, Thrombocytopenia, Pleural Effusion, Nausea, Metastases To Liver, Fatigue
In this report, a 45-year-old female patient from JAPAN (weight: NA) was affected by a possible Vitamin K Tab side effect.The patient was diagnosed with NA. After a treatment with Vitamin K Tab (dosage: NA, start date: NS), the patient experienced the following side effect(s):
  • Coma Hepatic
  • Vomiting
  • Metastases To Bone
  • Thrombocytopenia
  • Pleural Effusion
  • Nausea
  • Metastases To Liver
  • Fatigue
The following simultaneously used drugs could have led to this reaction:
  • Promethazine
  • Levofloxacin
  • Metylprednisolon Solubile
  • Carboplatin (450 Mg, Other)
  • Arimidex
  • Esomeprazole
  • Oxycodone Hcl
  • Gemcitabine Hydrochloride (1300 Mg, Other)
The findings here stress that side effects should be taken into consideration when evaluating a Vitamin K Tab treatment.

Cutaneous Lupus Erythematosus
This is a report of a 65-year-old female patient from UNITED STATES (weight: NA), who used Vitamin K2 (dosage: Unk) for a treatment of NA. After starting a treatment on Nov 12, 2010, the patient experienced the following side effect(s):
  • Cutaneous Lupus Erythematosus
The following drugs could possibly have interacted with the Vitamin K2 treatment
  • Simvastatin (Unk)
  • Prolia
  • Garlic (Unk)
  • Vitamin B1 Tab (Unk)
  • Calcium (Unk)
  • Lutein (Unk)
  • Centrum (Unk)
  • Lisinopril (Unk)
Taken together, these observations suggest that a Vitamin K2 treatment could be related to side effect(s), such as Cutaneous Lupus Erythematosus.

Condition Aggravated, Pneumonia, Pulmonary Oedema, Cardiac Failure
This condition aggravated side effect was reported by a health professional from UNITED STATES. A 86-year-old male patient (weight:NA) experienced the following symptoms/conditions: NA. The patient was prescribed Vitamin K Tab (dosage: NA), which was started on Nov 16, 2011. Concurrently used drugs:
  • Furosemide
  • Piperacillin
  • Vancomycin
  • Ipratropium Bromide
  • Insulin
  • Azithromycin
  • Lorazepam
  • Risperidone
When starting to take Vitamin K Tab the consumer reported the following symptoms:
  • Condition Aggravated
  • Pneumonia
  • Pulmonary Oedema
  • Cardiac Failure
These side effects may potentially be related to Vitamin K Tab.

Hypothyroidism, Renal Failure Acute
This is a Vitamin K Antagonist side effect report of a 80-year-old male patient (weight:NA) from JAPAN, suffering from the following symptoms/conditions: atrial fibrillation,hypertension, who was treated with Vitamin K Antagonist (dosage:NA, start time: NS), combined with:
  • Candesartan Cilexetil
  • Lasix
  • Tamsulosin Hcl
  • Metformin Hcl
  • Anti-tumor Necrosis Factor Monoclonal Antibody
  • Diamicron
  • Cordarone
, and developed a serious reaction and a hypothyroidism side effect. The patient presented with:
  • Hypothyroidism
  • Renal Failure Acute
which developed after the beginning of treatment. The patient was hospitalized. This side effect report can indicate a possible existence of increased vulnerability to Vitamin K Antagonist treatment in male patients suffering from atrial fibrillation,hypertension, resulting in hypothyroidism.

Hepatic Neoplasm Malignant, Haemorrhage, Succinylacetone Increased, Treatment Noncompliance, Amino Acid Level Increased
This report suggests a potential Vitamin K Tab hepatic neoplasm malignant side effect(s) that can have serious consequences. A 21-year-old male patient from FRANCE (weight:NA) was diagnosed with the following health condition(s): NA and used Vitamin K Tab (dosage: NA) starting May 06, 1997. Soon after starting Vitamin K Tab the patient began experiencing various side effects, including:
  • Hepatic Neoplasm Malignant
  • Haemorrhage
  • Succinylacetone Increased
  • Treatment Noncompliance
  • Amino Acid Level Increased
Drugs used concurrently:
  • Vitamin D
  • Orfadin (80 Mg (40 Mg, 2 In 1 D) Oral)
Although Vitamin K Tab demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as hepatic neoplasm malignant, may still occur.

Neutropenia, Pneumonia, Hepatitis Viral, Febrile Neutropenia, Gastrointestinal Ulcer, Duodenal Ulcer
This neutropenia problem was reported by a consumer or non-health professional from PHILIPPINES. A female patient (weight: NA) was diagnosed with the following medical condition(s): NA.On Nov 09, 2010 a consumer started treatment with Vitamin K Tab (dosage: NA). The following drugs/medications were being taken at the same time:
  • Docetaxel (Last Dose Prior To Sae 26 Oct 2010, Permanently Discontinued On 16 Nov 2010)
  • Fluconazole
  • Herceptin (Last Dose Prior To Sae : 26 Oct 2010, Permanently Discontinued On 16 Nov 2010)
  • Tinzaparin (Tdd 10000 Units)
  • Ciprofloxacin
  • Omeprazole
  • Mucosta
When commencing Vitamin K Tab, the patient experienced the following unwanted symptoms /side effects:
  • Neutropenia
  • Pneumonia
  • Hepatitis Viral
  • Febrile Neutropenia
  • Gastrointestinal Ulcer
  • Duodenal Ulcer
The patient was hospitalized and became disabled. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as neutropenia, may become evident only after a product is in use by the general population.

Tonic Convulsion, Appetite Disorder, Oliguria, Cyanosis Neonatal, Apnoea, Peripheral Vascular Disorder, Hypotension, Neonatal Hypotension, Infantile Apnoeic Attack
This is a Vitamin K Tab side effect report of a male patient (weight: NA) from TURKEY. The patient developed the following symptoms/conditions: NA and was treated with Vitamin K Tab (dosage: NA) starting NS. Concurrently used drugs:
  • Methergine (0.2 Mg, Unk)
Soon after that, the consumer experienced the following of symptoms:
  • Tonic Convulsion
  • Appetite Disorder
  • Oliguria
  • Cyanosis Neonatal
  • Apnoea
  • Peripheral Vascular Disorder
  • Hypotension
  • Neonatal Hypotension
  • Infantile Apnoeic Attack
The patient was hospitalized. This opens a possibility that Vitamin K Tab could cause tonic convulsion and that some male patients may be more susceptible.

Rash Pustular, Contusion, Injection Site Rash, Rash Erythematous
A 34-year-old female patient (weight: NA) from UNITED STATES with the following symptoms: international normalised ratio increased,blood thromboplastin increased started Vitamin K1 treatment (dosage: 1 Shot) on Nov 29, 2011. Soon after starting Vitamin K1 treatment, the consumer experienced several side effects, including:
  • Rash Pustular
  • Contusion
  • Injection Site Rash
  • Rash Erythematous
. Concurrently used drugs: NA. This finding indicates that some patients can be more vulnerable to developing Vitamin K1 side effects, such as rash pustular.

Deep Vein Thrombosis, Colitis, Hepatic Function Abnormal, Pain, Angina Pectoris, Gastrointestinal Disorder, Pulmonary Embolism, Gallbladder Disorder, Intestinal Obstruction
This deep vein thrombosis side effect was reported by a consumer or non-health professional from UNITED STATES. A 27-year-old female patient (weight:NA) experienced the following symptoms/conditions: NA.The patient was prescribed Vitamin K Tab (dosage: NA), which was started on Jan 01, 1999. Concurrently used drugs:
  • Zofran
  • Zoloft
  • Yasmin (Unk)
  • Xanax
  • Chantix
  • Yaz (Unk)
  • Percocet (Unk)
  • Percocet (Unk)
.When starting to take Vitamin K Tab the consumer reported symptoms, such as:
  • Deep Vein Thrombosis
  • Colitis
  • Hepatic Function Abnormal
  • Pain
  • Angina Pectoris
  • Gastrointestinal Disorder
  • Pulmonary Embolism
  • Gallbladder Disorder
  • Intestinal Obstruction
These side effects may potentially be related to Vitamin K Tab. The patient was hospitalized.

Eye Movement Disorder, Respiratory Arrest, Dyskinesia
This is a report of a 73-year-old female patient (weight: NA) from UNITED STATES, suffering from the following symptoms/conditions: haematuria,coagulopathy, who was treated with Vitamin K Tab (dosage: Vitamin K 10mg X1 Iv, start time: Oct 13, 2011), combined with: NA. and developed a serious reaction and side effect(s). The consumer presented with:
  • Eye Movement Disorder
  • Respiratory Arrest
  • Dyskinesia
which developed after the beginning of treatment. This case can indicate the possible existence of increased vulnerability to Vitamin K Tab treatment in female patients, resulting in eye movement disorder side effect.

Fall, Retching, Malaise, Pain, Feeling Abnormal, Femur Fracture
This report suggests a potential Vitamin K Tab Fall, Retching, Malaise, Pain, Feeling Abnormal, Femur Fracture side effect(s) that can have serious consequences. A 85-year-old female patient (weight: NA) from BRAZIL was diagnosed with the following symptoms/conditions: NA and used Vitamin K Tab (dosage: 6 Drp, Unk) starting NS. Soon after starting Vitamin K Tab the patient began experiencing various side effects, including:
  • Fall
  • Retching
  • Malaise
  • Pain
  • Feeling Abnormal
  • Femur Fracture
Drugs used concurrently:
  • Puran (1 Df, Unk)
  • Simvastatin (1 Df, Unk)
  • Exelon (4.5 Mg, 1 Capsule A Day)
Although Vitamin K Tab demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as fall, may still occur.

Appetite Disorder, Lethargy, Tonic Convulsion
This Appetite Disorder, Lethargy, Tonic Convulsion problem was reported by a health professional from TURKEY. A female patient (weight: NA) was diagnosed with the following symptoms/conditions: NA. On NS this consumer started treatment with Vitamin K Tab (dosage: NA). The following drugs were being taken at the same time:
  • Methergine (0.2 Mg, Unk)
When commencing Vitamin K Tab, the patient experienced the following unwanted symptoms/side effects:
  • Appetite Disorder
  • Lethargy
  • Tonic Convulsion
The patient was hospitalized.Although all drugs are carefully tested before they are licensed for use, they carry side effect risks. Some side effects, such as appetite disorder, may become evident only after a product is in use by the general population.

Lethargy, Appetite Disorder, Tonic Convulsion
This is a report of a female patient (weight: NA) from TURKEY. The patient developed the following symptoms/conditions: NA and was treated with Vitamin K Tab (dosage: NA) starting NS. Concurrently used drugs:
  • Methergine (0.2 Mg, Unk)
Soon after that, the consumer experienced the following side effects:
  • Lethargy
  • Appetite Disorder
  • Tonic Convulsion
The patient was hospitalized. This opens a possibility that Vitamin K Tab treatment could cause the above reactions, including lethargy, and some female subjects may be more susceptible.

Irritability, Clonic Convulsion
A female patient (weight: NA) from TURKEY with the following symptoms/conditions: NA started Vitamin K Tab treatment (dosage: NA) on NS. Soon after starting Vitamin K Tab treatment, the subject experienced various side effects, including:
  • Irritability
  • Clonic Convulsion
Concurrently used drugs:
  • Methergine (0.2 Mg, Unk)
The patient was hospitalized. This finding indicates that some female patients could be more vulnerable to Vitamin K Tab.

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Keep Track of Side Effects

Note Your Observations

It is really important to keep of your symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

  • You can use them to remind you of details that may alert your health care professional(s) to a problem
  • You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

  • Log Form

    You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

    Medicine Name and Dosage:
    Side Effects Scale Date & Time Other Medicine(s) or Treatment(s)
    Scale: 1 = very mild to 10 = very bad

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


    Discuss Vitamin K Side Effects

    Did You Have a Vitamin K Side Effect?

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    How Effective is Vitamin K for You?

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    Effective
    Somewhat Effective
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    Vitamin K Safety Alerts, Active Ingredients, Usage Information

    NDC0409-9157
    TypeHUMAN PRESCRIPTION DRUG
    Proprietary NameVitamin K1
    NamePHYTONADIONE
    Dosage FormINJECTION, EMULSION
    RouteINTRAMUSCULAR; INTRAVENOUS; SUBCUTANEOUS
    On market since19830725
    LabelerHospira, Inc.
    Active Ingredient(s)PHYTONADIONE
    Strength(s)2
    Unit(s)mg/mL
    Pharma ClassIncreased Prothrombin Activity [PE],Reversed Anticoagulation Activity [PE],Vitamin K [Chemical/Ingre

    More About Vitamin k

    Side Effects reported to FDA: 59

    Vitamin K safety alerts: No

    Reported deaths: 10

    Reported hospitalizations: 23

    Latest Vitamin K clinical trials