Zyprexa Safety Questions, Zyprexa Answers
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Zyprexa Safety Reports
Total Zyprexa reports: 3431.Zyprexa FDA safety alerts: 2002 2004 2005 .
Reported deaths: 377 Reported hospitalizations: 1911.
Take Zyprexa Side Effects Survey or Share Your Zyprexa Story.
Reported Zyprexa Side Effects: hypertension, metabolic disorder, weight increased, diabetes mellitus non-insulin-dependent, diabetes mellitus inadequate control, diabetes mellitus insulin-dependent, diabetes mellitus, diabetes mellitus management, hyperglycaemia, blood triglycerides increased, diabetic ketoacidosis.
Zyprexa Usage.
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Zyprexa Side Effects Report #5221601-7Physician from JAPAN reported ZYPREXA problem on Jan 18, 2007. Male patient, 69 years of age, was diagnosed with schizophrenia and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: deep vein thrombosis. ZYPREXA dosage: unknown. Patient recovered.
Zyprexa Side Effects Report #5221602-9
ZYPREXA problem was reported by a Physician from JAPAN on Jan 17, 2007. Male patient, 71 years of age, was diagnosed with schizophrenia and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: brain contusion, subcutaneous haematoma, urinary retention. ZYPREXA dosage: 20 MG, DAILY (1/D). During the same period patient was treated with SILECE, LENDORMIN, SENNOSIDE A, DEPAKENE. Patient was hospitalized. Patient recovered.
Zyprexa Side Effects Report #5221603-0
Consumer or non-health professional from CANADA reported ZYPREXA problem on Jan 19, 2007. Male patient, 35 years of age, was diagnosed with schizophrenia and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: abnormal behaviour, asthenia, blood pressure decreased, blood pressure increased, coma, diabetes mellitus, haemorrhage, hepatic function abnormal, loss of consciousness. ZYPREXA dosage: unknown. During the same period patient was treated with ZYPREXA ZYDIS. Patient was hospitalized. Patient died on 12/07/2006.
Zyprexa Side Effects Report #5221604-2
ZYPREXA problem was reported by a Physician from GERMANY on Jan 18, 2007. Male patient, 19 years of age, was diagnosed with schizophrenia and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: lymphocyte count. ZYPREXA dosage: 15 MG, UNK. During the same period patient was treated with SOLIAN, TAVOR. Patient recovered.
Zyprexa Side Effects Report #5221605-4
Consumer or non-health professional from UNITED STATES reported ZYPREXA problem on Jan 18, 2007. Female patient, 55 years of age, weighting 180.0 lb, was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: diabetes mellitus, myocardial infarction. ZYPREXA dosage: 2.5 MG, UNK. During the same period patient was treated with CARBAMAZEPINE. Patient was hospitalized. Patient recovered.
Zyprexa Side Effects Report #5221606-6
ZYPREXA problem was reported by a Consumer or non-health professional from UNITED STATES on Jan 18, 2007. Male patient, 53 years of age, weighting 152.0 lb, was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: blood cholesterol abnormal, diabetes mellitus, hepatitis viral, metabolic disorder, pancreatitis. ZYPREXA dosage: 10 MG, UNK. Patient recovered.
Zyprexa Side Effects Report #5221607-8
Consumer or non-health professional from UNITED STATES reported ZYPREXA problem on Jan 18, 2007. Female patient, 36 years of age, weighting 170.0 lb, was diagnosed with depression and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: cardiac disorder, diabetes mellitus. ZYPREXA dosage: unknown. Patient recovered.
Zyprexa Side Effects Report #5221608-X
ZYPREXA problem was reported by a Physician from JAPAN on Jan 19, 2007. Male patient, 65 years of age, was diagnosed with schizophrenia, insomnia, parkinsonism, depression, headache and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: interstitial lung disease, respiratory failure. ZYPREXA dosage: 5 MG, UNK. During the same period patient was treated with HALOPERIDOL, NITRAZEPAM, PROMETHAZINE, AMITRIPTYLINE, LEXOTAN, LOXOPROFEN. Patient was hospitalized. Patient recovered.
Zyprexa Side Effects Report #5221609-1
Physician from GERMANY reported ZYPREXA problem on Jan 19, 2007. Female patient, 25 years of age, was diagnosed with schizophrenia and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: leukopenia. ZYPREXA dosage: 2.5 MG, UNK. Patient recovered.
Zyprexa Side Effects Report #5221610-8
ZYPREXA problem was reported by a Physician from GERMANY on Jan 23, 2007. Female patient, 70 years of age, was diagnosed with schizophrenia, paranoid type and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: retinal vein occlusion. ZYPREXA dosage: unknown. During the same period patient was treated with DELIX, AKINETON. Patient recovered.
Zyprexa Side Effects Report #5221617-0
Physician from UNITED STATES reported ZYPREXA problem on Jan 19, 2007. Male patient, 26 years of age, was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: white blood cell count decreased. ZYPREXA dosage: unknown. Patient recovered.
Zyprexa Side Effects Report #5221618-2
ZYPREXA problem was reported by a Consumer or non-health professional from UNITED STATES on Jan 16, 2007. Female patient, 68 years of age, weighting 160.0 lb, was diagnosed with depression and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: cardiac failure, diabetes mellitus, diabetic coma, hyperglycaemia, leg amputation. ZYPREXA dosage: 10 MG, UNK. Patient was hospitalized and became disabled. Patient recovered.
Zyprexa Side Effects Report #5221761-8
Physician from AUSTRALIA reported ZYPREXA problem on Jan 17, 2007. Male patient, 35 years of age, was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: neutrophilia. ZYPREXA dosage: 10 MG, DAILY (1/D). Patient was hospitalized. Patient recovered.
Zyprexa Side Effects Report #5221762-X
ZYPREXA problem was reported by a Physician from UNITED KINGDOM on Jan 23, 2007. Male patient, 86 years of age, weighting 132.3 lb, was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: leukocytosis, neuroleptic malignant syndrome. ZYPREXA dosage: 5 MG, UNK. During the same period patient was treated with CLOPIXOL DEPOT, PRIADEL. Patient was hospitalized and became disabled. Patient died.
Zyprexa Side Effects Report #5221825-9
Physician from JAPAN reported ZYPREXA problem on Jan 24, 2007. Female patient, 35 years of age, was diagnosed with schizophrenia and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: prescribed overdose, white blood cell count decreased. ZYPREXA dosage: 35 MG, DAILY (1/D). During the same period patient was treated with HALOPERIDOL. Patient recovered.
Zyprexa Side Effects Report #5221826-0
ZYPREXA problem was reported by a Physician from HUNGARY on Jan 24, 2007. Male patient, 25 years of age, was diagnosed with schizophrenia, paranoid type and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: prescribed overdose. ZYPREXA dosage: 20 MG, 3/D. During the same period patient was treated with RISPERIDONE. Patient recovered.
Zyprexa Side Effects Report #5221827-2
Physician from SOUTH AFRICA reported ZYPREXA problem on Jan 25, 2007. Female patient, 44 years of age, was diagnosed with hallucination, infection, cardiac disorder, diabetes mellitus, hypothyroidism, anxiety and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: agitation, hepatic failure, renal failure. ZYPREXA dosage: 10 MG, DAILY (1/D). During the same period patient was treated with DIGOXIN, ISOPTIN, GLUCOPHAGE, GLICLAZIDE, ELTROXIN, ALZAM, CLONAZEPAM. Patient died on 12/10/2006.
Zyprexa Side Effects Report #5221831-4
ZYPREXA problem was reported by a Consumer or non-health professional from UNITED STATES on Jan 18, 2007. Female patient, 45 years of age, weighting 280.0 lb, was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: diabetes mellitus, pulmonary thrombosis. ZYPREXA dosage: 10 MG, 2/D. Patient was hospitalized. Patient recovered.
Zyprexa Side Effects Report #5221833-8
Physician from JAPAN reported ZYPREXA problem on Jan 25, 2007. Male patient, 52 years of age, weighting 154.3 lb, was diagnosed with schizophrenia, prophylaxis and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: cardio-respiratory arrest, hypoxic encephalopathy. ZYPREXA dosage: 20 MG, DAILY (1/D), AFTER SUPPER. During the same period patient was treated with RISPERDAL, LEVOTOMIN, LEXOTAN, LINTON, AKINETON, NITRAZEPAM. Patient died on 12/24/2006.
Zyprexa Side Effects Report #5222559-7
ZYPREXA problem was reported by a Physician from GERMANY on Jan 16, 2007. Female patient, 29 years of age, was diagnosed with depression and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: lower limb fracture, pelvic fracture, suicide attempt. ZYPREXA dosage: 2.5 MG, UNK. During the same period patient was treated with CYMBALTA, TAVOR. Patient was hospitalized. Patient recovered.
Zyprexa Side Effects Report #5223764-6
Physician from MEXICO reported ZYPREXA problem on Jan 23, 2007. Female patient, 36 years of age, weighting 136.7 lb, was diagnosed with bipolar disorder, affective disorder and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: completed suicide. ZYPREXA dosage: unknown. During the same period patient was treated with PROZAC, VALPROATE, LITHIUM CARBONATE. Patient died on 12/23/2006.
Zyprexa Side Effects Report #5223765-8
ZYPREXA problem was reported by a Physician from AUSTRALIA on Jan 16, 2007. Female patient was diagnosed with mania and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: psychotic disorder. ZYPREXA dosage: 15 MG, DAILY (1/D). During the same period patient was treated with RISPERDAL. Patient was hospitalized. Patient recovered.
Zyprexa Side Effects Report #5223767-1
Physician from UNITED KINGDOM reported ZYPREXA problem on Jan 24, 2007. Female patient, 50 years of age, was diagnosed with mania and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: abnormal behaviour, agitation, blood pressure increased, depression, intentional overdose, liver disorder, neuroleptic malignant syndrome, renal impairment. ZYPREXA dosage: 15 MG, EACH EVENING. During the same period patient was treated with SERTRALINE, LITHIUM CARBONATE. Patient was hospitalized. Patient recovered.
Zyprexa Side Effects Report #5223838-X
ZYPREXA problem was reported by a Physician from UNITED STATES on Jan 23, 2007. Female patient, 70 years of age, was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: cerebrovascular accident, pneumonia. ZYPREXA dosage: 5 MG, UNK. During the same period patient was treated with CELEXA. Patient was hospitalized. Patient recovered.
Zyprexa Side Effects Report #5223839-1
Consumer or non-health professional from UNITED STATES reported ZYPREXA problem on Jan 24, 2007. Female patient, weighting 170.0 lb, was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: cardiac disorder, diabetes mellitus, hallucination, auditory, hypertension, overweight, palpitations, prescribed overdose, swelling. ZYPREXA dosage: 10 MG, UNK. During the same period patient was treated with ABILIFY, WELLBUTRIN, ZOLOFT. Patient was hospitalized. Patient recovered.
Zyprexa Side Effects Report #5223845-7
ZYPREXA problem was reported by a Consumer or non-health professional from UNITED STATES on Jan 24, 2007. Male patient, 15 years of age, weighting 175.0 lb, was diagnosed with autism and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: diabetes mellitus, diabetic coma, diabetic ketoacidosis, hepatitis viral, hyperglycaemia, pancreatitis, peptic ulcer perforation, weight increased. ZYPREXA dosage: 10 MG, UNK. Patient was hospitalized. Patient recovered.
Zyprexa Side Effects Report #5223889-5
Physician from UNITED STATES reported ZYPREXA problem on Jan 19, 2007. Male patient, 55 years of age, weighting 150.0 lb, was diagnosed with obsessive thoughts and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: completed suicide. ZYPREXA dosage: 5 MG, UNK. During the same period patient was treated with XANAX, LEXAPRO. Patient died on 06/24/2005.
Zyprexa Side Effects Report #5223895-0
ZYPREXA problem was reported by a Physician from JAPAN on Jan 24, 2007. Female patient, 63 years of age, weighting 110.2 lb, was diagnosed with schizophrenia, dysuria and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: cholelithiasis, eosinophil count increased, hepatic function abnormal, jaundice, lymphadenopathy. ZYPREXA dosage: 5 MG, DAILY (1/D). During the same period patient was treated with SEPAZON, ROHYPNOL, ZOTEPINE, LEXOTAN, UBRETID. Patient recovered.
Zyprexa Side Effects Report #5226302-7
Consumer or non-health professional from UNITED STATES reported ZYPREXA problem on Jan 24, 2007. Male patient, weighting 240.0 lb, was diagnosed with depression and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: catheterisation cardiac, diabetes mellitus. ZYPREXA dosage: unknown. Patient was hospitalized. Patient recovered.
Zyprexa Side Effects Report #5226303-9
ZYPREXA problem was reported by a Consumer or non-health professional from UNITED STATES on Jan 24, 2007. Male patient, 57 years of age, weighting 140.0 lb, was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: diabetes mellitus non-insulin-dependent, foot operation. ZYPREXA dosage: 10 MG, 2/D. During the same period patient was treated with QUETIAPINE FUMARATE, DEPAKOTE. Patient was hospitalized. Patient recovered.
Zyprexa Side Effects Report #5226304-0
Consumer or non-health professional from UNITED STATES reported ZYPREXA problem on Jan 24, 2007. Male patient, 57 years of age, weighting 180.0 lb, was diagnosed with nervousness and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: diabetes mellitus, diabetic coma, hyperglycaemia, hyperosmolar state, metabolic syndrome, rhabdomyolysis, transfusion. ZYPREXA dosage: 5 MG, UNK. Patient was hospitalized. Patient died on 11/15/2002.
Zyprexa Side Effects Report #5226305-2
ZYPREXA problem was reported by a Consumer or non-health professional from UNITED STATES on Jan 24, 2007. Male patient, 45 years of age, weighting 220.0 lb, was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: blood cholesterol abnormal, blood triglycerides increased, diabetes mellitus non-insulin-dependent, glycosuria, hyperglycaemia, hypertension, thrombosis, weight decreased. ZYPREXA dosage: 10 MG, UNK. During the same period patient was treated with ARIPIPRAZOLE, DEPAKOTE, BUPROPION. Patient was hospitalized. Patient recovered.
Zyprexa Side Effects Report #5226306-4
Physician from UNITED STATES reported ZYPREXA problem on Jan 24, 2007. Male patient, 29 years of age, was diagnosed with affective disorder and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: white blood cell count decreased. ZYPREXA dosage: 20 MG, DAILY (1/D). During the same period patient was treated with COUMADIN, METOPROLOL TARTRATE. Patient recovered.
Zyprexa Side Effects Report #5226307-6
ZYPREXA problem was reported by a Consumer or non-health professional from UNITED STATES on Jan 24, 2007. Male patient, 28 years of age, weighting 195.0 lb, was diagnosed with depression and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: cardiac disorder, diabetes mellitus non-insulin-dependent, hypertension, myocardial infarction. ZYPREXA dosage: 2.5 MG, UNK. Patient was hospitalized. Patient recovered.
Zyprexa Side Effects Report #5226308-8
Physician from JAPAN reported ZYPREXA problem on Jan 26, 2007. Female patient, 43 years of age, was diagnosed with schizophrenia and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: schizophrenia, white blood cell count decreased. ZYPREXA dosage: 20 MG, DAILY (1/D). Patient recovered.
Zyprexa Side Effects Report #5226309-X
ZYPREXA problem was reported by a Physician from CANADA on Jan 24, 2007. Male patient, 44 years of age, was diagnosed with schizophrenia and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: diabetic ketoacidosis, respiratory tract infection. ZYPREXA dosage: unknown. Patient was hospitalized. Patient recovered.
Zyprexa Side Effects Report #5226311-8
Physician from UNITED KINGDOM reported ZYPREXA problem on Jan 22, 2007. Male patient, 23 years of age, was diagnosed with schizophrenia, tonsillitis and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: electrocardiogram abnormal. ZYPREXA dosage: 10 MG, DAILY (1/D). During the same period patient was treated with ARIPIPRAZOLE, ERYTHROMYCIN, AMOXICILLIN. Patient recovered.
Zyprexa Side Effects Report #5226312-X
ZYPREXA problem was reported by a Consumer or non-health professional from on Jan 22, 2007. Female patient, 55 years of age, was diagnosed with bipolar disorder, pain and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: affect lability, balance disorder, epistaxis, fall, tearfulness. ZYPREXA dosage: 5 MG, EACH EVENING. During the same period patient was treated with FERROUS SULPHATE, FOLIC ACID, MAGNESIUM OXIDE, OMEPRAZOLE, OXYCODONE. Patient recovered.
Zyprexa Side Effects Report #5226314-3
Physician from JAPAN reported ZYPREXA problem on Jan 26, 2007. Female patient, 45 years of age, was diagnosed with schizophrenia and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: cardio-respiratory arrest. ZYPREXA dosage: unknown. During the same period patient was treated with RISPERDAL, SEROQUEL. Patient died.
Zyprexa Side Effects Report #5226315-5
ZYPREXA problem was reported by a Physician from GERMANY on Jan 24, 2007. Female patient, 43 years of age, was diagnosed with schizoaffective disorder and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: blood amylase increased, flatulence, lipase increased, nausea, pancreatic disorder, prescribed overdose. ZYPREXA dosage: 40MG, DAILY (1/D). During the same period patient was treated with TRANXILIUM. Patient recovered.
Zyprexa Side Effects Report #5226321-0
Physician from UNITED KINGDOM reported ZYPREXA problem on Jan 23, 2007. Male patient, 86 years of age, weighting 132.3 lb, was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: leukocytosis, neuroleptic malignant syndrome. ZYPREXA dosage: 5 MG, UNK. During the same period patient was treated with CLOPIXOL DEPOT, PRIADEL. Patient was hospitalized and became disabled. Patient died.
Zyprexa Side Effects Report #5227547-2
ZYPREXA problem was reported by a Physician from FRANCE on Jan 25, 2007. Male patient, 70 years of age, was diagnosed with mania and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: abasia. ZYPREXA dosage: 5 MG, DAILY (1/D). During the same period patient was treated with TERALITHE. Patient recovered.
Zyprexa Side Effects Report #5227548-4
Physician from UNITED STATES reported ZYPREXA problem on Jan 22, 2007. Female patient, 55 years of age, weighting 155.0 lb, was diagnosed with schizoaffective disorder and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: circulatory collapse, prescribed overdose. ZYPREXA dosage: 30 MG, UNK. During the same period patient was treated with DEPAKOTE. Patient died on 07/26/2006.
Zyprexa Side Effects Report #5227549-6
ZYPREXA problem was reported by a Physician from UNITED KINGDOM on Jan 23, 2007. Female patient, 22 years of age, was diagnosed with sedation and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: respiratory depression, somnolence. ZYPREXA dosage: 10 MG, UNK. During the same period patient was treated with DIAZEPAM, LORAZEPAM. Patient recovered.
Zyprexa Side Effects Report #5227550-2
Consumer or non-health professional from UNITED STATES reported ZYPREXA problem on Jan 23, 2007. Female patient, weighting 270.0 lb, was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: diabetes mellitus, epilepsy. ZYPREXA dosage: 5 MG, UNK. Patient was hospitalized. Patient recovered.
Zyprexa Side Effects Report #5227551-4
ZYPREXA problem was reported by a Physician from UNITED STATES on Jan 25, 2007. Female patient, child 3 years of age, was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: accidental overdose, biopsy kidney, coma, protein urine present, pyrexia, renal failure, viral infection. ZYPREXA dosage: unknown. Patient was hospitalized. Patient recovered.
Zyprexa Side Effects Report #5227588-5
Consumer or non-health professional from UNITED STATES reported ZYPREXA problem on Jan 25, 2007. Female patient, 61 years of age, weighting 190.0 lb, was diagnosed with depression and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: diabetes mellitus, diabetic coma, intestinal haemorrhage, metabolic disorder, vision blurred. ZYPREXA dosage: 2.5 MG, 2/D. Patient was hospitalized. Patient recovered.
Zyprexa Side Effects Report #5227589-7
ZYPREXA problem was reported by a Consumer or non-health professional from UNITED STATES on Jan 25, 2007. Female patient, 49 years of age, weighting 175.0 lb, was diagnosed with depression and was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: diabetes mellitus, hyperinsulinism, hypoglycaemia, lactic acidosis, metabolic disorder, vision blurred. ZYPREXA dosage: 2.5 MG, UNK. During the same period patient was treated with RISPERDAL, TRIFLUOPERAZINE, BUPROPION, SYMBYAX, SERTRALINE, TRAZODONE. Patient recovered.
Zyprexa Side Effects Report #5227591-5
Physician from UNITED STATES reported ZYPREXA problem on Jan 25, 2007. Male patient was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: amputation, diabetes mellitus. ZYPREXA dosage: 10 MG, 2/D. During the same period patient was treated with PREDNISONE, ABILIFY. Patient recovered.
Zyprexa Side Effects Report #5228235-9
ZYPREXA problem was reported by a Consumer or non-health professional from UNITED STATES on Jan 25, 2007. Female patient, weighting 210.0 lb, was treated with ZYPREXA. After drug was administered, patient experienced the following problems/side effects: deep vein thrombosis, diabetes mellitus. ZYPREXA dosage: 10 MG, UNK. Patient was hospitalized. Patient recovered.
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Drug Information: Olanzapine
URL of this page: http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a601213.html
(oh lan' za peen)IMPORTANT WARNING:
| [Posted 05/02/2007] FDA notified healthcare professionals that the Agency proposed that makers of all antidepressant medications update the existing black box warning on the prescribing information for their products to include warnings about the increased risks of suicidal thinking and behavior in young adults ages 18 to 24 years old during the first one to two months of treatment. The proposed labeling changes also state that scientific data did not show this increased risk in adults older than 24 years of age and that adults 65 years of age and older taking antidepressants have a decreased risk of suicidality. The proposed updates apply to the entire category of antidepressants. Individuals currently taking prescribed antidepressant medications should not stop taking them and should notify their healthcare professional if they have concerns. Manufacturers of antidepressant medications will have 30 days to submit their revised product labeling and revised Medication Guides to FDA for review. See the FDA press release for the list of products affected by the proposed antidepressant product labeling changes. For more information visit the FDA website at: http://www.fda.gov/medwatch/safety/2007/safety07.htm#Antidepressant, http://www.fda.gov/bbs/topics/NEWS/2007/NEW01624.html and http://www.fda.gov/cder/drug/antidepressants/default.htm. |
IMPORTANT WARNING:
| Studies have shown that older adults with dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and that may cause changes in mood and personality) who take antipsychotics (medications for mental illness) such as olanzapine have an increased chance of death during treatment. Older adults with dementia may also have a greater chance of having a stroke or mini-stroke during treatment. If you experience any of the following symptoms, call your doctor immediately: slow or difficult speech, sudden dizziness or faintness, or weakness or numbness of an arm or leg.Olanzapine is not approved by the Food and Drug Administration (FDA) for the treatment of behavior disorders in older adults with dementia. Talk to the doctor who prescribed this medication if you, a family member, or someone you care for has dementia and is taking olanzapine. For more information visit the FDA website: http://www.fda.gov/cder |
Why is this medication prescribed?
Pending revision, the material in this section should be considered in light of more recently available information in the MedWatch notification at the beginning of this monograph.
Olanzapine is used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). It is also used to treat bipolar disorder (manic depressive disorder; a disease that causes episodes of depression, episodes of mania, and other abnormal moods). Olanzapine is in a class of medications called atypical antipsychotics. It works by changing the activity of certain natural substances in the brain.
How should this medicine be used?
Olanzapine comes as a tablet and an orally disintegrating tablet (tablet that dissolves quickly in the mouth) to take by mouth. It is usually taken once a day with or without food. Take olanzapine at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take olanzapine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Do not try to push the orally disintegrating tablet through the foil. Instead ,use dry hands to peel back the foil packaging. Immediately take out the tablet and place it in your mouth. The tablet will quickly dissolve and can be swallowed with or without liquid.
Your doctor may start you on a low dose of olanzapine and gradually increase your dose.
Olanzapine may help control your symptoms, but it will not cure your condition. It may take several weeks or longer before you feel the full benefit of olanzapine. Continue to take olanzapine even if you feel well. Do not stop taking olanzapine without talking to your doctor. Your doctor will probably want to decrease your dose gradually.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Pending revision, the material in this section should be considered in light of more recently available information in the MedWatch notification at the beginning of this monograph.
Before taking olanzapine,
- tell your doctor and pharmacist if you are allergic to olanzapine or any other medications.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antidepressants; antihistamines; carbamazepine (Tegretol); dopamine agonists such as bromocriptine (Parlodel), cabergoline (Dostinex), levodopa (Dopar, Larodopa), pergolide (Permax), and ropinirole (Requip); fluoroquinolone antibiotics including ciprofloxacin (Cipro), gatifloxacin (Tequin) (not available in the United States), levofloxacin (Levaquin), norfloxacin (Noroxin), ofloxacin (Floxin), others; fluvoxamine (Luvox); ipratropium (Atrovent); medications for anxiety, hypertension, irritable bowel disease, mental illness, motion sickness, Parkinson's disease, seizures, ulcers, or urinary problems; omeprazole (Prilosec); rifampin (Rifadin); sedatives; sleeping pills; ticlopidine (Ticlid); and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you use or have ever used street drugs or have overused prescription medications and if you have or have ever had a stroke, a mini-stroke, heart disease or a heart attack, an irregular heartbeat, seizures, breast cancer, any condition that makes it difficult for you to swallow, high or low blood pressure, liver or prostate disease, paralytic ileus (condition in which food cannot move through the intestine); or glaucoma (an eye condition), or if you or anyone in your family has or has ever had diabetes. Also tell your doctor if you have ever had to stop taking a medication for mental illness because of severe side effects.
- tell your doctor if you are pregnant or plan to become pregnant. If you become pregnant while taking olanzapine, call your doctor. Do not breast-feed if you are taking olanzapine.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking olanzapine.
- you should know that olanzapine may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.
- you should know that alcohol can add to the drowsiness caused by this medication. Do not drink alcohol while taking olanzapine.
- tell your doctor if you use tobacco products. Cigarette smoking may decrease the effectiveness of this medication.
- you should know that you may experience hyperglycemia (increases in your blood sugar) while you are taking this medication, even if you do not already have diabetes. If you have schizophrenia, you are more likely to develop diabetes than people who do not have schizophrenia, and taking olanzapine or similar medications may increase this risk. Tell your doctor immediately if you have any of the following symptoms while you are taking olanzapine: extreme thirst, frequent urination, extreme hunger, blurred vision, or weakness. It is very important to call your doctor as soon as you have any of these symptoms, because high blood sugar can cause a serious condition called ketoacidosis. Ketoacidosis may become life-threatening if it is not treated at an early stage. Symptoms of ketoacidosis include: dry mouth, nausea and vomiting, shortness of breath, breath that smells fruity, and decreased consciousness.
- you should know that olanzapine may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking olanzapine. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.
- you should know that olanzapine may make it harder for your body to cool down when it gets very hot. Tell your doctor if you plan to do vigorous exercise or be exposed to extreme heat.
- if you have phenylketonuria (PKU, an inherited condition in which a special diet must be followed to prevent mental retardation), you should know that the orally disintegrating tablets contain phenylalanine.
What special dietary instructions should I follow?
Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine.
Be sure to drink plenty of water every day while you are taking this medication.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
Pending revision, the material in this section should be considered in light of more recently available information in the MedWatch notification at the beginning of this monograph.
Olanzapine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- drowsiness
- dizziness
- restlessness
- unusual behavior
- depression
- difficulty falling asleep or staying asleep
- weakness
- difficulty walking
- constipation
- weight gain
- dry mouth
- pain in arms, legs, back, or joints
Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNING section or the SPECIAL PRECAUTIONS section, call your doctor immediately:
- seizures
- changes in vision
- swelling of the arms, hands, feet, ankles, or lower legs
- unusual movements of your face or body that you cannot control
- fever
- very stiff muscles
- excess sweating
- fast or irregular heartbeat
- rash
- hives
- difficulty breathing or swallowing
Olanzapine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/index.html] or by phone [1-800-332-1088].
What storage conditions are needed for this medicine?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Always store the orally disintegrating tablets in their sealed package, and use them immediately after opening the package. Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of emergency/overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Symptoms of overdose may include:
- drowsiness
- slurred speech
- agitation
- fast heartbeat
- sudden movements that you cannot control
- coma (loss of consciousness for a period of time)
What other information should I know?
Pending revision, the material in this section should be considered in light of more recently available information in the MedWatch notification at the beginning of this monograph.
Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to olanzapine.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
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