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BUPROPION Tablet, Extended Release [Zydus Pharmaceuticals (USA) Inc.]

Updated Date: Feb 18, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Asystole shortly after intravenous fat emulsion for overdose: causation or coincidence?

3 out of 5 stars Asystole Immediately Following Intravenous Fat Emulsion for Overdose. Cole JB et al. J Med Toxicol 2014 Feb 12. [Epub ahead of print] Abstract This case paper describes 2 patients who developed asystolic within 60 seconds of being given intravenous fat emulsion (IFE) bolus for treatment of severe cardiotoxicity. Both patients had return of spontaneous circulation (ROSC) after several minutes of cardiopulmonary resuscitation. Unfortunately, both patients died days after admission from multisystem organ failure. Patient A, a 50-year-old woman, had ingested an undetermined about of metoprolol and bupropion in a suicide attempt. She seized and then developed bradycardia and hypotension unresponsive to multiple interventions (fluid, glucagon, insulin). Within 30 sec of recei...

Effects of bupropion and pramipexole on cell proliferation in the hippocampus of adrenocorticotropic hormone-treated rats.

In this study, we used the mitotic marker 5-bromo-2'-deoxyridine to investigate the effects of bupropion and pramipexole on cell proliferation in the subgranular zone of the hippocampal dentate gyrus following chronic treatment with ACTH. The ACTH treatment for 14�??d decreased adult hippocampal cell proliferation. The chronic administration of bupropion for 14�??d blocked the loss of cell proliferation resulting from the chronic treatment with ACTH, whereas pramipexole did not. The administration of bupropion may have treatment-resistant antidepressive properties, which may be partly attributed to the normalization of hippocampal cell proliferation. PMID: 24492730 [PubMed - in process] (Source: Biological and Pharmaceutical Bulletin)

Asystole Immediately Following Intravenous Fat Emulsion for Overdose.

This report adds only case experience, not clarity. We report two cardiac arrests that were temporally associated with IFE. PMID: 24519703 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)

Nicotinic receptor antagonists as treatments for nicotine abuse.

Authors: Crooks PA, Bardo MT, Dwoskin LP Abstract Despite the proven efficacy of current pharmacotherapies for tobacco dependence, relapse rates continue to be high, indicating that novel medications are needed. Currently, several smoking cessation agents are available, including varenicline (Chantix®), bupropion (Zyban®), and cytisine (Tabex®). Varenicline and cytisine are partial agonists at the α4β2* nicotinic acetylcholine receptor (nAChR). Bupropion is an antidepressant but is also an antagonist at α3β2* ganglionic nAChRs. The rewarding effects of nicotine are mediated, in part, by nicotine-evoked dopamine (DA) release leading to sensitization, which is associated with repeated nicotine administration and nicotine addiction. Receptor antagonists that selectivity target ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Bupropion and bupropion analogs as treatments for CNS disorders.

Authors: Carroll FI, Blough BE, Mascarella SW, Navarro HA, Lukas RJ, Damaj MI Abstract Bupropion, introduced as an antidepressant in the 1980s, is also effective as a smoking cessation aid and is beneficial in the treatment of methamphetamine addiction, cocaine dependence, addictive behaviors such as pathological gambling, and attention deficit hyperactivity disorder. (2S,3S)-hydroxybupropion is an active metabolite of bupropion produced in humans that contributes to antidepressant and smoking cessation efficacy and perhaps benefits in other CNS disorders. Mechanisms underlying its antidepressant and smoking abstinence remain elusive. However, it seems likely that efficacy is due to a combination of the effects of bupropion and/or its active metabolite (2S,3S)-hydroxybupropion invo...

Smoking Cessation

Cigarette smoking is a major preventable cause of morbidity and mortality. It is the major risk factor for chronic obstructive pulmonary disease in the developed world. Smoking is a chronic relapsing disease. Optimal treatment includes nonpharmacologic support, together with pharmacotherapy. All clinicians should be comfortable with the use of nicotine replacement therapy, bupropion, and varenicline. Second-line therapies can be used by those familiar with their use. Effective use of these medications requires their integration into an effective management plan, which is likely to be a long-term undertaking, involving several cycles of remission and relapse. (Source: Clinics in Chest Medicine)

BUPROPION HYDROCHLORIDE Tablet, Film Coated [BluePoint Laboratories]

Updated Date: Feb 7, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BUPROPION HYDROCHLORIDE Tablet, Film Coated, Extended Release [Jubilant Cadista Pharmaceuticals Inc.]

Updated Date: Feb 3, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BUPROPION HYDROCHLORIDE Tablet, Film Coated, Extended Release [REMEDYREPACK INC. ]

Updated Date: Jan 31, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

WELLBUTRIN (Bupropion Hydrochloride) Tablet, Film Coated [REMEDYREPACK INC. ]

Updated Date: Jan 31, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

The long�?�term cost�?�effectiveness of varenicline (12�?�week standard course and 12 + 12�?�week extended course) vs. other smoking cessation strategies in Canada

ConclusionsThe standard and extended courses of varenicline are decidedly cost�?�effective treatment regimes compared with alternative smoking cessation interventions and can provide significant cost savings to the healthcare system. (Source: International Journal of Clinical Practice)

BUPROPION HYDROCHLORIDE Tablet, Film Coated, Extended Release [Preferred Pharmaceuticals, Inc.]

Updated Date: Jan 29, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

bupropion, Wellbutrin, Wellbutrin SR, Wellbutrin XL, Zyban, Aplenzin, Forfivo XL

Title: bupropion, Wellbutrin, Wellbutrin SR, Wellbutrin XL, Zyban, Aplenzin, Forfivo XLCategory: MedicationsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 1/22/2014 12:00:00 AM (Source: MedicineNet Depression General)

Varenicline may reduce negative effect while aiding smoking cessation

Commentary on: Cinciripini PM, Robinson JD, Karam-Hage M, et al.. Effects of varenicline and bupropion sustained-release use plus intensive smoking cessation counseling on prolonged abstinence from smoking and on depression, negative affect, and other symptoms of nicotine withdrawal. JAMA Psychiatry 2013;70:522&ndash;33. Context Cigarette smoking remains the most important cause of preventable morbidity and premature mortality, with projected annual tobacco-attributable deaths worldwide estimated to reach nearly 6.5 million by 2015.1 The most effective treatment for tobacco dependence is combined behavioural and pharmacological therapy, which is widely available yet underemployed. Most attempts to quit smoking are still unaided, and surveys suggest that pharmacological treatment is often n...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Zydus Cadila gets USFDA nod for anti-depressant drug

Drug major Zydus Cadila has received approval from the US health regulator to market Bupropion Hydrochloride extended-release tablets, an anti-depressant medicine, in the American market. (Source: The Economic Times Healthcare and Biotech News)

Resolution of sleepiness and fatigue: A comparison of bupropion and selective serotonin reuptake inhibitors in subjects with major depressive disorder achieving remission at doses approved in the European Union

Unlike selective serotonin reuptake inhibitors (SSRIs), bupropion may be classified as a dual noradrenaline and dopamine reuptake inhibitor, a difference with potential implications for the treatment of residual sleepiness and fatigue in major depressive disorder (MDD). Post-hoc analysis of subjects with remitted MDD was performed on data pooled from six double-blind, randomized trials comparing the European Union (EU)-approved dose of &le;300 mg/day bupropion with SSRIs (sertraline, paroxetine or escitalopram) for the resolution of sleepiness and fatigue. Hypersomnia score was defined as the sum of scores of the Hamilton Depression Rating Scale (HDRS) items 22, 23, and 24; fatigue score as HDRS item 13 score; and remission as HDRS-17&le;7. Similar proportions of bupropion- and SSRI-treate...

Safety of Varenicline in Patients With Cardiovascular Disease

Smoking cessation lowers the risk of death substantially in patients with cardiovascular disease. Although varenicline is an effective medication for smoking cessation, its safety in this population has been questioned and evaluated in several studies. In 2 randomized controlled trials of patients with cardiovascular disease, the rates of serious cardiovascular events were up to 2% higher in patients receiving varenicline than placebo, though the differences were not statistically significant. In the first meta-analysis of mostly trials involving patients with a history of cardiovascular disease, varenicline was found to significantly increase the risk of cardiovascular events by 72%; however, a second meta-analysis did not find a significant increased risk. In an observational study, vare...

Serotonin Syndrome: Is It a Reason to Avoid the Use of Tramadol With Antidepressants?

Conclusions: Review of the available case reports of tramadol combined with antidepressant drugs in therapeutic doses indicates caution in regard to the potential for SS but does not constitute a contraindication to their use. Tramadol is only contraindicated in combination with MAOIs but not other antidepressants in common use today. These case reports do suggest several factors associated with a greater risk of SS, including increased age, higher dosages, and use of concomitant potent cytochrome P450 2D6 inhibitors. Tramadol can be safely combined with antidepressants; however, monitoring and counseling patients are prudent when starting a new serotonergic agent or when doses are increased. (Source: Journal of Pharmacy Practice)

BUPROPION HYDROCHLORIDE Tablet, Film Coated, Extended Release [St Marys Medical Park Pharmacy]

Updated Date: Jan 16, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

BUPROPION HYDROCHLORIDE Tablet, Film Coated, Extended Release [Mylan Pharmaceuticals Inc.]

Updated Date: Jan 10, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Drug Combo Boosts Early Quit Rates in SmokersDrug Combo Boosts Early Quit Rates in Smokers

Combining varenicline with bupropion may boost early quit rates compared with varenicline alone; heavier smokers most likely to benefit. Medscape Medical News (Source: Medscape Psychiatry Headlines)

Antidepressants for smoking cessation.

CONCLUSIONS: The antidepressants bupropion and nortriptyline aid long-term smoking cessation. Adverse events with either medication appear to rarely be serious or lead to stopping medication. Evidence suggests that the mode of action of bupropion and nortriptyline is independent of their antidepressant effect and that they are of similar efficacy to nicotine replacement. Evidence also suggests that bupropion is less effective than varenicline, but further research is needed to confirm this finding. Evidence suggests that neither selective serotonin reuptake inhibitors (e.g. fluoxetine) nor monoamine oxidase inhibitors aid cessation. PMID: 24402784 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)

Combined Therapy Benefits Cigarette Smokers Trying to Quit Compared to Monotherapy

ROCHESTER, Minn. �?? Jan. 7, 2014 �?? Among cigarette smokers, combining the smoking cessation medications varenicline and bupropion, compared with varenicline alone, resulted in higher smoking abstinence rates for one outcome but not the other at three and six months; rates were similar at one year, according to a Mayo Clinic study published this month [...] (Source: Mayo Clinic Research News)

Depressive-like behavior induced by tumor necrosis factor-α is abolished by agmatine administration.

This study investigated the ability of agmatine administered orally to abolish the depressive-like behavior induced by the administration of the pro-inflammatory cytokine, tumor necrosis factor (TNF-α) in mice. In control animals, agmatine (0.001, 0.01, 0.1, and 1mg/kg) reduced the immobility time in the tail suspension test (TST). Acute administration of TNF-α (0.001fg/mouse, i.c.v.) increased immobility time in the TST, indicative of a depressive-like behavior, and agmatine (0.0001, 0.1, and 1mg/kg) prevented this effect. Additionally, we examined the effects of the combined administration of sub-effective doses of agmatine with antidepressants, the NMDA receptor antagonist MK-801 and the neuronal nitric oxide synthase inhibitor 7-nitroindazole (7-NI) in mice exposed to either TNF-α o...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

BUPROPION HYDROCHLORIDE Tablet, Film Coated, Extended Release [Aidarex Pharmaceuticals LLC]

Updated Date: Jan 2, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BUPROPION HYDROCHLORIDE Tablet, Film Coated [Aidarex Pharmaceuticals LLC]

Updated Date: Jan 2, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BUPROPION HYDROCHLORIDE SR (SR) (Bupropion Hydrochloride) Tablet, Film Coated, Extended Release [Aidarex Pharmaceuticals LLC]

Updated Date: Jan 2, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Mechanism of an unusual, but clinically significant, digoxin�?�bupropion drug interaction

This article is protected by copyright. All rights reserved. (Source: Biopharmaceutics and Drug Disposition)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Bupropion Linked With Delayed-Onset UrticariaBupropion Linked With Delayed-Onset Urticaria

Bupropion may put patients at risk for delayed-onset urticaria, a nationwide study from Taiwan has shown. Reuters Health Information (Source: Medscape Medical News Headlines)

Naltrexone/Bupropion Combination in Obese Patients With T2DMNaltrexone/Bupropion Combination in Obese Patients With T2DM

Can this antidepressant/opioid receptor antagonist combination product promote weight loss in patients with T2DM? Diabetes Care (Source: Medscape Today Headlines)

A case of hypomania during nicotine cessation treatment with bupropion.

We describe the case of a 67-year-old man known for dysthymic disorder in remission on quetiapine and venlafaxine who experienced a first lifetime episode of hypomania with the introduction of bupropion SR for smoking cessation. To the best of our knowledge, this is the first case report of bupropion-induced mood shift when used specifically for nicotine cessation in a nonbipolar patient. This case highlights the need for clinicians who prescribe bupropion for smoking cessation to perform regular and systematic mood follow-ups during treatment. These follow-ups could even be more important when bupropion is selected to quit smoking in a patient already taking an antidepressant. PMID: 24359680 [PubMed - as supplied by publisher] (Source: Addiction Science and Clinical Practice)

�??Real�?�world�?? effectiveness of smoking cessation treatments: a population study

ConclusionsAfter adjusting for major confounding variables such as tobacco dependence, smokers in England who use a combination of behavioural support and pharmacotherapy in their quit attempts have almost three times the odds of success than those who use neither pharmacotherapy nor behavioural support. Smokers who buy nicotine replacement therapy over the counter with no behavioural support have similar odds of success in stopping as those who stop without any aid. (Source: Addiction)

Antidepressant-Induced Liver Injury: A Review for Clinicians.

CONCLUSIONS Although an infrequent event, DILI from antidepressant drugs may be irreversible, and clinicians should be aware of it. Aminotransferase surveillance is the most useful tool for detecting DILI, and prompt discontinuation of the drug responsible is essential. The results of antidepressant liver toxicity in all phases of clinical trials should be available and published. Further research is needed before any new and rigorously founded recommendations can be made. PMID: 24362450 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Bupropion perceived as a stimulant by two patients with a previous history of cocaine misuse.

Conclusions. The issue of bupropion cue generalisation to cocaine needs further elucidation. People with past cocaine addiction need to be informed on the potential of bupropion to elicit cocaine-like cues and be invited to adhere to medical prescription, because bupropion has been associated with fatalities in some cases. PMID: 24334787 [PubMed - in process] (Source: Annali dell'Istituto Superiore di Sanita)

New and Emerging Drug Molecules Against Obesity

Obesity has become a growing pandemic of alarming proportions in the developed and developing countries over the last few decades. The most perturbing fact regarding obesity is the increased predisposition for coronary artery disease, congestive heart failure and sudden cardiac death. The modest efficacy of current anti-obesity agents such as orlistat and the increasing withdrawals of several anti-obesity agents such as sibutramine, rimonabant have led to huge gaps in the pharmacotherapy of obesity. Lorcaserin and Phentermine-topiramate combination (phen-top) are two drugs approved by US FDA in 2012. Lorcaserin, a 5HT2C agonist has moderate efficacy with an acceptable safety profile. Clinical trials with Phen-top have shown a reasonable efficacy but at the cost of risks such as teratogenic...

Serum creatinine elevation caused by bupropion.

Authors: Kinalp C, Kurultak I, Ceri M, Keskinel I PMID: 24343039 [PubMed - as supplied by publisher] (Source: Wiener Klinische Wochenschrift)

'No serious heart risks' linked to smoking cessation therapies

The American Heart Association claims that three different types of smoking cessation therapies do not pose serious heart risks, quashing concerns that certain products may increase the risks of heart attack, stroke or heart-related death.Researchers looked at the results of 63 clinical trials involving 30, 508 people who were quitting smoking using either nicotine replacement gums and patches, the nicotine addiction treatment varenicline (Chantix), or taking the antidepressant bupropion (Wellbutrin), which can reduce cravings and other unwanted withdrawal effects. (Source: Health News from Medical News Today)

Comparison of the Antidepressive Effects of Trans-Resveratrol and 5-Methoxy-7H-dibenzo[de,h]quinolin-7-one.

In this study we evaluate the in vivo antidepressant effect of a natural phenolic compound, trans-resveratrol, and a synthetic derivative from Menispermum dauricum DC (Menispermaceae) 5-methoxy-7H-dibenzo[de,h]quinolin-7-one known as 5-methoxyoxoisoaporphine (OXO 4). The antidepressant-like effect of trans-resveratrol and OXO 4 were evaluated through a Forced Swimming Test (FST), and they were compared with reference antidepressants: imipramine, desipramine, nomifensine, bupropion, nisoxetine, citalopram and moclobemide. Trans-resveratrol (10 mg/kg, intraperitoneally i.p. significantly decreased the immobility time in mouse model of despair test (69.03 ~+mn~ 8.74 sec) p&lt;0.05, as well as OXO 4 (1mg/kg, i.p. (60.92 ~+mn~ 11.37 sec); p&lt;0.05. We also evaluate the OXO 4 at 15, 30 and 45 min. af...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Utilization of Evidence-Based Therapy for Acute Coronary Syndrome in High-Income and Low/Middle-Income Countries

In conclusion, patients with ACS in low/middle-income countries were less likely to be revascularized and to receive evidence-based medications at discharge. Further studies are needed to understand the underutilization of procedures and evidence-based medications in low/middle-income countries. (Source: The American Journal of Cardiology)

Cardiovascular Events Associated with Smoking Cessation Pharmacotherapies: A Network Meta-Analysis.

CONCLUSIONS: Smoking cessation therapies do not appear to raise the risk of serious CVD events. PMID: 24323793 [PubMed - as supplied by publisher] (Source: Circulation)

Bupropion response on sleep quality in patients with depression: Implications for increased cardiovascular disease risk

Abstract: Depression could be an independent risk factor for cardiovascular disease. We assessed bupropion response in depressed patients by polysomnography (PSG) and cardiopulmonary coupling (CPC) variables. Nineteen subjects participated in a two-session, two consecutive night PSG protocol. Participants received either placebo or bupropion-SR 150mg, orally, in a randomized, double-blind cross-over fashion on night two. Outcome variables were: sleep stages, REM latency, stable, unstable sleep and very low frequency coupling (VLFC). CPC analysis uses heart rate variability and the electrocardiogram's R-wave amplitude fluctuations associated with respiration to generate frequency maps. Bupropion increased REM latency (p=0.043) but did not impact PSG sleep continuity, architecture and CPC va...

Lipid rescue therapy can interfere with critical lab values

3 out of 5 stars Caution with interpreting laboratory results after lipid rescue therapy. Punja M et al. Am J Emerg Med 2013 Oct;1536.e1-1536.e1 Reference (No abstract available) This case report describes a 54-year-old man who presented to the emergency department after ingesting a suicidal ingestion of diphenhydramine, amitriptyline, and acetaminophen (APAP). On arrival the patient had evidence of cardiotoxicity with unstable vital signs and a prolonged QRS interval (136 msec). His initial aspartate aminotransferase (AST) level was elevated (138 U/L). After treatment with sodium bicarbonate, N-acetylcysteine (NAC), and 20% intravenous lipid rescue therapy (apparently &lt; 2 ml/kg) an AST level was repeated and was undetectable. Based partially on this result, treatment with NAC was st...

[Original Articles] Relationship Between Obesity and Depression: Characteristics and Treatment Outcomes With Antidepressant Medication

Conclusions BMI was related to clinical presentation and prevalence of comorbidities, but not antidepressant outcomes. Lower BMI classes had more psychiatric comorbidities, potentially obscuring the relationship between BMI and antidepressant effects. Trial Registration ClinicalTrials.gov identifier: NCT00590863 (Source: Psychosomatic Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Bupropion-SR for Smoking Reduction and Cessation in Alcohol-Dependent Outpatients: A Naturalistic, Open-Label Study.

Conclusion: Bupropion-SR may be helpfulto quit or reduce smoking for recently abstinent AD individuals. PMID: 24218993 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)

Managing tobacco use: the neglected cardiovascular disease risk factor

Cigarette smoking is a major risk factor for cardiovascular disease (CVD) and the leading avoidable cause of death worldwide. Exposure to secondhand smoke (SHS) increases the risk of CVD among non-smokers. Smoking cessation benefits all smokers, regardless of age or amount smoked. The excess risk of CVD is rapidly reversible, and stopping smoking after a myocardial infarction reduces an individual's risk of CVD mortality by 36% over 2 years. Smoking cessation is a key component of primary and secondary CVD prevention strategies, but tobacco use often receives less attention from cardiologists than other risk factors, despite the availability of proven treatments that improve smoking cessation rates. Both psychosocial counselling and pharmacotherapy are effective methods to help smokers qui...

Naltrexone/Bupropion combination therapy in overweight or obese patients with major depressive disorder: results of a pilot study.

Conclusion: Twenty-four weeks of open-label NB32 therapy with dietary and behavioral counseling was associated with improvement in depressive symptoms and reduced body weight in overweight/obese women with MDD. Trial Registration: ClinicalTrials.gov Identifier: NCT00624858. PMID: 24171147 [PubMed] (Source: Primary Care)

Tennessee Health Plan Tobacco Cessation Coverage

ConclusionIn 2012, Tennessee fell short of Healthy People goals for total managed care and comprehensive TennCare coverage of smoking cessation. If Tennessee mandates that all health plans provide full coverage, 481,900 smokers may immediately be in a better position to quit. (Source: Public Health Nursing)

Effect of uremic serum and uremic toxins on drug metabolism in human microsomes.

In this study, the direct inhibitory effect of serum from chronic renal failure (CRF) patients receiving dialysis was evaluated in CYP3A4 (testosterone) and CYP2B6 (bupropion) metabolism assays. Human liver microsomes were incubated with ultrafiltered serum collected pre- and post-hemodialysis from ten CRF patients. Additionally, several uremic toxins were evaluated in the CYP3A4 assay. In only three patients was there a significant decrease or increase in testosterone or bupropion metabolism post-dialysis. Urea, mannitol, guanidine, homocysteine, uridine and creatinine had no effect on CYP3A4 metabolism. CMPF, hippuric acid and p-cresol had IC50 values that fell within CRF patient plasma concentrations. The IC50 values for indoxyl sulfate and indole-3-acetic acid were greater than CRF pla...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effects of Naltrexone Sustained- Release/Bupropion Sustained Release Combination Therapy on Body Weight and Glycemic Parameters in Overweight and Obese Patients With Type 2 Diabetes.

CONCLUSIONSNB therapy in overweight/obese patients with type 2 diabetes induced weight loss, which was associated with improvements in glycemic control and select cardiovascular risk factors and was generally well tolerated with a safety profile similar to that in patients without diabetes. PMID: 24144653 [PubMed - as supplied by publisher] (Source: Diabetes Care)

bupropion hydrochloride extended release (Forfivo XL)

Title: bupropion hydrochloride extended release (Forfivo XL)Category: MedicationsCreated: 10/16/2013 1:31:00 PMLast Editorial Review: 10/16/2013 1:31:29 PM (Source: MedicineNet Depression General)

Bupropion diversion and misuse in the correctional facility - Hilliard WT, Barloon L, Farley P, Penn JV, Koranek A.

The antidepressant bupropion plays an important role in the treatment of mental health disorders. It is well known that incarcerated individuals are at increased risk of experimenting with psychiatric medications and it is imperative for prescribers and cl... (Source: SafetyLit: All (Unduplicated))

Assessment of Effects of Chronic Hydrogen Sulfide Poisoning on Cytochrome P450 Isoforms Activity of Rats by Cocktail Approach.

Authors: Wang X, Chen X, Chen M, Hu G, Ma J, Pan J, Hu L, Lin G Abstract Hydrogen sulfide (H2S) is one of the neurotoxic gases with suffocating and irritating. Its main target organs of toxic effects are the central nervous system and respiratory system. Cocktail method was used to evaluate the influence of chronic hydrogen sulfide poisoning on the activities of cytochrome P450 (CYP450) isoforms CYP1A2, CYP2C9, CYP2B6 and CYP2D6, which were reflected by the changes of pharmacokinetic parameters of 4 specific probe drugs phenacetin, tolbutamide bupropion and metroprolol, respectively. The experimental rats were randomly divided into two groups, control group and chronic hydrogen sulfide poisoning group. The chronic hydrogen sulfide poisoning group rats were inhaled 20�??ppm for 1�??...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Challenging sequential approach to treatment resistant depression: Cost-utility analysis based on the Sequenced Treatment Alternatives to Relieve Depression (STAR��?D) trial

This study is a cost-utility analysis (CUA) of different second-line approaches. In a simulated trial outpatients with MDD were treated with citalopram for 13 weeks (level 1), then based on two alternative algorithms implemented from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study. : citalopram was continued until study endpoint (week 26). : patients who remitted during level 1 continued citalopram. Those who did not remit could opt for switching to another antidepressant (venlafaxine; sertraline) (b1) or adding bupropion to citalopram treatment (augmentation; b2). increased remission rate by 10.6% over (number needed to treat: 9.9; sensitivity range: 9.1�??12.5). As a comparison, differences between active antidepressants and placebo are associated with NNT value...

For smoking cessation in patients with current or past depression varenicline proves safe and effective

Varenicline is safe and effective to help smokers with current or past major depression quit smoking. Approximately half of smokers seeking treatment have a history of depression. This is a clinically important relationship because depression and smoking are among the leading causes of disability and death in the world and having depression makes quitting smoking more difficult. Varenicline has proven more effective than bupropion for smoking cessation, but because of its mechanism of action, there are concerns about the safety of varenicline in patients with psychiatric disorders... (Source: Health News from Medical News Today)

The International Society for Bipolar Disorders (ISBD) Task Force Report on Antidepressant Use in Bipolar Disorders.

CONCLUSIONS Because of limited data, the task force could not make broad statements endorsing antidepressant use but acknowledged that individual bipolar patients may benefit from antidepressants. Regarding safety, serotonin reuptake inhibitors and bupropion may have lower rates of manic switch than tricyclic and tetracyclic antidepressants and norepinephrine-serotonin reuptake inhibitors. The frequency and severity of antidepressant-associated mood elevations appear to be greater in bipolar I than bipolar II disorder. Hence, in bipolar I patients antidepressants should be prescribed only as an adjunct to mood-stabilizing medications. PMID: 24030475 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)

Varenicline, Smoking Cessation, and Neuropsychiatric Adverse Events.

CONCLUSIONS This analysis revealed no evidence that varenicline is associated with adverse neuropsychiatric events. The evidence supports the superior efficacy of varenicline relative to both placebo and bupropion, indicating considerable benefit without evidence of risk of serious neuropsychiatric adverse events, in individuals with and without a recent history of a psychiatric disorder. PMID: 24030388 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)

Can E-Cigarettes Help Smokers Quit?

E-cigarettes create controversy and profits - almost equally. New data argue they can help people quit smoking - but will they also promote it?read more (Source: Psychology Today Addiction Center)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

The Antidepressants Fluoxetine and Bupropion Differentially Affect Proceptive Behavior in the Naturally Cycling Female Rat

ConclusionsThe motivational components of female sexual behavior are more sensitive than the receptive components to the inhibitory actions of fluoxetine. Bupropion selectively stimulated hopping/darting, while yohimbine lacked an action on female sexual behavior. Ventura�?�Aquino E and Fernández�?�Guasti A. The antidepressants fluoxetine and bupropion differentially affect proceptive behavior in the naturally cycling female rat. J Sex Med **;**:**�??**. (Source: The Journal of Sexual Medicine)

Pharmacotherapy Effects on Smoking Cessation Vary with Nicotine Metabolism Gene (CYP2A6)

ConclusionsNicotine replacement therapy is effective amongst individuals with fast, but not slow, CYP2A6�?�defined nicotine metabolism. The effect of bupropion on relapse likelihood is unlikely affected by nicotine metabolism as estimated from CYP2A6 genotype. The variation in treatment responses amongst smokers with genes may guide future personalized smoking cessation interventions. (Source: Addiction)

Effect of combined naltrexone and bupropion therapy on the brain�??s reactivity to food cues

Effect of combined naltrexone and bupropion therapy on the brain&#8217;s reactivity to food cues International Journal of Obesity advance online publication, September 10 2013. doi:10.1038/ijo.2013.145 Authors: G-J Wang, D Tomasi, N D Volkow, R Wang, F Telang, E C Caparelli & E Dunayevich (Source: International Journal of Obesity)

Efficacy of psychostimulant drugs for amphetamine abuse or dependence.

CONCLUSIONS: Results of this review do not support the use of psychostimulant medications at the tested doses as a replacement therapy for amphetamine abuse or dependence. Future research could change this conclusion, as the numbers of included studies and participants are limited and information on relevant outcomes, such as efficacy according to the severity of dependence or craving, is still missing. PMID: 23996457 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)

Randomized trial of nicotine replacement therapy (NRT), bupropion and NRT plus bupropion for smoking cessation: effectiveness in clinical practice

ConclusionThere is no difference in smoking cessation effectiveness among bupropion, nicotine replacement therapy and their combination when used with behavioural support in clinical practice. There is some evidence that bupropion is more beneficial than nicotine replacement therapy for smokers with a history of depression. (Source: Addiction)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Comparison of the behavioral effects of bupropion and psychostimulants.

Authors: Mori T, Shibasaki M, Ogawa Y, Hokazono M, Wang TC, Rahmadi M, Suzuki T Abstract Psychostimulant abuse has been a serious social problem worldwide for a long time. Bupropion, which is used as an antidepressant and to aid smoking cessation in the U.S., is considered to have psychostimulant-like activity. Although activation of the dopaminergic system induces several behavioral effects and bupropion can activate the dopaminergic system, the abuse potential and other behavioral effects of bupropion have not been fully investigated. Therefore, in this study we compared the behavioral effects of bupropion to those of psychostimulants in mice. Both methamphetamine and bupropion induced sensitization to locomotor activity, and cross-sensitized each other. Methamphetamine and bupro...

Tobacco cessation interventions for young people.

CONCLUSIONS: Complex approaches show promise, with some persistence of abstinence (30 days point prevalence abstinence or continuous abstinence at six months), especially those incorporating elements sensitive to stage of change and using motivational enhancement and CBT. Given the episodic nature of adolescent smoking, more data is needed on sustained quitting. There were few trials with evidence about pharmacological interventions (nicotine replacement and bupropion), and none demonstrated effectiveness for adolescent smokers. There is not yet sufficient evidence to recommend widespread implementation of any one model. There continues to be a need for well-designed adequately powered randomized controlled trials of interventions for this population of smokers. PMID: 23975659 [PubMe...

Exploration of 100 commonly used drugs and supplements on cognition in older adults.

CONCLUSIONS: Reported use of common medications is associated with cognitive performance in older adults, but studies are needed to investigate the mechanisms underlying these effects. PMID: 23954027 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)

Smoking cessation interventions for smokers with current or past depression.

CONCLUSIONS: Evidence suggests that adding a psychosocial mood management component to a standard smoking cessation intervention increases long-term cessation rates in smokers with both current and past depression when compared with the standard intervention alone. Pooled results from four trials suggest that use of bupropion may increase long-term cessation in smokers with past depression. There was no evidence found for the use of bupropion in smokers with current depression. There was not enough evidence to evaluate the effectiveness of the other antidepressants in smokers with current or past depression. There was also not enough evidence to evaluate the group of trials that investigated interventions without specific mood management components for depression, including NRT and psychos...

Relapse prevention interventions for smoking cessation.

CONCLUSIONS: At the moment, there is insufficient evidence to support the use of any specific behavioural intervention to help smokers who have successfully quit for a short time to avoid relapse. The verdict is strongest for interventions focused on identifying and resolving tempting situations, as most studies were concerned with these. Little research is available regarding other behavioural approaches.Extended treatment with varenicline may prevent relapse. Extended treatment with bupropion is unlikely to have a clinically important effect. Studies of extended treatment with nicotine replacement are needed. PMID: 23963584 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Exploration of 100 commonly used drugs and supplements on cognition in older adults

Conclusions: Reported use of common medications is associated with cognitive performance in older adults, but studies are needed to investigate the mechanisms underlying these effects. (Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association)

Understanding the role of cessation fatigue in the smoking cessation process

Abstract: Background: To understand the dynamic process of cessation fatigue (i.e., the tiredness of trying to quit smoking) with respect to its average trend, effect on relapse, time-varying relations with craving and negative affect, and differences among genders and treatment groups.Method: Randomized placebo-controlled clinical trial. Participants received either placebo, monotherapy (bupropion SR, nicotine patch, nicotine lozenge), or combined pharmacotherapy (bupropion SR+nicotine lozenge, nicotine patch+nicotine lozenge). Data were collected from 1504 daily smokers who were motivated to quit smoking. The participants completed baseline assessments and ecological momentary assessments for 2 weeks post-quit.Results: Cessation fatigue reduced the likelihood of 6-month post-quit abstine...

Influence of a Dopamine Pathway Additive Genetic Efficacy Score on Smoking Cessation: Results from Two Randomized Clinical Trials of Bupropion

ConclusionsA score based on functional polymorphisms relating to dopamine pathways appears to predict lapse to smoking following a quit attempt, and the association is mitigated in smokers using bupropion. (Source: Addiction)

Telephone counselling for smoking cessation.

CONCLUSIONS: Proactive telephone counselling aids smokers who seek help from quitlines. Telephone quitlines provide an important route of access to support for smokers, and call-back counselling enhances their usefulness. There is limited evidence about the optimal number of calls. Proactive telephone counselling also helps people who receive it in other settings. There is some evidence of a dose response; one or two brief calls are less likely to provide a measurable benefit. Three or more calls increase the chances of quitting compared to a minimal intervention such as providing standard self-help materials, or brief advice, or compared to pharmacotherapy alone. PMID: 23934971 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)

Effects of bupropion on cognitive performance during initial tobacco abstinence

We examined whether bupropion would attenuate abstinence-induced cognitive deficits on the first day of a brief quit attempt, when smokers are most likely to relapse.Methods: Smokers (N=24) with high quit interest were recruited for within-subjects cross-over test of bupropion vs placebo on ability to abstain during separate short-term practice quit smoking attempts. After introduction to working memory (N-back) and sustained attention (continuous performance task; CPT) tasks during the pre-quit smoking baseline, performance on these tasks was assessed after abstaining overnight (CO (Source: Drug and Alcohol Dependence)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Involvement of the monoaminergic system in the antidepressant-like activity of chromium chloride in the forced swim test.

Authors: Piotrowska A, Siwek A, Wolak M, Pochwat B, Szewczyk B, Opoka W, Poleszak E, Nowak G Abstract Bio-metal chromium(III) is a crucial microelement for the proper functioning of living organisms. Previous preclinical and clinical studies reported its potential antidepressant properties. The aim of the present study was to examine the effect of antidepressants and noradrenergic and dopaminergic receptor antagonists on chromium chloride (CrCl3) activity in the forced swim test (FST) in mice and rats. Imipramine (5 mg/kg), fluoxetine (5 mg/kg) and reboxetine (5 mg/kg) but not bupropion (1 mg/kg), administered jointly with CrCl3 at a dose of 6 mg/kg, reduced the immobility time in the FST in mice. The reduction of the immobility time induced by the active dose (12 mg/kg) of CrCl3 w...

[Antidepressants in epilepsy].

Authors: Castano-Monsalve B Abstract Depression is a common condition in patients with epilepsy that entails a deterioration of the quality of life of this population and that, therefore, requires appropriate treatment. The potential risk of antidepressants in relation to the seizure threshold is overestimated by many professionals, and this has an influence when it comes to making the decision to treat them. It sometimes means that the patients do not receive antidepressant drugs. In this regard, the aim of this review is to present the current state of the art in terms of the safety of antidepressants in patients with epilepsy. A search of the medical literature was conducted and, following its analysis, the most significant results are presented. Current information indicates th...

Randomized trial of NRT, bupropion, and NRT plus bupropion for smoking cessation: effectiveness in clinical practice

ConclusionThere is no difference in smoking cessation effectiveness among bupropion, nicotine replacement therapy (NRT) and their combination when used with behavioural support in clinical practice. There is some evidence that bupropion is more beneficial than NRT for smokers with a history of depression. (Source: Addiction)

Patterns of nicotinic receptor antagonism II: Cardiovascular effects in rats

Conclusions: The data indicate that the cardiovascular effects of nicotine and nicotine-like agents are mediated through receptor mechanisms that are distinct from those that mediate the central effects of nicotine. (Source: Drug and Alcohol Dependence)

Table of Contents

Abstract Use of valproate while pregnant increases child's autism risk SSRI exposure in utero linked to autism in children Pneumonia risk associated with typical versus atypical antipsychotics in nursing home residents Results conflict with FDA warning on high�?�dose citalopram Risk of Clostridium difficile infection with antidepressants? Editor's Commentary: DSM�?�5: Implications for psychopharmacology Benzodiazepine augmentation does not improve schizophrenia symptoms Bupropion effective for smoking treatment nonresponders Aripiprazole once�?�monthly assessed for schizophrenia d�?�Cycloserine augments CBT for social anxiety Clonidine improves gating deficits in patients with schizophrenia Psychostimulants for negative symptoms of schizophrenia FDA drug safety communication: Long�?�acting...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Bupropion Reduces the Inflammatory Response and Intestinal Injury Due to Ischemia-Reperfusion

Abstract: Intestinal ischemia-reperfusion (I/R) causes severe organ failure and intense inflammatory responses, which are mediated in part by the cytokine tumor necrosis factor-alpha (TNF-alpha). Bupropion is an antidepressant known to inhibit TNF-alpha production. We sought to examine the protective effects of bupropion on intestinal I/R injury in 15 male Sprague-Dawley rats that were randomized to sham surgery, 45 minutes of intestinal ischemia followed by 180 minutes reperfusion, or bupropion (100 mg/kg) before the intestinal I/R injury. To evaluate the systemic inflammatory response induced by intestinal I/R, we measured serum levels of TNF-alpha, interleukins-1 and -6, lipid peroxidation, and transaminases. Histologic analysis evaluated intestinal injury using the Chiu muscosal injury...

Clinical factors associated with weight loss outcomes after Roux-en-Y gastric bypass surgery.

CONCLUSIONS: Several variables previously associated with poorer weight loss after RYGB surgery including age, baseline BMI, and type 2 diabetes were replicated. Several others suggest possible clinical interventions for post-operative management of RYGB patients to improve weight loss outcomes. PMID: 23804287 [PubMed - as supplied by publisher] (Source: Obesity)

Bupropion Diversion and Misuse in the Correctional Facility

This article concludes that in the incarcerated population, bupropion is a medication with significant misuse and diversion potential. (Source: Journal of Correctional Health Care)

Sensitivity and Specificity of A Procedure for Early Human Screening of Novel Smoking Cessation Medications

ConclusionsAssessing days abstinent during 1 week of use of medication versus placebo in a cross�?�over design could be a useful early Phase 2 study design for discriminating between medications useful vs not useful in aiding smoking cessation. (Source: Addiction)

Effect of Repeated Wuniu Early Tea Administration on the CYP450 Activity Using a Cocktail Method

RA Xu, ZS Xu, GY Lin, LF Hu, XQ Wang, JS MaIndian Journal of Pharmaceutical Sciences 2013 75(1):94-98Wuniu early tea (Camellia sinensis) is an important beverage consumed in China. Up to date, a lot of methods for identifying and chemical analysing have been done. However, there is no report on the effects of Wuniu early tea on cytochrome P450 isozymes. Therefore, the present objective of our study was to evaluate the potential effects of Wuniu early tea on cytochrome P450 isozymes P2C9, P1A2, P2C19 and P2B6 in rats with a cocktail approach including, matching probe drugs of tolbutamide, phenacetin, omeprazole and bupropion. These four probe drugs were simultaneously administered to rats after repeated Wuniu early tea administration. The pharmacokinetics of the probes in the plasma was sim...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Potent inhibition of cytochrome P450 2B6 by sibutramine in human liver microsomes.

Authors: Bae SH, Kwon MJ, Choi EJ, Zheng YF, Yoon KD, Liu KH, Bae SK Abstract The present study was performed to evaluate the potency and specificity of sibutramine as an inhibitor of the activities of nine human CYP isoforms in liver microsomes. Using a cocktail assay, the effects of sibutramine on specific marker reactions of the nine CYP isoforms were measured in human liver microsomes. Sibutramine showed potent inhibition of CYP2B6-mediated bupropion 6-hydroxylation with an IC50 value of 1.61 μM and Ki value of 0.466 μM in a competitive manner at microsomal protein concentrations of 0.25 mg/ml; this was 3.49-fold more potent than the typical CYP2B6 inhibitor thio-TEPA (Ki = 1.59 μM). In addition, sibutramine slightly inhibited CYP2C19 activity (Ki = 16.6 μM, noncompetitive ...

SSRI-Related Modulation of Sexual Functioning is Predicted by Pre-treatment Resting State Functional Connectivity in Healthy Men.

Authors: Metzger CD, Walter M, Graf H, Abler B Abstract Sexual dysfunction related to treatment with selective serotonin reuptake inhibitors (SSRIs) is a common reason for discontinuation of otherwise effective antidepressant treatment regimens. Thus, identification of subjects at risk for this side effect remains a crucial challenge. After demonstrating task-related neural correlates of impaired sexual functioning under treatment with the SSRI paroxetine (Abler et al., 2011), we studied (1) if resting state brain function before treatment predicts subsequent development of treatment-related modulation of sexual function, and (2) which neural circuits relate to different aspects of the impairment. Effects of paroxetine and bupropion administration over 1 week on subjective sexual ...

Bupropion-induced hyponatremia

Abstract: Although hyponatremia has been reported with the use of various antidepressants, the association of hyponatremia with bupropion has been limited to two case reports. In this case report, we present the case of a 75-year-old man who developed hyponatremia with the use of bupropion, which improved with stoppage of bupropion. (Source: General Hospital Psychiatry)

Bupropion Drug Profile

Bupropion is an antidepressant, also sold as Zyban to help people quit smoking. The brand name of the antidepressant form is Wellbutrin. Here are important facts about bupropion HCl. (Source: About.com Bipolar Disorder)

Who receives prescriptions for smoking cessation medications? An association rule mining analysis using a large primary care database

Conclusions This novel approach identified sizeable and easily definable groups of patients who are systematically failing to receive support for smoking cessation in primary care. Association rule mining can be used to identify key numerically important groups at high or low risk of receiving treatment and hence potentially to improve healthcare delivery. (Source: Tobacco Control)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Wellbutrin / Zyban / Bupropion Side Effects

Bupropion is marketed under the brand names Wellbutrin (as an antidepressant) and Zyban (for smoking cessation). Common side effects include constipation, loss of appetite, dry mouth, and trembling or shaking. Other side effects may be more severe. (Source: About.com Bipolar Disorder)

Information about Some of the Newer &#039;Atypical&#039;...

Information about some of the newer 'atypical' antidepressants - Buspar buspirone Desyrel trazodone Effexor venlafaxine Remeron mirtazapine Serzone nefazodone Wellbutrin bupropion. (Source: About.com Mental Health)

Psychopharmacology and psychotherapy for the treatment of adults with ADHD-a systematic review of available meta-analyses.

CONCLUSION: The available meta-analytic literature does not cover questions of essential clinical relevance for adults with ADHD. PMID: 23739183 [PubMed - as supplied by publisher] (Source: CNS Spectrums)

Bupropion, methylphenidate, and 3,4-methylenedioxypyrovalerone antagonize methamphetamine-induced efflux of dopamine according to their potencies as dopamine uptake inhibitors: implications for the treatment of methamphetamine dependence

Conclusions: Bupropion and methylphenidate antagonize the effects of methamphetamine in vitro and may be potential candidates for the treatment of stimulant addiction. However, drugs that very potently antagonize the effect of methamphetamine are likely to also exhibit considerable abuse liability (MDPV�??>�??methylphenidate�??>�??bupropion). (Source: BMC Research Notes)

Characterizing the interaction between enantiomers of eight psychoactive drugs and highly sulfated-β-cyclodextrin by counter-current capillary electrophoresis.

Authors: Asensi-Bernardi L, Escuder-Gilabert L, Martín-Biosca Y, Sagrado S, Medina-Hernández MJ Abstract The estimation of apparent binding constants and limit mobilities of the complexes of the enantiomers that characterize the interaction of enantiomers with chiral selectors, in this case highly sulfated β-cyclodextrin, was approached using a simple and economic electrophoretic modality, the complete filling technique (CFT) in counter-current mode. The enantiomers of eight psychoactive drugs, four antihistamines (dimethindene, promethazine, orphenadrine and terfenadine) and four antidepressants (bupropion, fluoxetine, nomifensine and viloxazine) were separated for the first time for this cyclodextrin (CD). Estimations of thermodynamic and electrophoretic enantioselectivies wer...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Factors Associated with Discontinuation of Bupropion and Counseling Among African American Light Smokers in a Randomized Clinical Trial.

CONCLUSIONS: Bupropion and smoking cessation counseling are underutilized even when provided within the context of a randomized trial. Future research is needed to examine strategies for improving treatment utilization among African American smokers. Trial Registration No. NCT00666978 ( www.clinicaltrials.gov ). PMID: 23733379 [PubMed - as supplied by publisher] (Source: Annals of Behavioral Medicine)

Mechanism of Autoinduction of Methadone N-Demethylation in Human Hepatocytes.

CONCLUSIONS:Methadone caused concentration-dependent autoinduction of methadone N-demethylation in human hepatocytes, related to induction of CYP2B6 and CYP3A4 mRNA expression, protein expression, and catalytic activity. Induction was related to pregnane X receptor but not constitutive androstane receptor activation. These in vitro findings provide mechanistic insights into clinical autoinduction of methadone metabolism and clearance. PMID: 23733841 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)

BUPROPION HYDROCHLORIDEtablet, Film Coated [Sandoz Inc]

Updated Date: May 30, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Pharmacological means of reducing human drug dependence: A selective and narrative review of the clinical literature

Abstract Substance abuse or addictive disorder is a global problem. A greater understanding of the associated changes in brain pathophysiology support the notion that pharmacological treatments are part of the necessary treatment options. Craving is a core symptom of addictive disorder; it refers to a strong desire to use drugs again either to re�?�experience positive effects or to diminish negative experiences. Currently there are a number of medicines that are effective in the treatment of addictive disorders. These medications can either be for substitution (same pharmacological effect as the abused substance) or anticraving (decrease the craving of the abused substance). In this MEDLNE based review, we select specific compounds (naltrexone, acamprosate, topiramate, disulfiram, baclofen...

Behavioral characteristics and pharmacological manipulations of a nicotine-entrainable circadian oscillator.

Authors: Gillman AG, Leffel JK, Kosobud AE, Timberlake W Abstract Chronic daily administration of nicotine and other drugs of abuse has been found to entrain pre- and post-drug circadian locomotor activity episodes that oscillate on a 24-h schedule and persist for several days after administration ceases. This drug-entrainable oscillator system could conceivably lead to circadian rhythms of drug seeking and drug use in human drug addicts. The present study (1) characterizes the ability of daily nicotine administration to entrain circadian wheel-running activity episodes in rats across a range of doses, lighting schedules, and food access; and (2) tests whether pre- and post-nicotine episodes can be altered through pharmacological manipulations. Adult female rats were housed in whee...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Managing depression in patients with advanced heart failure awaiting transplantation.

CONCLUSION: Key considerations in antidepressant selection in the context of advanced HF include HF-related changes in drug pharmacokinetics that may affect initial dosing or dosage adjustment, possible drug interactions, adverse effects that may potentiate those induced by immunosuppressants added after transplantation, and tolerability issues. PMID: 23640347 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)

Characterization of the transporterB0AT3 (Slc6a17) in the rodent central nervous system

Conclusions: This suggests that the B0AT3 transporter have a role in regulation of monoaminergic as well as glutamatergic synapses. (Source: BMC Neuroscience - Latest articles)

WELLBUTRIN XL (Bupropion Hydrochloride) Tablet, Extended Release [BTA Pharmaceuticals]

Updated Date: May 3, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Adapting Smoking Cessation Treatment According to Initial Response to Precessation Nicotine Patch.

CONCLUSIONS It is possible to rescue a significant portion of smokers who would have failed to achieve abstinence if left on nicotine patch alone by identifying these smokers before their quit date and implementing adaptive changes in treatment. PMID: 23640009 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)

Intravenous lipid emulsion to reverse acute drug toxicity in pediatric patients.

CONCLUSIONS: There is an increasing interest in use of intravenous lipid emulsions to treat life-threatening toxicity from several lipophilic drugs in adults and children. Although most of the literature describes adult cases, intravenous lipid emulsion has been used in neonates and adolescents, with generally positive outcomes. Given the life-threatening, sometimes near-death situations in which an intravenous lipid emulsion is typically used after conventional resuscitation is unsuccessful and the dramatic positive response to this therapy in most published cases, its use likely will continue. Continued reporting of pediatric cases will guide the optimal use and safety profile of intravenous lipid emulsion for the emergent reversal of drug toxicity. PMID: 23613099 [PubMed - in proces...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Serotonergic drugs for depression and beyond.

Authors: Stahl SM, Lee-Zimmerman C, Cartwright S, Ann Morrissette D Abstract The current generation of antidepressant drugs acts predominantly by targeting the serotonin transporter (SERT). The original trend to do this selectively (e.g., with SSRIs or selective serotonin reuptake inhibitors) has given way to combining various additional pharmacologic mechanisms with SERT inhibition, including dual actions by single drugs (e.g., SNRIs or serotonin norepinephrine reuptake inhibitors), or by augmenting SSRIs with a second drug of a different mechanism (e.g., bupropion with dopamine and norepinephrine reuptake inhibition; trazodone with 5HT2A antagonism; mirtazapine with 5HT2A/5HT2C/5HT3/alpha2 antagonism; buspirone or some atypical antipsychotics with 5HT1A partial agonism; other aty...

Coping with urges to smoke: what is a clinician to do?

Authors: Modesto-Lowe V, Chmielewska A Abstract Cigarette smoking is a public-health problem associated with significant morbidity and mortality. Effective medications such as nicotine replacement therapy (NRT), bupropion, and varenicline can assistwith nicotine withdrawal and facilitate smoking cessation. In order to sustain abstinence, however, a smoker must also disrupt strong behavioral associations with smoking. Behavioral strategies complement pharmacotherapy by enhancing the smoker's motivation to quit and teaching quitting skills such as managing relapse triggers (e.g. negative emotions, urges to smoke). Despite these therapies, long-term cigarette abstinence rates are modest for each attempt to quit. However, many smokers who are persistent in their efforts eventually quit...

Teen girls less successful than boys at quitting meth in UCLA pilot research study

A UCLA-led study of adolescents receiving treatment for methamphetamine dependence has found that girls are more likely to continue using the drug during treatment than boys, suggesting that new approaches are needed for treating meth abuse among teen girls. &nbsp; Results from the study, conducted by the UCLA Center for Behavioral and Addiction Medicine and the community-based substance abuse treatment program Behavioral Health Services Inc., are published in the April edition of the Journal of Adolescent Health.&nbsp; &nbsp; "The greater severity of methamphetamine problems in adolescent girls compared to boys, combined with results of studies in adults that also found women to be more susceptible to methamphetamine than men, suggests that the gender differences in methamphetamine addict...

A Non-Epileptiform Event in the Course of rTMS: A Case for Close Physician Monitoring

We present the following case to demonstrate the importance of having physician supervision of patients undergoing repetitive transcranial magnetic stimulation (rTMS) treatments. The patient was a married 60-year-old male with a diagnosis of Major Depressive Disorder and Generalized Anxiety Disorder who had continuous symptoms of depression since the early 1980s despite receiving at least 7 adequate antidepressant treatments. The patient had several comorbid medical conditions. The patient did not have any previous history of seizure, stroke, an abnormal EEG, head injury, neurosurgical procedure, implanted devices, frequent headaches, or a neurologic illness. In addition, there was no family history of epilepsy. The patient's medications included bupropion XL 300 mg, diazepam 10 mg every...

Behavioral characterization of the 6-hydroxidopamine model of Parkinson's disease and pharmacological rescuing of non-motor deficits

Conclusions: Our results suggest that this model is a relevant tool to study the pathophysiology of motor and non-motor symptoms of PD. In addition, the present data shows that pharmacological interventions modulating dopaminergic transmission are also relevant to revert the non-motor behavioral deficits found in the disease. (Source: Molecular Neurodegeneration)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Genotoxicity of 2-bromo-3'-chloropropiophenone.

Authors: Meng F, Yan J, Li Y, Fu PP, Fossom LH, Sood RK, Mans DJ, Chu PI, Moore MM, Chen T Abstract Impurities are present in any drug substance or drug product. They can be process-related impurities that are not completely removed during purification or are formed due to the degradation of the drug substance over the product shelf-life. Unlike the drug substance, impurities generally do not have beneficial effects and may present a risk without associated benefit. Therefore, their amount should be minimized. 2-Bromo-3'-chloropropiophenone (BCP) is an impurity of bupropion, a second-generation antidepressant and a smoking cessation aid. The United States Pharmacopeia recommends an acceptable level for BCP that is not more than 0.1% of the bupropion. Because exposure to genotoxic i...

Pharmacotherapy of amphetamine�?�type stimulant dependence: An update

Conclusion.After over 20 years of efforts worldwide to develop a broadly effective medication for dependence on methamphetamine�?� or amphetamine�?�type stimulants, no candidate has emerged. This highlights the need for new compounds, consistent and stringent research methods, better integration between preclinical and clinical stages of medication development, and improved collaboration between government, industry and researchers. [Brensilver M, Heinzerling KG, Shoptaw S. Pharmacotherapy of amphetamine�?�type stimulant dependence: An update. Drug Alcohol Rev 2013] (Source: Drug and Alcohol Review)

BUPROPION HYDROCHLORIDE XL (Bupropion Hydrochloride) Tablet, Film Coated, Extended Release [Dispensing Solutions, Inc.]

Updated Date: Apr 9, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BUPROPION HYDROCHLORIDEtablet, Extended Release [Actavis South Atlantic LLC]

Updated Date: Apr 8, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Combination therapy with naltrexone and bupropion for obesity reduces total and visceral adiposity

The effects of combination naltrexone/bupropion therapy on body composition and visceral adipose tissue (VAT) mass were examined in a subset (n�??=�??107) of obese subjects from a Phase 2 trial that compared the efficacy and safety of placebo, naltrexone monotherapy, bupropion monotherapy or one of three naltrexone/bupropion dose combinations for 24�??weeks. Body composition data were obtained using dual�?�energy X�?�ray absorptiometry and computed tomography. Eighty subjects completed the substudy. Naltrexone/bupropion resulted in weight loss and a greater reduction in body fat (�??14.0�??~+mn~�??1.3%) than placebo (�??4.0�??~+mn~�??2.0%), naltrexone monotherapy (�??3.2�??~+mn~�??2.5%) and bupropion monotherapy (�??4.1�??~+mn~�??2.9%; all p�??&lt;�??0.01). Reduction in VAT mass was also greater with ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Increase in Work Productivity of Depressed Individuals With Improvement in Depressive Symptom Severity.

CONCLUSIONS Patients with clinically significant reductions in symptom severity during initial treatment were more likely than nonresponders to experience significant improvements in work productivity. In contrast, patients who achieved symptom remission in second-step treatment continued to have impairment at work. Patients who have demonstrated some degree of treatment resistance are more prone to persistent impairment in occupational productivity, implying a need for additional, possibly novel, treatments. PMID: 23558394 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)

Use of varenicline versus bupropion and risk of psychiatric adverse events

ConclusionsIn Denmark, the risk of psychiatric adverse events diagnosed during an emergency department visit or in�?�patient admission was not significantly higher with varenicline use compared with bupropion. (Source: Addiction)

High-performance liquid chromatographic enantioseparation of (RS)-bupropion using isothiocyanate-based chiral derivatizing reagents.

Authors: Bhushan R, Batra S Abstract A high-performance liquid chromatographic (HPLC) method for enantioseparation of bupropion was developed using two isothiocyanate-based chiral derivatizing reagents, (S)-1-(1-naphthyl) ethyl isothiocyanate, (S)-NEIT, and (R)-α-methyl benzyl isothiocyanate, (R)-MBIT. The diastereomers synthesized with (S)-NEIT were enantioseparated by reversed-phase HPLC using gradient elution with mobile phase containing water and acetonitrile, whereas diastereomers synthesized with (R)-MBIT were enantioseparated using triethyl amine phosphate buffer and methanol. Derivatization conditions were optimized and the method was validated for accuracy, precision and limit of detection. The limit of detection was found to be 0.040-0.043 µg/mL for each of the diastere...

Stop-Smoking Drugs Not Equal in Real Life (CME/CE)

(MedPage Today) -- Varenicline (Chantix) may hold some longer-term advantages for smoking cessation compared with bupropion (Zyban, others), according to a community-based trial. (Source: MedPage Today Psychiatry)

Treatment for Tobacco Dependence: Effect on Brain Nicotinic Acetylcholine Receptor Density

Authors: Arthur L Brody, Alexey G Mukhin, Stephanie Shulenberger, Michael S Mamoun, Maggie Kozman, Jonathan Phuong, Meaghan Neary, Trinh Luu & Mark A Mandelkern Keywords: Addiction & Substance Abuse; Biological Psychiatry; Bupropion; Cognitive-Behavioral Therapy; Imaging; Clinical or Preclinical; Nicotine; Nicotinic Acetylcholine Receptor; Psychiatry & Behavioral Sciences; Tobacco Dependence (Source: Neuropsychopharmacology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Antismoking and potential antipsychotic effects of varenicline in subjects with schizophrenia or schizoaffective disorder: A double-blind placebo and bupropion-controlled study

An increased rate of smoking among subjects with schizophrenia contributes to multiple negative health effects including higher rates of coronary heart disease, hypertension, respiratory disease and lung cancer than the general population (). Studies of nicotine cessation or reduction in schizophrenia have focused on a limited armamentarium of pharmacologic agents showing modest effects. Varenicline is a recent smoking cessation agent with potent partial agonism of the α4β2 and full agonism of the α7 nicotinic acetylcholine receptor; it may also activate the β4 nicotinic acetylcholine receptor (). Despite early reports of varenicline's exacerbation of psychiatric symptoms () leading to FDA issuance of black box warning, several recent studies provide evidence for its safety and effecti...

Pharmacotherapy for smoking cessation: Pharmacological principles and clinical practice

Abstract Strategies for assisting smoking cessation include behavioural counselling to enhance motivation and to support attempts to quit and pharmacological intervention to reduce nicotine reinforcement and withdrawal from nicotine. Three drugs are currently used as first�?�line pharmacotherapy for smoking cessation: nicotine replacement therapy, bupropion, and varenicline. Compared to placebo, the drug effect varies from 2.27 (95% CI 2.02�?�2.55) for varenicline, to 1.69 (95% CI 1.53�?�1.85) for bupropion, and to 1.60 (95% CI 1.53�?�1.68) for any form of nicotine replacement therapy. Despite some controversy regarding the safety of bupropion and varenicline, regulatory agencies consider these drugs as having a favourable benefit/risk profile. However, given the high rate of psychiatric c...

Combined antidepressants: clinical experience.

CONCLUSION: Adding or combining antidepressant medications has advantages for the speed of onset and maintaining the existing response. More rigorous clinical trials comparing combination therapy with monotherapy and for the development of rational treatment guidelines are required. PMID: 16307617 [PubMed - indexed for MEDLINE] (Source: Acta Psychiatrica Scandinavica Supplementum)

Severe DRESS Syndrome Managed With Therapeutic Plasma Exchange

We present a pediatric case of DRESS syndrome associated with either lamotrigine or bupropion, leading to multiorgan involvement and life-threatening complications of respiratory failure and cardiac arrest. After failing to improve with removal of these medications and administration of systemic corticosteroids, our patient showed dramatic, sustained clinical response to therapeutic plasma exchange. To our knowledge, this is the first reported case of therapeutic plasma exchange used for life-threatening DRESS syndrome in a pediatric patient. This case suggests needed research for this therapeutic option in life-threatening DRESS syndrome resistant to high-dose steroids. (Source: PEDIATRICS)

Use of Varenicline vs Bupropion and Risk of Psychiatric Adverse Events

ConclusionsIn Denmark, the risk of psychiatric adverse events diagnosed during an emergency department visit or inpatient admission is not significantly higher with varenicline use compared with bupropion. (Source: Addiction)

Intranasal bupropion abuse: case report.

Authors: Yoon G, Westermeyer J PMID: 23414507 [PubMed - in process] (Source: American Journal on Addictions)

An Unusual Case of Chronic Diarrhea

Question: An 80-year-old man with a history of Henoch�??Schonlein purpura at the age of 59 requiring partial jejunal resection, coronary artery disease, chronic kidney disease, gout, gastroesophageal reflux disease, and prior cholecystectomy was admitted for 2 weeks of guaiac-positive watery brown diarrhea and dehydration. Medications included aspirin 81 mg/d, clopidogrel, aldactazide, furosemide, hydralazine, isosorbide mononitrate, metoprolol, simvastatin, lansoprazole, allopurinol, trazodone, and tamsulosin. He had switched from citalopram to bupropion 2 weeks prior. He was afebrile and hemodynamically stable. His abdomen was distended and tympanitic, with normal bowel sounds and tenderness to palpation over the epigastrium and periumbilical area, but no peritoneal signs. Laboratory eva...

pH-gradient PAMPA-based in vitro model assay for drug-induced phospholipidosis in early stage of drug discovery.

Authors: Balogh GT, Müller J, Könczöl A Abstract In the present study we validated a widely used, high-throughput in vitro permeability model (PAMPA) to be used at the early stage of drug discovery for the phospholipidosis (PLD) prediction of drug-like compounds. Regarding the mechanism of action of PLD, our pH-gradient PAMPA system is the first noncell based model to mimic one-way transport of cationic amphiphilic drugs (CADs) from cytosol to the lysosome. Moreover, due to the fact that PLD can mainly occur in lung, liver, brain, kidney and heart, we have used similar commercially available original tissue-derived lipid fractions (heart, liver, brain), and in the case mimicking membrane of kidney and lung tissue we prepared tissue-mimetic artificial lipid mixtures in house. Met...

Hypokalemia Secondary to Bupropion Sustained Release Overdose

Journal of Child and Adolescent Psychopharmacology Feb 2013, Vol. 23, No. 1: 57-60. (Source: Journal of Child and Adolescent Psychopharmacology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

BUDEPRION (Bupropion Hydrochloride) Tablet, Extended Release [Bryant Ranch Prepack]

Updated Date: Feb 8, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BUPROPION HYDROCHLORIDEtablet, Film Coated, Extended Release [Preferred Pharmaceuticals, Inc]

Updated Date: Feb 6, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Reward responsiveness and fatigue in multiple sclerosis

Discussion: Reward responsiveness was linked with MS-related fatigue and might represent one of its key cognitive underpinnings. Our results suggest that evaluation of reward responsiveness could provide useful information to guide individualized therapy of MS-related fatigue. (Source: Multiple Sclerosis)

Characterization of marmoset CYP2B6: cDNA cloning, protein expression and enzymatic functions.

Authors: Mayumi K, Hanioka N, Masuda K, Koeda A, Naito S, Miyata A, Narimatsu S Abstract The common marmoset is a promising species for evaluating the safety of drug candidates. To further understand the capacity for drug metabolism in marmosets, a cDNA encoding a CYP2B enzyme was cloned from the total RNA fraction of marmoset liver by 3'- and 5'-RACE methods. Nucleotide and deduced amino acid sequences showed 90.8 and 86.2% identity, respectively, with human CYP2B6. The marmoset CYP2B6 (marCYP2B6) protein was expressed in insect cells, and its enzymatic properties were compared with those of human (humCYP2B6) and cynomolgus monkey (cynCYP2B6) orthologs in liver and insect cell microsomes. Enzymatic functions were examined for the oxidation of 7-ethoxy-4-(trifluoromethyl)coumarin (...

Choosing a Generic AntidepressantChoosing a Generic Antidepressant

With one generic bupropion formulation recently withdrawn, how can clinicians best select from among the remaining options? FDA on Medscape (Source: Medscape Today Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Novel CYP2B6 Enzyme Variants in a Rwandese Population: Functional Characterization and Assessment of in silico Prediction Tools

Abstract Cytochrome P450 CYP2B6 is a highly polymorphic enzyme that metabolizes numerous drugs, pesticides, and environmental toxins. Sequence analysis of a Rwandese population identified eight functionally uncharacterized non�?�synonymous variants c.329G&gt;T (p.G110V), c.341T&gt;C (p.I114T), c.444G&gt;T (p.E148D), c.548T&gt;G (p.V183G), c.637T&gt;C (p.F213L), c.758G&gt;A (p.R253H), c.835G&gt;C (p.A279P), c.1459C&gt;A (p.R487S) and five novel alleles termed CYP2B6*33 to CYP2B6*37 were assigned. Recombinant expression in COS�?�1 cells and functional characterization using the antidepressant bupropion and the antiretroviral efavirenz as substrates demonstrated complete or almost complete loss�?�of�?�function for variants p.G110V, p.I114T, p.V183G, and p.F213L, while p.E148D, p.R253H, p.A279...

Antidepressant link to heart changes confirmed

Conclusion This study shows a link between three antidepressants (two SSRIs and one tricyclic) and prolonged QT interval (a risk factor for rare but serious heart rhythm problems). The study did not assess the risk of these heart rhythm problems directly (which is difficult to measure because of their rarity). The researchers point out that the recent FDA warning over the risks of citalopram was based on its association with prolonged QT interval only, and �??in spite of the epidemiological data showing no difference in risk for arrhythmia [heart rhythm abnormality]�?�. The researchers say that certain SSRIs were not significantly associated with risk of prolonged QT interval, and that these medications may be preferable treatment options for people with other cardiac risk factors. Althoug...

Bupropion for Smoking Cessation in Patients Hospitalized With Acute Myocardial Infarction: A Randomized, Placebo-Controlled Trial

Conclusions: Two-thirds of patients return to smoking by 12 months after AMI. Bupropion is well tolerated and seems to be safe to use in the immediate post-AMI period. However, bupropion is not effective for smoking cessation in patients post-AMI. (Zyban as an Effective Smoking Cessation Aid for Patients Following an Acute Coronary Syndrome: The ZESCA Trial; NCT00689611) (Source: Journal of the American College of Cardiology)

Smoking-Cessation Drug Not Effective in the Post-AMI SettingSmoking-Cessation Drug Not Effective in the Post-AMI Setting

Although safe and well tolerated in the immediate post-AMI period, treatment with bupropion failed to halt cigarette smoking, as more than two-thirds returned to smoking by 12 months after their AMI. Heartwire (Source: Medscape Today Headlines)

BUDEPRION SR (Bupropion Hydrochloride) Tablet, Extended Release [Bryant Ranch Prepack]

Updated Date: Jan 29, 2013 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Bupropion for Smoking Cessation in Patients Hospitalized With Acute Myocardial Infarction A Randomized, Placebo-Controlled Trial

ConclusionsTwo-thirds of patients return to smoking by 12 months after AMI. Bupropion is well tolerated and seems to be safe to use in the immediate post-AMI period. However, bupropion is not effective for smoking cessation in patients post-AMI. (Zyban as an Effective Smoking Cessation Aid for Patients Following an Acute Coronary Syndrome: The ZESCA Trial; NCT00689611) (Source: Journal of the American College of Cardiology: Cardiovascular Interventions)

Smoking-cessation drug bupropion not effective in the post-AMI setting

Although safe and well tolerated in the immediate post-AMI period, treatment with bupropion failed to halt cigarette smoking, as more than two-thirds returned to smoking by 12 months after their AMI. (Source: theHeart.org)

Stop-Smoking Drug No Help After MI (CME/CE)

(MedPage Today) -- Taking bupropion (Zyban) right after a heart attack won't help smokers quit, researchers found. (Source: MedPage Today Cardiovascular)

Investigating the roles of different monoamine transmitters and impulse control using the 5-choice serial reaction time task

Previous studies have shown that drugs which block the reuptake of catecholamine neurotransmitters improve impulse control in diseases such as attention deficit hyperactivity disorder (ADHD). Serotonin-specific reuptake inhibitors (SSRI) lack efficacy in ADHD and have been linked to increased suicide risk. The present study investigated drugs with affinity for one or more of the monoamine reuptake transporters using the 5-choice serial reaction time task, a model of attention and impulsivity in rodents. We also tested the effects of the alpha2-adreoceptor antagonist, idazoxan and novel antidepressant, agomelatine, which both increase cortical noradrenaline concentrations through non-reuptake mechanisms. Improvements in impulse control were observed with venlafaxine, a serotonin and noradre...

Bupropion: Visual hallucinations: case report

(Source: Reactions)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Pilot Randomized Trial of Bupropion for Adolescent Methamphetamine Abuse/Dependence

Conclusions: Results do not support the feasibility of additional trials of bupropion for adolescent methamphetamine abuse/dependence. Future studies should investigate the influence of gender on adolescent methamphetamine abuse and treatment outcomes. (Source: Journal of Adolescent Health)

Table of Contents

Abstract Discontinuing Risperidone Linked to Agitation in Alzheimer's Prenatal Antidepressant Exposure Not Linked to Intellectual, Behavioral Effects Rhabdomyolysis Linked to Pregabalin and Simvastatin Bipolar Patients at Higher Risk for Adverse Pregnancy Outcomes FDA: Benefits of New Obesity Drugs Greater than Risks Study Examines Risk for Cardiovascular Events of Varenicline vs. Bupropion Scopolamine Augmentation for Moderate to Severe Depression N�?�acetylcysteine as an Add�?�On Treatment for OCD Memantine Augmentation for Moderate to Severe OCD Discontinuation Paxil Labeling Revision (Source: The Brown University Psychopharmacology Update)

Bupropion/gabapentin overdose: Burst suppression, seizures and cardiovascular disorders: case report

(Source: Reactions)

Predictors of success in smoking cessation among Italian adults motivated to quit

In conclusion, we found that a steady attendance of the cognitive behavioral program, as well as the addition of pharmacologic interventions to counseling, remarkably increased the probability of the smoking cessation behavior to be determined. Nevertheless, FTQ was a valid measure in predicting the smoking cessation, and women revealed to be more likely to keep the smoking behavior, as well as subjects who declared an age of onset less than 17years. (Source: Journal of Substance Abuse Treatment)

Bupropion Med Profile

Bupropion is an antidepressant, also sold as Zyban to help people quit smoking. The brand name of the antidepressant form is Wellbutrin. Here are important facts about bupropion HCl. (Source: About.com Bipolar Disorder)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Taking Bupropion, Wellbutrin or Zyban? Facts You Need

Here are important things you should know if you're taking one of these three drugs in any form. For example, people with a history of anorexia or bulimia shouldn't take ...Read Full Post (Source: About.com Bipolar Disorder)

Effects of amylin and bupropion/naltrexone on food intake and body weight are interactive in rodent models.

Authors: Clapper JR, Athanacio J, Wittmer C, Griffin PS, D'Souza L, Parkes DG, Roth JD Abstract Antagonism of opioid systems (e.g., with naltrexone) has been explored as an anti-obesity strategy, and is particularly effective when co-administered with dual inhibitors of dopamine and norepinephrine reuptake (e.g., bupropion). Previously, we demonstrated that amylin enhances the food intake lowering and weight loss effects of neurohormonal (e.g., leptin, cholecystokinin, melanocortins) and small molecule (e.g., phentermine, sibutramine) agents. Here, we sought to characterize the interaction of amylin with naltrexone/bupropion on energy balance. Wild-type and amylin knockout mice were similarly responsive to the food intake lowering effects of either naltrexone (1mg/kg, subcutaneous)...

Pharmacotherapy Considerations in Patients with HIV and Psychiatric Disorders: Focus on Antidepressants and Antipsychotics.

CONCLUSIONS: Larger controlled studies are needed to validate the current findings as well as expand knowledge for non-SSRI antidepressants and second-generation antipsychotics for use in HIV-infected patients. PMID: 23341158 [PubMed - in process] (Source: The Annals of Pharmacotherapy)

Cardiovascular effects of pharmacologic therapies for smoking cessation

Abstract: Tobacco dependence is a potent risk factor for cardiovascular (CV) diseases and, despite known harms of smoking and benefits associated with smoking cessation, approximately 20% of the adult population with CV diseases or hypertension continue to smoke. Extensive research has demonstrated that nicotine replacement, varenicline, and bupropion sustained-release are superior to placebo for short- and intermediate-term smoking cessation. Because of their mechanisms of action, some smoking cessation therapies have been thought to have the potential to increase CV risk, particularly if the pharmacotherapies are taken while individuals are still smoking. Hence, we have analytically reviewed the literature describing the CV effects of therapies for smoking cessation, particularly as th...

Increased oxidative stress in patients with depression and its relationship to treatment

In conclusion, oxidative stress is increased in patients with depression. However, although treatment with either bupropion or sertraline reduces the symptoms of depression, it may increase F2 isoprostane excretion. These results suggest that alternative mechanisms, beyond oxidative stress, may be involved in the development of depression and subsequent responses to treatment. (Source: Psychiatry Research)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2013

Yatham LN, Kennedy SH, Parikh SV, Schaffer A, Beaulieu S, Alda M, O�??Donovan C, MacQueen G, McIntyre RS, Sharma V, Ravindran A, Young LT, Milev R, Bond DJ, Frey BN, Goldstein BI, Lafer B, Birmaher B, Ha K, Nolen WA, Berk M. �?�Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2013. �?�Bipolar Disord 2012: 00: 000�??000. © 2012 John Wiley & Sons A/S.Published by Blackwell Publishing Ltd. The Canadian Network for Mood and Anxiety Treatments published guidelines for the management of bipolar disorder in 2005, with updates in 2007 and 2009. This third update, in conjunction with the International Society for Bipolar Disorder...

BUPROPION HYDROCHLORIDEtablet, Film Coated, Extended Release [Mylan Institutional Inc.]

Updated Date: Dec 12, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BUPROPION HYDROCHLORIDEtablet, Extended Release [Sandoz Inc]

Updated Date: Dec 12, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Primary Care-Relevant Interventions for Tobacco Use Prevention and Cessation in Children and Adolescents: A Systematic Evidence Review for the U.S. Preventive Services Task Force.

CONCLUSION: Primary care-relevant interventions may prevent smoking initiation over 12 months in children and adolescents. PRIMARY FUNDING SOURCE: Agency for Healthcare Research and Quality. PMID: 23229625 [PubMed - as supplied by publisher] (Source: Annals of Internal Medicine)

Does early-onset chronic or recurrent major depression impact outcomes with antidepressant medications? A CO-MED Trial Report.

CONCLUSIONS: Although early-onset chronic/recurrent MDD is associated with a more severe clinical picture, it does not seem to be useful for predicting differential treatment response to antidepressant medication. Clinicians should remain alert to an increased risk of suicidality in this population. PMID: 23228340 [PubMed - as supplied by publisher] (Source: Psychological Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

The Pharmacist "Toolbox" for Smoking Cessation: A Review of Methods, Medicines, and Novel Means to Help Patients Along the Path of Smoking Reduction to Smoking Cessation

Annually there are 500 000 preventable deaths in the United States caused by smoking; as health care professionals, pharmacists have a unique opportunity to advise, assess, and assist patients to quit smoking. This review article provides pharmacists with a "toolbox" containing an overview of pharmacologic and nonpharmacologic methods for smoking cessation. Currently approved over-the-counter (OTC) and prescription medications (nicotine replacement therapy, varenicline, and bupropion) are summarized, and nonpharmacologic therapies discussed include cognitive therapy and hypnosis. In addition to traditional therapies some potential approaches to smoking cessation are addressed, including nicotine immunizations and electronic cigarettes. (Source: Journal of Pharmacy Practice)

WELLBUTRIN (Bupropion Hydrochloride) Tablet, Film Coated [GlaxoSmithKline LLC]

Updated Date: Dec 5, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

WELLBUTRIN SR (Bupropion Hydrochloride) Tablet, Film Coated [GlaxoSmithKline LLC]

Updated Date: Dec 4, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BUPROPION HYDROCHLORIDEtablet, Film Coated, Extended Release [Global Pharmaceuticals, Division Of Impax Laboratories Inc.]

Updated Date: Dec 4, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Effect of TSHAC on Human Cytochrome P450 Activity, and Transport Mediated by P-Glycoprotein.

Authors: Im Y, Kim YW, Song IS, Joo J, Shin JH, Wu Z, Lee HS, Park KH, Liu KH Abstract TSAHC [4'-(p-toluenesulfonylamido)-4-hydroxychalcone] is a promising antitumorigenic chalcone compound, especially against TM4SF5 (four-transmembrane L6 family member 5)-mediated hepatocarcinoma. We evaluated the potential of TSAHC to inhibit the catalytic activities of nine cytochrome P450 isoforms and of P-glycoprotein (Pgp). The abilities of TSAHC to inhibit phenacetin Odeethylation (CYP1A2), coumarin 6-hydroxylation (CYP2A6), bupropion hydroxylation (CYP2B6), amodiaquine Ndeethylation (CYP2C8), diclofenac 4-hydroxylation (CYP2C9), omeprazole 5-hydroxylation (CYP2C19), dextromethorphan O-demethylation (CYP2D6), chlorzoxazone 6-hydroxylation (CYP2E1), and midazolam 1'-hydroxylation (CYP3A) were...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Treatment of depression in cardiovascular disease

ConclusionsThere is considerable evidence from randomized controlled clinical trials that antidepressants, especially SSRIs, are safe in the treatment of major depression in patients with CVD. Although efficacy has been demonstrated in some, but not all, trials for both antidepressants and certain psychotherapies, large, well�?�powered trials are urgently needed. There are virtually no data available on predictors of antidepressant response in depressed patients with CVD. Whether successful treatment of depression is associated with a reduction in cardiac morbidity and mortality remains unknown. (Source: Depression and Anxiety)

Nicotine replacement therapy for smoking cessation.

CONCLUSIONS: All of the commercially available forms of NRT (gum, transdermal patch, nasal spray, inhaler and sublingual tablets/lozenges) can help people who make a quit attempt to increase their chances of successfully stopping smoking. NRTs increase the rate of quitting by 50 to 70%, regardless of setting. The effectiveness of NRT appears to be largely independent of the intensity of additional support provided to the individual. Provision of more intense levels of support, although beneficial in facilitating the likelihood of quitting, is not essential to the success of NRT. PMID: 23152200 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Nicotine receptor partial agonists for smoking cessation.

CONCLUSIONS: Cytisine increases the chances of quitting, although absolute quit rates were modest in two recent trials. Varenicline at standard dose increased the chances of successful long-term smoking cessation between two- and threefold compared with pharmacologically unassisted quit attempts. Lower dose regimens also conferred benefits for cessation, while reducing the incidence of adverse events. More participants quit successfully with varenicline than with bupropion. Two open-label trials of varenicline versus NRT suggested a modest benefit of varenicline but confidence intervals did not rule out equivalence. Limited evidence suggests that varenicline may have a role to play in relapse prevention. The main adverse effect of varenicline is nausea, but mostly at mild to moderate level...

CYP2B6 and Bupropion's Smoking-Cessation Pharmacology: The Role of Hydroxybupropion.

Authors: Zhu AZ, Cox LS, Nollen N, Faseru B, Okuyemi KS, Ahluwalia JS, Benowitz NL, Tyndale RF Abstract Bupropion is indicated to promote smoking cessation. Animal studies suggest that the pharmacologic activity of bupropion can be mediated by its major metabolite, hydroxybupropion. We measured plasma bupropion and its metabolite levels in a double-blind, placebo controlled, randomized smoking-cessation trial. Among the treatment-adherent individuals, higher hydroxybupropion concentrations (per μg/ml) resulted in better smoking-cessation outcomes (week 3, 7, and 26 odds ratio (OR) = 2.82, 2.96, and 2.37, respectively, P = 0.005-0.040); this was not observed with bupropion levels (OR = 1.00-1.03, P = 0.59-0.90). Genetic variation in CYP2B6, the enzyme that metabolizes bupropion to ...

BUPROPION HYDROCHLORIDE (XL) (Bupropion Hydrochloride) Tablet, Film Coated, Extended Release [Wockhardt Limited]

Updated Date: Nov 26, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

BUPROPION HYDROCHLORIDE (XL) (Bupropion Hydrochloride) Tablet, Film Coated, Extended Release [Wockhardt USA LLC.]

Updated Date: Nov 26, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BUPROPION HYDROCHLORIDE XL (Bupropion Hydrochloride) Tablet, Film Coated, Extended Release [Lake Erie Medical DBA Quality Care Products LLC]

Updated Date: Nov 16, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Assessment of cytochrome P450 (1A2, 2B6, 2C9 and 3A4) induction in cryopreserved human hepatocytes cultured in 48-well plates using the cocktail strategy.

Authors: Gerin B, Dell'aiera S, Richert L, Smith S, Chanteux H Abstract 1.�??A fast, straightforward and cost-effective assay was validated for the assessment of CYP induction in cryopreserved human hepatocytes cultured in 48-well plates. The cocktail strategy (in situ incubation) was used to assess the induction of CYP1A2, CYP2B6, CYP2C9 and CYP3A4 by using the recommended probe substrate, i.e. phenacetin, bupropion, diclofenac and midazolam, respectively. 2.�??Cryopreserved human hepatocytes were treated for 72�??h with prototypical reference inducers, β-naphthoflavone (25 µM), phenobarbital (500 µM) and rifampicin (10 µM) as positive controls for CYP induction. The use of a cocktail strategy has been validated and compared to the classical approach (single incubation). The ...

BUPROPION HYDROCHLORIDEtablet, Film Coated, Extended Release [PD-Rx Pharmaceuticals, Inc.]

Updated Date: Nov 13, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Antidepressant therapy in epilepsy �?? can treating the comorbidities affect the underlying disorder?

Summary There is a high incidence of psychiatric comorbidity in people with epilepsy (PWE), particularly depression. The manifold adverse consequences of comorbid depression have been more clearly mapped in recent years. Accordingly, considerable efforts have been made to improve detection and diagnosis, with the result that many PWE are treated with antidepressant drugs, medications with the potential to influence both epilepsy and depression. Exposure to older generations of antidepressants (notably tricyclic antidepressants and bupropion) can increase seizure frequency. However, a growing body of evidence suggests that newer (�??second generation�??) antidepressants, such as selective serotonin reuptake inhibitors or serotonin�?�noradrenaline reuptake inhibitors, have markedly less effe...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Use of varenicline for smoking cessation and risk of serious cardiovascular events: nationwide cohort study

Source: BMJ Area: News Against the background of increasing worldwide use of varenicline, postmarketing surveillance and other research have identified and investigated several safety concerns, including psychiatric effects, suicide and suicidal ideation, and cardiovascular effects. However a meta-analysis of RCTs has reported no significantly increased risk of cardiovascular events in patients taking varenicline compared with those taking placebo. The debate about a causal effect thus continues. &#160; A paper in the BMJ further explores the association between use of varenicline and the occurrence of serious cardiovascular events, including myocardial infarction, unstable angina, ischaemic stroke, and death from cardiovascular disease. &#160; It reports the findings of a Danish ...

BUPROPION HYDROCHLORIDEtablet, Film Coated [Bryant Ranch Prepack]

Updated Date: Nov 6, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Combined pharmacotherapy and behavioural interventions for smoking cessation

Source: Cochrane Area: Evidence &#62; Disease Focused Reviews Background Both behavioural support (including brief advice and counselling) and pharmacotherapies (including nicotine replacement therapy (NRT), varenicline and bupropion) are effective in helping people to stop smoking. Combining both treatment approaches is recommended where possible, but the size of the treatment effect with different combinations and in different settings and populations is unclear. &#160; Objectives To assess the effect of combining behavioural support and medication to aid smoking cessation, compared to a minimal intervention or usual care, and to identify whether there are different effects depending on characteristics of the treatment setting, intervention, population treated, or take-up of treatm...

The Antidepressant Drug Best for Sex

Compared with the SSRIs, Wellbutrin treats depression just as well but causes far fewer sexual side effects.read more (Source: Psychology Today Depression Center)

QTC Prolongation and Torsades in Bupropion Overdoses Presenting to United States Emergency Departments

Bupropion is an atypical antidepressant commonly used for depression and smoking cessation. It is structurally dissimilar to other antidepressants and is an inhibitor of norepinephrine and dopamine uptake. It is associated with QTc prolongation in therapeutic use and in overdose. There are limited data assessing QTc prolongation and torsades de points (TDP) in cases of overdose. The purpose of this study is to assess the incidence of QTc prolongation and the development of TDP in cases of bupropion overdose presenting to Emergency Departments (EDs). (Source: The Journal of Emergency Medicine)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Combined pharmacotherapy and behavioural interventions for smoking cessation.

CONCLUSIONS: Interventions that combine pharmacotherapy and behavioural support increase smoking cessation success compared to a minimal intervention or usual care. Further trials would be unlikely to change this conclusion. We did not find strong evidence from indirect comparisons that offering more intensive behavioural support was associated with larger treatment effects but this could be because intensive interventions are less likely to be delivered in full. PMID: 23076944 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

Antidepressants for depression in stage 3-5 chronic kidney disease: a systematic review of pharmacokinetics, efficacy and safety with recommendations by European Renal Best Practice (ERBP)

Conclusions Dose reduction in CKD3-5 is necessary for selegiline, amitriptylinoxide, venlafaxine, desvenlafaxine, milnacipran, bupropion, reboxetine and tianeptine. The evidence on effectiveness of antidepressants versus placebo in patients with CKD3-5, and with the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)-defined depression is insufficient, and in view of the high prevalence, a well-designed RCT is greatly needed. (Source: Nephrology Dialysis Transplantation)

Dilated and Unreactive Pupils and Burst-Suppression on Electroencephalography due to Buproprion Overdose

We report a case of a 29-year-old female thought to be brain dead based on initial physical examination and EEG findings of burst-suppression, who was later found to have supratherapeutic serum levels of bupropion. This is the second documented case of burst-suppression pattern on EEG in a patient who overdosed on bupropion. We propose that burst-suppression in the setting of bupropion toxicity may revert with drug clearance. (Source: Journal of Intensive Care Medicine)

Statistics on NHS Stop Smoking Services: England, April 2012 to June 2012

Source: NHS Information Centre Area: News This quarterly report presents provisional results from the monitoring of the NHS Stop Smoking Services (NHS SSS) in England during the period 1 April 2012 to 30 June 2012. &#160; The reports noted some of the following findings: &#160; .&#160;176,945 people set a quit date through NHS Stop Smoking Services. .&#160;At the 4 week follow-up, 86,341 people had successfully quit (based on self-report), 49% of those setting a quit date. .&#160;The majority of those setting a quit date received nicotine replacement therapy (NRT) only (64%). A further 26% received varenicline only, 1% received bupropion only, 2% received both NRT and varenicline and less than 1% received both NRT and bupropion. .&#160;Of those who used varenicline only, 60%...

BUPROPION HYDROCHLORIDEtablet, Film Coated [Bryant Ranch Prepack]

Updated Date: Oct 17, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Fluoxetine and sertraline may be associated with lower risk of suicide death than paroxetine in adults with depression

Question Question: What is the risk of suicide death for people with depression on antidepressants? People: 502&nbsp;179 adults in the Veterans Affairs (VA) Health System with depression (identified using implantable cardioverter defibrillator (ICD) coding), who started taking any of the most commonly used antidepressants between April 1999 and September 2004. A new antidepressant start (index date) was defined as filling of a prescription for any of the antidepressants after at least 6&nbsp;months with no observed antidepressant prescription fills. Exclusion criteria: diagnosis of bipolar I, schizophrenia or schizoaffective disorder. Setting: Department of VA Health System, USA; 1999&ndash;2004. Risk factors: New start on one of the antidepressants (27.0% started sertraline, 26.1% citalop...

Why Quitting Smoking Without Help Is So Hard

Quitting smoking is hard, and although most people quit alone, many need help. Focusing on motivation and other personality factors might be key.read more (Source: Psychology Today Addiction Center)

BUPROPION HYDROCHLORIDEtablet, Film Coated, Extended Release [Mylan Pharmaceuticals Inc.]

Updated Date: Oct 15, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Therapeutic equivalence of bupropion generics in question

(Source: Reactions)

BUPROPION HYDROCHLORIDE XL (Bupropion Hydrochloride) Tablet, Film Coated, Extended Release [Lake Erie Medical DBA Quality Care Products LLC]

Updated Date: Oct 12, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Antidepressant-like effect of creatine in mice involves dopaminergic activation

This study investigated the effect of creatine (p.o.) in the tail suspension test, a predictive test of antidepressant activity. Creatine reduced the immobility time in the tail suspension test (0.1&ndash;1000 mg/kg, male and female mice), without affecting locomotor activity. Furthermore, the involvement of the dopaminergic system in creatine-induced antidepressant-like effect in male mice in the tail suspension test was investigated. The anti-immobility effect of creatine (1 mg/kg) was prevented by the pre-treatment of mice with haloperidol (0.2 mg/kg, intraperitoneal (i.p.) route, non-selective dopamine receptor antagonist), (R)-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (SCH23390; 0.05 mg/kg, subcutaneous (s.c.) route, dopamine D1 recepto...

Bupropion pre-treatment of endotoxin-induced depressive symptoms.

Authors: Dellagioia N, Devine L, Pittman B, Hannestad J Abstract Increased levels of inflammatory cytokines may play a role in depression. Depressive symptoms can be induced in humans with administration of low-dose lipopolysaccharide (LPS; endotoxin), which activates the innate immune system and causes release of inflammatory cytokines. We previously found that pre-treatment with the serotonin reuptake inhibitor citalopram reduced LPS-induced fatigue and anhedonia. This is a follow-up study to determine whether LPS-induced symptoms could be reduced by pre-treatment with bupropion, a norepinephrine and dopamine reuptake inhibitor. In this double-blind, randomized, placebo-controlled, cross-over study, 10 healthy subjects received intravenous LPS (0.8 ng/kg) after oral pre-treatment...

Once-Daily Antidepressant Now Available in the USOnce-Daily Antidepressant Now Available in the US

Forfivo XL, a new extended-release formulation of bupropion hydrochloride, is now available in the US for the treatment of major depressive disorder. Medscape Medical News (Source: Medscape Today Headlines)

BUPROPION HYDROCHLORIDE XL (Bupropion Hydrochloride) Tablet, Film Coated, Extended Release [Bryant Ranch Prepack]

Updated Date: Oct 9, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BUPROPION HYDROCHLORIDEtablet, Film Coated, Extended Release [PD-Rx Pharmaceuticals, Inc.]

Updated Date: Oct 9, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

BUPROPION HYDROCHLORIDEtablet, Film Coated, Extended Release [Bryant Ranch Prepack]

Updated Date: Oct 9, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Psychological and physiological effects of bupropion compared to methylphenidate after prolonged administration in healthy volunteers (NCT00285155)

Conclusion&nbsp;&nbsp;Although it may not share all the properties of stimulant drugs, the effect profile of bupropion presents a number of similarities with that of methylphenidate over a 2-week treatment period. Content Type Journal ArticleCategory Clinical TrialPages 1-9DOI 10.1007/s00228-012-1418-zAuthors Hugues Chevassus, CHRU Montpellier, Centre d�??Investigation Clinique, Montpellier, FranceAnne Farret, CHRU Montpellier, Centre d�??Investigation Clinique, Montpellier, FranceJean-Pierre Gagnol, CHRU Montpellier, Centre d�??Investigation Clinique, Montpellier, FranceClaire-Anne Ponçon, CHRU Montpellier, Centre d�??Investigation Clinique, Montpellier, FranceFrançoise Costa, CHRU Montpellier, Centre d�??Investigation Clinique, Montpellier, FranceClarisse Roux, CHRU Montpel...

FDA Update: Budeprion XL 300 mg Not Therapeutically Equivalent to Wellbutrin XL 300 mg

October 3, 2012 -- The U.S. Food and Drug Administration (FDA) has reviewed new data that indicate Budeprion XL 300 mg (bupropion hydrochloride extended-release tablets), manufactured by Impax Laboratories, Inc., and marketed by Teva Pharmaceuticals... (Source: Drugs.com - Pharma News)

FDA Withdraws Approval of Generic AntidepressantFDA Withdraws Approval of Generic Antidepressant

The antidepressant Budeprion XL 300 mg, a generic form of the extended-release bupropion hydrochloride, is not therapeutically equivalent to Wellbutrin XL 300 mg, the brand-name drug, says the FDA. News Alerts (Source: Medscape Today Headlines)

FDA stops production of generic anti-depressant Budeprion XL 300

Teva Pharmaceuticals has been asked by the US Food and Drug Administration to stop shipping a generic version of a bupropion anti-depressant, after analysis revealed it does not work properly. (Source: Pharmaceutical Technology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

The interaction between dopamine transporter function, gender differences, and possible laterality in depression

Abstract: The Dopamine Transporter (DAT) can reflect the general state of striatal dopamine activity. This current study examined the role of DAT in depressed patients before and after bupropion treatment. Twenty-three patients with major depression were treated with bupropion for 8 weeks. Before and after the treatment, they and 20 normal subjects received the radioligand 99mTc-TRODAT-1 single photon emission tomography scan (SPECT). Subjects were assessed with the Hamilton Depression Rating Scale. All DAT images were spatially normalized to an averaged brain template, and the specific binding ratios of the striatum, caudate, and putamen were calculated according the formulae of: [region counts] / [occipital counts] - 1. Depressed patients had greater DAT availability on both sides of the...

FORFIVO XL (Bupropion Hydrochloride) Tablet, Film Coated, Extended Release [Edgemont Pharmaceuticals, LLC]

Updated Date: Oct 1, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

FDA Withdraws Approval for High-Dose Generic Wellbutrin XL

The FDA has withdrawn its approval for a high-dose extended-release generic bupropion pill called Budeprion XL due to the fact that it was found to be not therapeutically equivalent to the brand name version....Read Full Post (Source: About.com Depression)

Bupropion: Visual hallucinations: case report

(Source: Reactions)

Bupropion/sertraline interaction: Hypersexuality: case report

(Source: Reactions)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Bupropion for Control of Hot Flashes in Breast Cancer Survivors: A Prospective, Double-Blind, Randomized, Crossover, Pilot Phase II Trial

Conclusion: Compared with placebo, bupropion did not control HFs in this group of BC survivors. (Source: Journal of Pain and Symptom Management)

The Genetics of Quitting Smoking

The argument of whether biology has something to do with addiction is silly�??the interaction between nicotine metabolism, bupropion, and quitting smoking can show you why.read more (Source: Psychology Today Addiction Center)

Pharmacological interventions for promoting smoking cessation during pregnancy

Source: Cochrane Area: Evidence &#62; Disease Focused Reviews Background Smoking in pregnancy is a substantial public health problem. When used by non-pregnant smokers, pharmacotherapies [nicotine replacement therapy (NRT), bupropion and varenicline] are effective treatments for smoking cessation, however, their efficacy and safety in pregnancy remains unknown. &#160; &#160; Objectives To determine the efficacy and safety of smoking cessation pharmacotherapies, including NRT, varenicline and bupropion (or any other medications) when used to support smoking cessation in pregnancy. &#160; Search methods We searched the Pregnancy and Childbirth Group's Trials Register (5 March 2012), checked references of retrieved studies and contacted authors in the field. &#160; &#160; ...

Mono- and combination drug therapies in hospitalized patients with bipolar depression. Data from the European drug surveillance program AMSP

Conclusion: Combinations of antidepressants (SSRI, mirtazapine, venlafaxine) with mood stabilizers (lithium, valproic acid, lamotrigine) and / or atypical antipsychotics (quetiapine, olanzapine) are common. Of most of those combinations the efficacy has not been studied. The use of aripiprazole and the concomitant use of two or three antidepressants contrast the guidelines. (Source: BMC Psychiatry - Latest articles)

BUPROPION HYDROCHLORIDEtablet, Film Coated [Major Pharmaceuticals]

Updated Date: Sep 19, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Review: Varenicline is better than bupropion but not nicotine patch for smoking abstinence in adults.

CONCLUSIONS Varenicline is better than placebo or bupropion and does not differ from the nicotine patch for smoking abstinence. Varenicline increases serious adverse events compared with placebo.Varenicline for smoking cessation in adults*OutcomesComparisonNumber of trials (n)Weighted event ratesRBI (95% CI)NNT (CI)Continuous or sustained abstinence at �?� 24 wkStandard-dose varenicline�?� vs placebo14 (6166)27% vs 12%127% (102 to 155)7 (6 to 8)Point prevalence abstinence at 24 wkStandard-dose varenicline vs nicotine patch2 (778)38% vs 34%13% (-6 to 35)Not significantContinuous abstinence at 52 wkStandard-dose varenicline vs bupropion3 (1622)21% vs 14%52% (22 to 88)15 (10 to 25)Abstinence at 52 wkLower-dose varenicline vs placebo4 (1272)21% vs 10%109% (56 to 178)10 (8 to 15)Standard vs lo...

APLENZIN (Bupropion Hydrobromide) Tablet, Extended Release [Sanofi-Aventis U.S. LLC]

Updated Date: Sep 13, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Medications help adults quit smoking

Adults are more likely to successfully quit smoking if they take bupropion, varenicline (Chantix), or a nicotine patch, than those who attempt to quit without medication, according to the results of an ongoing prospective cohort survey published by the journal Addiction. (Source: Drug Topics - Top News)

A case of bupropion-induced stuttering

Conclusion: Neuroimaging and pharmacological studies have implicated dopamine in the pathophysiology of stuttering. Bupropion's ability to increase dopamine in the frontal cortex was suspected to have been involved in this patient's stuttering. However, further research is needed before causality can be assured. (Source: General Hospital Psychiatry)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

BUPROPION HYDROCHLORIDEtablet, Film Coated, Extended Release [Mylan Pharmaceuticals Inc.]

Updated Date: Sep 5, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

E-cigarettes 'may damage lungs'

Conclusion The preliminary findings of this small study suggest the potential harmful effects of e-cigarettes on a person�??s lung function. However, limited conclusions can be drawn from this press release and conference abstract. Scientific research is often presented first at conferences. It gives researchers a chance to speak about their results and discuss them with their peers. However, the results they present are often preliminary, and don�??t have to go through the same peer-review quality assurance process that is needed for publication in a journal. Also, as conference presentations are summarised in very brief �??abstracts�?� for the public, very limited details are usually available on the study�??s methods and results. This makes it difficult to judge the study�??s strengths ...

Bilateral pallidal necrosis and cardiac toxicity in a patient with venlafaxine and bupropion overdose.

Authors: Lin YH, Huang E, Chien YL PMID: 22952082 [PubMed - in process] (Source: The American Journal of Psychiatry)

BUPROPION HYDROCHLORIDE (SR) (Bupropion Hydrochloride) Tablet, Film Coated, Extended Release [Wockhardt Limited]

Updated Date: Aug 31, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BUPROPION HYDROCHLORIDE (SR) (Bupropion Hydrochloride) Tablet, Film Coated, Extended Release [Wockhardt USA LLC.]

Updated Date: Aug 31, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Use of Bupropion in the Treatment of Sexual Dysfunction

ACS Medicinal Chemistry LettersDOI: 10.1021/ml300244w (Source: ACS Medicinal Chemistry Letters)

The effect of smoking cessation pharmacotherapies on pancreatic beta cell function.

Authors: Woynillowicz AK, Raha S, Nicholson CJ, Holloway AC Abstract The goal of our study was to evaluate whether drugs currently used for smoking cessation (i.e., nicotine replacement therapy, varenicline [a partial agonist at nicotinic acetylcholine receptors (nAChR)] and bupropion [which acts in part as a nAChR antagonist]) can affect beta cell function and determine the mechanism(s) of this effect. INS-1E cells, a rat beta cell line, were treated with nicotine, varenicline and bupropion to determine their effects on beta cell function, mitochondrial electron transport chain enzyme activity and cellular/oxidative stress. Treatment of INS-1E cells with equimolar concentrations (1μM) of three test compounds resulted in an ablation of normal glucose-stimulated insulin secretion b...

Bupropion/lithium: Feeding problems? and hypotonia, after in utero exposure: 2 case reports

(Source: Reactions)

WELLBUTRIN XL (Bupropion Hydrochloride) Tablet, Extended Release [STAT Rx USA LLC]

Updated Date: Aug 24, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Pharmacokinetic Interaction between Prasugrel and Ritonavir in Healthy Volunteers

Abstract The new anti�?�aggregating agent prasugrel is bioactivated by cytochromes P450 (CYP) 3A and 2B6. Ritonavir is a potent CYP3A inhibitor and was shown in vitro as a CYP2B6 inhibitor. The aim of this open�?�label cross�?�over study was to assess the effect of ritonavir on prasugrel active metabolite (prasugrel�?�AM) pharmacokinetics in healthy volunteers. Ten healthy male volunteers received 10 mg prasugrel. After at least a week washout, they received 100 mg ritonavir, followed by 10 mg prasugrel 2 hr later. We used dried blood spot sampling method to monitor prasugrel�?�AM pharmocokinetics (Cmax, t1/2, tmax, AUC0�?�6h) at 0, 0.25, 0.5, 1, 1.5, 2, 4 and 6 hr after prasugrel administration. A �??cocktail�?� approach was used to measure CYP2B6, 2C9, 2C19 and 3A activities. In the pres...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effectiveness of stop�?�smoking medications: findings from the International Tobacco Control (ITC) Four Country Survey

ConclusionsConsistent with evidence from randomized controlled trials, smokers in the United Kingdom, Canada, Australia and the United States are more likely to succeed in quit attempts if they use varenicline, bupropion or nicotine patch. Previous population studies that failed to find an effect failed to control adequately for important sources of bias. (Source: Addiction)

A retrospective analysis of two randomized trials of bupropion for methamphetamine dependence: Suggested guidelines for treatment discontinuation/augmentation

Discussion: The findings provide preliminary evidence to guide clinical decisions for moderate MA users receiving bupropion. The results are consistent with data from the smoking cessation literature and may highlight the importance of early response in addiction treatment. (Source: Drug and Alcohol Dependence)

Cognitive evaluation of bupropion sustained release in heavy tobacco smokers using event-related potentials.

CONCLUSIONS. The reduction of P3a in the frontal area may be due to the decreased distractibility of task-irrelevant novel events, which may mean an augmentation of focused attention to task-relevant target events. The increases in the P3b and P2 amplitudes for target events in the parietal area are very suggestive of this hypothesis, since these components reflect the response to task-relevant target events. Meanwhile, the increased P2 latency for standard events may reflect reduced attention resources for the processing of standard events due to increased attention resources allocated for task-relevant target events. Decreased distractibility and increased attention are believed to be caused by bupropion. PMID: 22864270 [PubMed - in process] (Source: Medicina (Kaunas))

CADTH Rapid Response Report: Pharmacological smoking cessation interventions for patients with cardiovascular conditions- review of safety and guidelines

Source: Canadian Agency for Drugs and Technologies in Health (CADTH) Area: News The rapid review by the Canadian Agency for Drugs and Technologies in Health (CADTH) summarises the available safety evidence for varenicline, bupropion, and nicotine replacement therapy) NRT in patients with cardiovascular disease (CVD). This noted that the efficacy of these agents in patients with CVD has been assessed in well-conducted RCTs and systematic reviews. However, the majority of these studies were not specifically designed to fully assess the safety of smoking cessation pharmacotherapy. There were no head-to-head trials or indirect comparisons of different active treatments for smoking cessation. Therefore, uncertainty remains regarding the comparative safety of these agents in patients with vario...

CADTH Rapid Response Report: Pharmacological smoking cessation interventions for patients with cardiovascular conditions

Source: Canadian Agency for Drugs and Technologies in Health (CADTH) Area: News The rapid review by the Canadian Agency for Drugs and Technologies in Health (CADTH) summarises the available safety evidence for varenicline, bupropion, and nicotine replacement therapy (NRT) in patients with cardiovascular disease (CVD). This noted that the efficacy of these agents in patients with CVD has been assessed in well-conducted RCTs and systematic reviews. However, the majority of these studies were not specifically designed to fully assess the safety of smoking cessation pharmacotherapy. There were no head-to-head trials or indirect comparisons of different active treatments for smoking cessation. Therefore, uncertainty remains regarding the comparative safety of these agents in patients with vari...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Weight Gain and Glucose Dysregulation with Second-Generation Antipsychotics and Antidepressants:

A Review for Primary Care Physicians Mehrul Hasnain, MD; R. Vieweg W. Victor, MD; Bruce Hollett, MD DOI: 10.3810/pgm.2012.07.2577 Abstract: Second-generation antipsychotics (SGAPs) and second-generation antidepressants (SGADs) have multiple US Food and Drug Administration&ndash;approved indications and are frequently prescribed by primary care physicians. We review the relative potential of these drugs to cause weight gain and glucose dysregulation, and offer clinical guidance to minimize and manage this risk. Among SGAPs, clozapine and olanzapine have a high risk for causing weight gain and glucose dysregulation; iloperidone, paliperidone, quetiapine, and risperidone have a medium risk; and aripiprazole, asenapine, lurasidone, and ziprasidone have a low risk. Young, drug-na&iu...

BUDEPRION SR (Bupropion Hydrochloride) Tablet, Extended Release [Teva Pharmaceuticals USA Inc]

Updated Date: Aug 8, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BUPROPION HYDROCHLORIDEtablet, Film Coated [Mylan Pharmaceuticals Inc.]

Updated Date: Aug 7, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BUPROPION HYDROCHLORIDEtablet, Film Coated [Preferred Pharmaceuticals,Inc.]

Updated Date: Aug 6, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

A comparison of three smokeless tobacco dependence measures.

Authors: Ebbert JO, Severson HH, Danaher BG, Schroeder DR, Glover ED Abstract Smokeless tobacco (ST) use is associated with tobacco dependence and long-term adverse health consequences. Clinical and research tools that can accurately assess ST dependence are needed to improve research and treatment of ST users. Measures of ST dependence have been developed to address this need. We used data from a study evaluating the effectiveness of bupropion sustained release for the treatment of ST use (N=225) to compare the Fagerström Tolerance Questionnaire for Smokeless Tobacco (FTQ-ST) users, the Severson Smokeless Tobacco Dependency Scale (SSTDS), and the Glover-Nilsson Smokeless Tobacco Behavioral Questionnaire (GN-STBQ). We observed that despite the intention of the scale: (1) all scale...

BUPROPION HYDROCHLORIDEtablet, Film Coated [Lake Erie Medical Surgical Supply DBA Quality Care Products LLC]

Updated Date: Aug 2, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BUPROPION HYDROCHLORIDEtablet, Film Coated, Extended Release [Lake Erie Medical Surgical Supply DBA Quality Care Products LLC]

Updated Date: Aug 2, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BUPROPION HYDROCHLORIDEtablet, Film Coated [Teva Pharmaceuticals USA Inc]

Updated Date: Aug 1, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Intravenous lipid emulsions for treating toxicoses

Intravenous lipid emulsion (ILE) is commonly used in veterinary medicine as a fat component for parenteral nutrition (PN), but new information indicates that it may be a promising new treatment for some toxicoses. The first work was performed in the human arena where ILE was used to treat local anesthetic overdoses. More recent literature on humans has shown ILE to help in the treatment of tricyclic antidepressants, calcium channel blockers, beta blockers, bupropion, haloperidol, hydrochloroquin, flecanide, and carbamazepine toxicoses. In human medicine, ILE is reserved for life-threatening toxicoses or after conventional therapies have not worked. In veterinary medicine, there is no �??standard of care�?� that has to be followed, and many animals are treated with ILE much earlier in the d...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Lipid emulsion therapy for poisonings: a review

This article reviews the history of intravenous lipid emulsion (ILE) as a treatment for poisoning, proposed mechanisms, laboratory and clinical evidence relating to ILE, dosing, and potential side effects. Interest in ILE as therapy for poisoning began with the serendipitous discovery that pretreatment with lipid emulsion protected animals from the effects of systemic bupivacaine toxicity. Although the exact mechanism responsible for this protective effect, possibly explanations include: the &#8220;lipid sink&#8221; or portioning mechanism, increased levels of myocardial fatty acid fuel, and direct isotopic effect. Multiple mechanisms may be active. Although laboratory data to date are not totally conclusive �?? and case reports are difficult to interpret because of numerous confounding v...

WELLBUTRIN XL (Bupropion Hydrochloride) Tablet, Extended Release [Valeant Pharmaceuticals North America LLC]

Updated Date: Jul 30, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

A dopamine/noradrenaline reuptake inhibitor improves performance in the heat, but only at the maximum therapeutic dose

A maximal dose of bupropion has enabled subjects to maintain a higher power output than reported during the placebo session in the heat. Because this drug is taken in different doses it is important to know if there is a dose�??response relationship with regard to exercise at high ambient temperature. Ten well�?�trained male cyclists ingested placebo (pla; 200�??mg) or bupropion (50%, 75%, 100% of maximal dose: bup50: 150�??mg; bup75: 225�??mg; bup100: 300�??mg) the evening before and morning of the experimental trial. Trials were conducted in 30�??°C (humidity 48%). Subjects cycled for 60�??min at 55% Wmax, immediately followed by a time trial to measure performance. Bup100 improved performance (pla: 33'42�?��??~+mn~�??2'06�?�; bup100: 32'06�?��??~+mn~�??1'54�?�; P�??=�??0.035). Bupropion incr...

Platelet count alterations associated with escitalopram, venlafaxine and bupropion in depressive patients

The objective of the present study was to evaluate changes in platelet counts on three different kinds of antidepressant. All subjects (n�??=�??131) in their drug�?�naïve state had been diagnosed with depression. Escitalopram (n�??=�??42), venlafaxine (n�??=�??50) and bupropion (n�??=�??39) were prescribed, and platelet count was measured before and after 1�??month of treatment and compared. Decrease in platelet count on escitalopram was significant, while the others were not. These findings suggest that escitalopram may be associated with decreased platelet count, and bupropion is less likely to exert an influence on platelet count. (Source: Psychiatry and Clinical Neurosciences)

Cost-Effectiveness of Varenicline Versus Bupropion, Nicotine-Replacement Therapy, and Unaided Cessation in Greece.

CONCLUSION: The findings from the present study suggest that, compared with the widely used treatment options bupropion and NRT, as well as unaided cessation, varenicline may enhance smoking-cessation treatment outcomes while substantially reducing the overall costs of smoking to the health care system. PMID: 22818870 [PubMed - as supplied by publisher] (Source: Clinical Therapeutics)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Interaction of antidepressant and antipsychotic drugs with the human organic cation transporters hOCT1, hOCT2 and hOCT3

Abstract&nbsp;&nbsp;Besides the three antidepressant-sensitive, Na+- and Cl�??-dependent monoamine transporters, Na+-independent organic cation transporters (OCTs) are known to transport monoamines. However, little is known about the interactions of psychotropic drugs with human (h) OCTs. In the present study, a series of diverse antidepressant and antipsychotic drugs were examined for their inhibitory potency at hOCT1, hOCT2 and hOCT3 by measuring inhibition of [3H]-MPP+ uptake into HEK293 cells stably expressing one of the three hOCTs. The inhibitory potencies (IC50s) ranged from 1 to 900&nbsp;μM. Most of the examined drugs showed highest inhibitory potency at hOCT1 which is very sparsely expressed in the brain and mainly involved in renal and hepatic clearance of cationic drugs. At ...

Bupropion versus methylphenidate in the treatment of children with attention�?�deficit/hyperactivity disorder: randomized double�?�blind study

ConclusionsBupropion has a comparable safety and efficacy profile with methylphenidate in children and adolescents with ADHD. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)

Dietary intake after smoking cessation among weight-concerned women smokers.

This study is the first documentation of energy and macronutrient intake during smoking cessation treatment using a validated 24-hr dietary recall methodology. Although cessation was associated with overall increases in energy intake among women, neither bupropion nor weight concerns treatment affected energy or macronutrient intake. Future research to understand the relation between cessation and dietary intake needs to replicate and extend these findings to elucidate how, if at all, smoking cessation affects dietary intake. (PsycINFO Database Record (c) 2013 APA, all rights reserved) (Source: Psychology of Addictive Behaviors)

Psychotropic-related hip fractures: meta-analysis of first-generation and second-generation antidepressant and antipsychotic drugs.

CONCLUSIONS: All drug classes studied-first- and second-generation antipsychotics and antidepressants-were associated with an increased risk of hip fracture in predominantly older adult populations. PMID: 22811347 [PubMed - in process] (Source: The Annals of Pharmacotherapy)

BUPROPION HYDROCHLORIDEtablet, Film Coated, Extended Release [NCS HealthCare Of KY, Inc Dba Vangard Labs]

Updated Date: Jun 22, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

APLENZIN (Bupropion Hydrobromide) Tablet, Extended Release [Sanofi-Aventis U.S. LLC]

Updated Date: Jun 19, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Uterine Blood Flow in a Psychiatric Population: Impact of Maternal Depression, Anxiety, and Psychotropic Medication

Conclusions: Contrary to a popular hypothesis, depression and anxiety-associated reductions in UBF may not be a pathway by which risk is conferred during prenatal development. However, while requiring replication, our findings suggest that prenatal bupropion exposure may be associated with reductions in UBF. (Source: Biological Psychiatry)

The effects of most commonly prescribed second generation antidepressants on driving ability: a systematic review

This article provides a systematic review of published studies (1980�??2011) on commonly prescribed newer antidepressants and driving performance. A total of 21 studies could be included in the review, indicating that there is a lack of controlled patient studies. Investigations on newer antidepressants were frequently undertaken in healthy subjects focusing on acute or subchronic effects of application, predominately in young male participants, with dosages usually given in an ambulatory setting. No data, according to selection criteria, were found with respect to agomelatine, duloxetine, bupropion and viloxazine. There is evidence that the SSRIs (citalopram, escitalopram, fluoxetine, fluvoxamine, sertraline, paroxetine) and the SNRI venlafaxine have no deleterious effects on drivin...

Carbonyl reduction of bupropion in human liver.

The objective of this study was to examine the enzyme kinetics of bupropion reduction in human liver. In human liver cytosol, the reduction of bupropion to erythro-and threohydrobupropion was NADPH dependent with Cl(int) values of 0.08 and 0.60 µL·min(-1)mg(-1) protein, respectively. Bupropion reduction in liver microsomes was also NADPH dependent with Cl(int) values of 10.4 and 280 µL·min(-1)mg(-1) protein, respectively. Formation of erythro-and threohydrobupropion in microsomes exceeded that in cytosol by 70 and 170 fold, respectively. Menadione, an inhibitor of cytosolic carbonyl reducing enzymes (e.g. CBRs), inhibited erythro-and threohydrobupropion formation in cytosol with IC(50) of 30 and 54 µM, respectively. In microsomes 18β-glycyrrhetinic acid, an inhibitor of microso...

Bupropion in the treatment of problematic online game play in patients with major depressive disorder

As one of the problematic behaviors in patients with major depressive disorder (MDD), excessive online game play (EOP) has been reported in a number of recent studies. Bupropion has been evaluated as a potential treatment for MDD and substance dependence. We hypothesized that bupropion treatment would reduce the severity of EOP as well as depressive symptoms. Fifty male subjects with comorbid EOP and MDD were randomly assigned to bupropion + education for internet use (EDU) or placebo + EDU groups. The current study consisted in a 12-week, prospective, randomized, double-blind clinical trial, including an eight-week active treatment phase and a four-week post treatment follow-up period. During the active treatment period, Young Internet Addiction Scale (YIAS) scores and the mean time of on...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

BUPROPION HYDROCHLORIDEtablet, Extended Release [Unit Dose Services]

Updated Date: May 29, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BUPROPION HYDROCHLORIDEtablet, Film Coated [Unit Dose Services]

Updated Date: May 29, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BUPROPION HYDROCHLORIDEtablet, Film Coated, Extended Release [Unit Dose Services]

Updated Date: May 29, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Escitalopram-induced word finding difficulty

Abstract: Escitalopram is the most selective serotonin reuptake inhibitor used for treatment of major depressive disorder and generalized anxiety disorder. No available report indicating escitalopram may induce word finding difficulty. Here we are presenting a 50-year-old patient who suffered from escitalopram-induced word finding difficulty and the symptom resolved after replacing with bupropion. Carefully monitoring word finding difficulty and speech fluency during antidepressant treatment is important in clinical practice when using selective serotonin reuptake inhibitors, especially escitalopram. (Source: General Hospital Psychiatry)

High smoking cessation rate in Crohn's disease patients after physician advice �?? The TABACROHN Study

Conclusion: Our results underline that an anti-tobacco strategy mostly based on CD patients´s education and counseling is feasible and effective in helping patients reach complete abstinence. (Source: Journal of Critical Care)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

BUPROPION HYDROCHLORIDEtablet, Film Coated [Cardinal Health]

Updated Date: May 17, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BUPROPION HYDROCHLORIDEtablet, Film Coated, Extended Release [Rebel Distributors Corp]

Updated Date: May 11, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BUPROPION HYDROCHLORIDEtablet, Film Coated, Extended Release [PD-Rx Pharmaceuticals, Inc.]

Updated Date: May 10, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Bupropion: Angioedema presenting as knee monoarthritis: case report

(Source: Reactions)

The association between antidepressant dosage titration and medication adherence among patients with depression

ConclusionsUpward dose titration on antidepressant treatments was associated with improved medication adherence and persistence. For clinicians initiating antidepressant treatment, titrating antidepressant doses may improve patient outcomes. (Source: Depression and Anxiety)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Comparative effectiveness of second�?�generation antidepressants for accompanying anxiety, insomnia, and pain in depressed patients: a systematic review

ConclusionsEvidence guiding the selection of an SGA based on accompanying symptoms of depression is limited. Very few trials were designed and adequately powered to answer questions about accompanying symptoms; analyses were generally of subgroups in larger MDD trials. (Source: Depression and Anxiety)

BUPROPION HYDROCHLORIDE (SR) (Bupropion Hydrochloride) Tablet, Film Coated, Extended Release BUPROPION HYDROCHLORIDEtablet, Film Coated, Extended Release [NorthStar RX LLC]

Updated Date: May 1, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Smoking and depression - a review.

This article examines the relationship between smoking and depression, and reviews the evidence for the use of specific therapies in general practice. Discussion All patients with depression should be asked if they smoke. Smokers with depression have higher nicotine dependence and, after quitting, experience more severe negative moods and are at increased risk of major depression. However, they are motivated to quit and many achieve long term abstinence. Effective strategies for smoking cessation in this population include cognitive behavioural mood management, nicotine replacement therapy, varenicline and bupropion. Additional support and longer courses of treatment may be needed. Smokers with depression should be monitored for mood changes after quitting. Preventive antidepressants may h...

Smoking cessation therapy during pregnancy.

Authors: Cressman AM, Pupco A, Kim E, Koren G, Bozzo P Abstract Question Despite being highly motivated to quit, many of my patients struggle with smoking cessation during pregnancy. Can you comment on the current treatment options and discuss their safety and efficacy during pregnancy? Answer Given the considerable and well-documented adverse effects of antenatal smoking on mother and fetus, pharmacotherapy for smoking cessation should be considered. Available medications include nicotine replacement therapy, sustained-release bupropion, and varenicline. Nicotine replacement therapy and bupropion do not appear to increase the risk of major malformations; however, there is currently limited evidence on the use of varenicline during pregnancy. Given that these agents are only margin...

A novel, nonbinary evaluation of success and failure reveals bupropion efficacy versus methamphetamine dependence: reanalysis of a multisite trial.

Authors: McCann DJ, Li SH Abstract A multisite, double-blind, placebo-controlled trial of bupropion for methamphetamine dependence was reanalyzed using a novel, nonbinary method of evaluating success and failure. The original analysis focused on a group response endpoint (the change in percentage of participants with methamphetamine-free urines each week over the course of the trial) and no significant bupropion effect was observed in the total population of study participants. In this reanalysis, individual participants were regarded as treatment success if they achieved multiple weeks of abstinence lasting through the end of the study, and their degree of success was quantified by calculating the number of beyond-threshold weeks of success (NOBWOS). Thus, setting the threshold at...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

ZYBAN (Bupropion Hydrochloride) Tablet, Film Coated [GlaxoSmithKline LLC]

Updated Date: Apr 27, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

A case of serotonin syndrome precipitated by fentanyl and ondansetron in a patient receiving paroxetine, duloxetine, and bupropion

We report a case of serotonin syndrome during general anesthesia in a patient requiring mastectomy. (Source: Journal of Clinical Anesthesia)

The effects of varenicline on attention and inhibitory control among treatment-seeking smokers

Conclusions&nbsp;&nbsp;The present study demonstrated that varenicline improves lapses in attention among treatment-seeking smokers preparing to make a quit attempt. These findings suggest that the domain of attention may be a good candidate for larger studies of the role of improved cognition in understanding the mechanisms of varenicline treatment for smoking cessation. Content Type Journal ArticleCategory Original InvestigationPages 1-8DOI 10.1007/s00213-012-2700-6Authors Jessica D. Rhodes, Department of Psychology, University at Buffalo, 230 Park Hall, Box 604110, Buffalo, NY 14260, USALarry W. Hawk, Department of Psychology, University at Buffalo, 230 Park Hall, Box 604110, Buffalo, NY 14260, USARebecca L. Ashare, Department of Psychology, University at Buffalo, 230 Park ...

Rapid Clinical Induction of Bupropion Hydroxylation by Metamizole in Healthy Chinese Men

Conclusions: Four�?�day oral administration of metamizole significantly altered the pharmacokinetics of both bupropion and its active metabolite 4�?�hydroxybupropion, and significantly increased the CYP2B6�?�catalyzed bupropion hydroxylation in all of the subjects. Cautions should be made when metamizole was co�?�administered with CYP2B6 substrate drugs.© 2012 The Authors. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society (Source: British Journal of Clinical Pharmacology)

Nicotine receptor partial agonists for smoking cessation.

CONCLUSIONS: Cytisine increases the chances of quitting, although absolute quit rates were modest in two recent trials. Varenicline at standard dose increased the chances of successful long-term smoking cessation between two- and threefold compared with pharmacologically unassisted quit attempts. Lower dose regimens also conferred benefits for cessation, while reducing the incidence of adverse events. More participants quit successfully with varenicline than with bupropion. Two open-label trials of varenicline versus NRT suggested a modest benefit of varenicline but confidence intervals did not rule out equivalence. Limited evidence suggests that varenicline may have a role to play in relapse prevention. The main adverse effect of varenicline is nausea, but mostly at mild to moderate level...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

CADTH rapid review: Clinical and cost effectiveness of funding smoking cessation pharmacotherapy in the workplace

Source: Canadian Agency for Drugs and Technologies in Health (CADTH) Area: News This rapid review from the Canadian Agency for Drugs and Technologies in Health (CADTH) examines the clinical and cost effectiveness of funding smoking cessation pharmacotherapy in the workplace for adult smokers to increase smoking cessation rates? &#160; Evidence from one clinical study and three economic evaluations suggests that funding smoking cessation pharmacotherapy in the workplace results in increased smoking cessation rates and cost savings due to decreased absenteeism and increased productivity, at a low cost to employers. Varenicline appears to be more effective and cost-effective than other smoking-cessation aids such as bupropion and nicotine patches, according to results from two studies. ...

Venlafaxine enhances the effect of bupropion on extracellular dopamine in rat frontal cortex.

Authors: Hudson AL, Lalies MD, Silverstone P Abstract Venlafaxine is recognised as an effective treatment for depression and is known to inhibit the reuptake of serotonin (5-HT) and noradrenaline (NA). Another antidepressant, bupropion, acts to inhibit dopamine (DA) and NA reuptake and is commonly co-administered with other antidepressants to improve the efficacy of the antidepressant effect. The present study was designed to investigate the acute effect of combining the 2 drugs on extracellular levels of 5-HT, DA, and NA in rat frontal cortex using brain microdialysis, with the drugs being administered by intraperitoneal injection (i.p). Bupropion (10 mg/kg body mass, i.p.) alone had no effect on extracellular 5-HT levels, whereas venlafaxine (10 mg/kg, i.p.) alone significantly...

WELLBUTRIN XL (Bupropion Hydrochloride) Tablet, Extended Release [Lake Erie Medical Surgical Supply DBA Quality Care Products LLC]

Updated Date: Apr 16, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Cochrane Quality and Productivity topic: Relapse prevention interventions for smoking cessation

Source: NHS Evidence Area: News Cochrane quality and productivity topics highlight potential disinvestment opportunities that can be used by the NHS to meet its overall QIPP targets, and include calculations of potential cost savings if implemented. The focus of this topic is a Cochrane review of 54 studies that examined the various options available to prevent relapse in people who had given up smoking. &#160; The majority of the studies examined behavioural methods in patients who had achieved abstinence for circumstantial reasons such as being pregnant, an inpatient or being recruited into the military. There was little evidence to show that any benefit was gained from the behavioural interventions studied and little evidence to support the use of bupropion or nicotine replacement ...

Changes in health-related quality of life with smoking cessation treatment

Conclusion: Treatment with varenicline and bupropion SR for smoking cessation resulted in improved self-control and health transition that was mediated in large part by continuous smoking abstinence. (Source: The European Journal of Public Health)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Bupropion overdose: Ventricular tachycardia, QT interval prolongation and status epilepticus, treated with charcoal haemoperfusion: case report

(Source: Reactions)

Recent advances in the pathophysiology and pharmacological treatment of obesity

Conclusion:�?? Despite recent setbacks in the pharmacotherapy of obesity (withdrawal of rimonabant and sibutramine), many compounds are in phase II/III trials. The future holds promise for a new drug that alone or in combination with an existing agent could target the initial pathophysiology and morbidities associated with obesity. (Source: Journal of Clinical Pharmacy and Therapeutics)

BUPROPION HYDROCHLORIDEtablet, Film Coated [Aphena Pharma Solutions - Tennessee, Inc.]

Updated Date: Mar 29, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Recent advances in the pathophysiology and pharmacological treatment of obesity

Conclusion:�?? Despite recent setbacks in the pharmacotherapy of obesity (withdrawal of rimonabant and sibutramine), many compounds are in phase II/III trials. The future holds promise for a new drug that alone or in combination with an existing agent could target the initial pathophysiology and morbidities associated with obesity. (Source: Journal of Clinical Pharmacy and Therapeutics)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Bupropion: Diplopia: case report

(Source: Reactions)

Bupropion: First report of uveal effusion and angle closure glaucoma: case report

(Source: Reactions)

Promoting smoking cessation.

Authors: Larzelere MM, Williams DE Abstract Cigarette smoking causes significant morbidity and mortality in the United States. Physicians can use the five A's framework (ask, advise, assess, assist, arrange) to promote smoking cessation. All patients should be asked about tobacco use and assessed for motivation to quit at every clinical encounter. Physicians should strongly advise patients to quit smoking, and use motivational interviewing techniques for patients who are not yet willing to stop smoking. Clinical contacts with unmotivated patients should emphasize the rewards and relevance of quitting, as well as the risks of smoking and anticipated barriers to abstinence. These messages should be repeated at every opportunity. Appropriate patients should be offered pharmacologic as...

BUPROPION HYDROCHLORIDEtablet, Extended Release [REMEDYREPACK INC. ]

Updated Date: Mar 12, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BUPROPION HYDROCHLORIDEtablet, Film Coated, Extended Release [Par Pharmaceutical, Inc.]

Updated Date: Mar 8, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

BUPROPION HYDROCHLORIDEtablet, Film Coated, Extended Release [Par Pharmaceuticals, Inc.]

Updated Date: Mar 7, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Cigarette smoking as a target for potentiating outcomes for methamphetamine abuse treatment

Conclusions.Initial smoking status did not impact treatment outcomes. Among smokers, results suggest that bupropion may dissociate cigarette and MA use. The effect was modest and a precise pharmacological mechanism remains elusive. Cholinergic systems may be relevant for MA use outcomes. Future studies should continue to assess the role of smoking in MA treatment outcomes.[Brensilver M, Heinzerling KG, Swanson A�?�N, Telesca D, Furst BA, Shoptaw SJ. Cigarette smoking as a target for potentiating outcomes for methamphetamine abuse treatment. Drug Alcohol Rev 2012] (Source: Drug and Alcohol Review)

BUPROPION HYDROCHLORIDEtablet, Extended Release [American Health Packaging]

Updated Date: Mar 2, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BUPROPION HYDROCHLORIDEtablet, Film Coated [APHENA PHARMA SOLUTIONS - TENNESSEE, INC.]

Updated Date: Mar 2, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Bupropion After Nonresponse or Partial Response to an SSRI or SNRI?

This is the third in a series of occasional columns that aim to help clinicians interpret research related to a clinical question. (Source: Psychiatric Times)

Interactions between dopamine transporter and cannabinoid receptor ligands in rhesus monkeys

Conclusions&nbsp;&nbsp;Dopamine release and/or inhibition of dopamine transport blocks detection of �?9-THC and is potentially the mechanism by which some therapeutics (e.g., bupropion) reduce the subjective effects of marijuana and enhance the subjective effects of marijuana withdrawal. Content Type Journal ArticleCategory Original InvestigationPages 1-14DOI 10.1007/s00213-012-2661-9Authors David R. Schulze, Department of Pharmacology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USAF. Ivy Carroll, Organic and Medicinal Chemistry, Research Triangle Institute, Research Triangle Park, Durham, NC, USALance R. McMahon, Department of Pharmacology, The University of Texas Health Science Center at San Antonio, 7703 F...

Brief opportunistic smoking cessation interventions: a systematic review and meta�?�analysis to compare advice to quit and offer of assistance

Conclusions�?? Physicians may be more effective in promoting attempts to stop smoking by offering assistance to all smokers than by advising smokers to quit and offering assistance only to those who express an interest in doing so. (Source: Addiction)

Assessment of Depression among African American Light Smokers

Given the relationship between depression and smoking, we compared the two-item Patient Health Questionnaire (PHQ-2) and 10-item Center for Epidemiological Studies Depression Scale (CESD-10) in assessing depressive symptoms among African American light smokers in a clinical trial of bupropion. Of 539 participants, 21.3 percent reported significant depressive symptoms on the PHQ-2, 31.0 percent screened positive per CESD-10, 36.8 percent reported symptoms on either, and 15.6 percent screened positive on both (r = 0.47, p &lt; .001). Having depressive symptoms was associated with less education, decreased positive affect and social support, and greater levels of negative affect and perceived stress. Cessation treatment should assess depression and address these symptoms. (Source: Journal of ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

BUPROPION HYDROCHLORIDEtablet, Extended Release [Actavis South Atlantic LLC]

Updated Date: Feb 27, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Table of Contents

AbstractStudy Looks at How Mania Drugs Differentially Act on Young BrainsRisperidone Superior to Lithium, Divalproex for Bipolar; Some Adverse EventsWhat is the Evidence for the Use of Bupropion in the Treatment of Attention�?�Deficit/Hyperactivity Disorder (ADHD) in Children and Adolescents?Brain Activity Changes in Depressed Youths Taking FluoxetineParent Training in Combination With Risperidone Shows BenefitTreating Preschool OCD With FluoxetineFrequency, Patterns of Use for Antipsychotic Medications in Canadian YouthRisperidone and Parent Training for PDDSertraline Examined for PTSD in Burned ChildrenRisperidone Linked to Incontinence in a Child With AutismNew Warning and Adverse Events for ChantixNew Precaution Listed for Zyban Sustained�?�Release (Source: The Brown University Child a...

Bupropion for Smoking Cessation in African American Light Smokers: A Randomized Controlled Trial

Conclusions Bupropion SR was effective in promoting smoking cessation during the medication phase of treatment but showed no effect on long-term smoking cessation among African American light smokers. More research is needed to identify strategies for sustaining abstinence among African American light smokers. (Source: JNCI)

Reversal of SSRI-Associated Apathy Syndrome by Discontinuation of Therapy (March).

CONCLUSIONS:In some patients SSRIs may cause an apathy syndrome that can be reversed through discontinuation of the agent. When evaluating patients being treated with an SSRI, clinicians should have a high degree of suspicion and specifically inquire for this iatrogenic form of apathy syndrome. PMID: 22353235 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)

Carbonyl reduction of bupropion in human liver.

The objective of this study was to examine the enzyme kinetics of bupropion reduction in human liver. 2.�??In human liver cytosol, the reduction of bupropion to erythro-and threohydrobupropion was NADPH dependent with Cl(int) values of 0.08 and 0.60 µL·min(-1)mg(-1) protein, respectively. Bupropion reduction in liver microsomes was also NADPH dependent with Cl(int) values of 10.4 and 280 µL·min(-1)mg(-1)protein, respectively. Formation of erythro-and threohydrobupropion in microsomes exceeded that in cytosol by 70 and 170 fold, respectively. 3.�??Menadione, an inhibitor of cytosolic carbonyl reducing enzymes (e.g. CBRs), inhibited erythro-and threohydrobupropion formation in cytosol with IC(50) of 30 and 54 µM, respectively. In microsomes 18β-glycyrrhetinic acid, an inhibitor of micr...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Association between polymorphism SLC6A3 3&#8217;UTR VNTR and response to treatment of nicotine dependence

Conclusion: More studies are needed to assess whether the presence of polymorphism SLC6A3 3�?UTR VNTR could be associated with a better response to treatment of nicotine dependence. (Source: Jornal Brasileiro de Psiquiatria)

Influence of acute bupropion pre�?�treatment on the effects of intranasal cocaine

Conclusions�?? The atypical antidepressant, bupropion, acutely appears to reduce preference for intranasal cocaine versus a small amount of money but to increase reported positive experiences of the drug. (Source: Addiction)

BUPROPION HYDROCHLORIDEtablet, Film Coated, Extended Release [Par Pharmaceutical, Inc.]

Updated Date: Feb 10, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Comparative Dynamics of Four Smoking Withdrawal Symptom Scales

Conclusion:�?? Among a number of different withdrawal symptoms (urge�?�to�?�smoke, negative affect, physical symptoms, and hunger) urge�?�to�?�smoke trajectory parameters (level, slope, and volatility) over the first 7 days of smoking cessation show the strongest prediction of both short and long term relapse. Other withdrawal symptoms increase the predictive ability by negligible amounts. (Source: Addiction)

BUPROPION HYDROCHLORIDEtablet, Film Coated, Extended Release [American Health Packaging]

Updated Date: Feb 8, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Bupropion: Partial status epilepticus: case report

(Source: Reactions)

BUPROPION HYDROCHLORIDEtablet, Film Coated [Cardinal Health]

Updated Date: Feb 1, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Antidepressants and the risk of abnormal bleeding during spinal surgery: a case�??control study

Conclusion&nbsp;&nbsp;Clinicians treating patients who are planning to undergo elective spinal surgery and are on an antidepressant medication should be aware of this potential effect and should consider tapering off the serotonergic antidepressant prior to surgery. Content Type Journal ArticleCategory Original ArticlePages 1-9DOI 10.1007/s00586-011-2132-8Authors Amirali Sayadipour, Division of Spinal Surgery, Department of Orthopaedic Surgery, The Rothman Institute, Thomas Jefferson University, 925 Chestnut St, 5th floor, Philadelphia, PA 19107, USARajnish Mago, Department of Psychiatry, Thomas Jefferson University, Philadelphia, USAChristopher K. Kepler, Division of Spinal Surgery, Department of Orthopaedic Surgery, The Rothman Institute, Thomas Jefferson University, 925 Ches...

Neuromodulators for pain management in rheumatoid arthritis

Source: Cochrane Library Area: Evidence &#62; Drug Class Focused Reviews Background Pain management is a high priority for patients with rheumatoid arthritis (RA). Despite deficiencies in research data, neuromodulators have gained widespread clinical acceptance as adjuvants in the management of patients with chronic musculoskeletal pain. &#160; &#160; Objectives The aim of this review was to determine the efficacy and safety of neuromodulators in pain management in patients with RA. Neuromodulators included in this review were anticonvulsants (gabapentin, pregabalin, phenytoin, sodium valproate, lamotrigine, carbamazepine, levetiracetam, oxcarbazepine, tiagabine and topiramate), ketamine, bupropion, methylphenidate, nefopam, capsaicin and the cannabinoids. &#160; Search ...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Pharmacogenetics of smoking cessation: role of nicotine target and metabolism genes

Abstract&nbsp;&nbsp;Many smokers attempt to quit smoking but few are successful in the long term. The heritability of nicotine addiction and smoking relapse have been documented, and research is focused on identifying specific genetic influences on the ability to quit smoking and response to specific medications. Research in genetically modified cell lines and mice has identified nicotine acetylcholine receptor subtypes that mediate the pharmacological and behavioral effects of nicotine sensitivity and withdrawal. Human genetic association studies have identified single nucleotide polymorphisms (SNPs) in genes encoding nicotine acetylcholine receptor subunits and nicotine metabolizing enzymes that influence smoking cessation phenotypes. There is initial promising evidence for a role ...

ZYBAN (Bupropion Hydrochloride) Tablet, Film Coated [GlaxoSmithKline LLC]

Updated Date: Jan 27, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Neuromodulators for pain management in rheumatoid arthritis.

CONCLUSIONS: There is currently weak evidence that oral nefopam, topical capsaicin and oromucosal cannabis are all superior to placebo in reducing pain in patients with RA. However, each agent is associated with a significant side effect profile. The confidence in our estimates is not strong given the difficulties with blinding, the small numbers of participants evaluated and the lack of adverse event data. In some patients, however, even a small degree of pain relief may be considered worthwhile. Until further research is available, given the relatively mild nature of the adverse events, capsaicin could be considered as an add-on therapy for patients with persistent local pain and inadequate response or intolerance to other treatments. Oral nefopam and oromucosal cannabis have more signif...

Interventions for preventing weight gain after smoking cessation.

CONCLUSIONS: Although some pharmacotherapies tested to limit PCWG show evidence of short-term success, other problems with them and the lack of data on long-term efficacy limits their use. Weight management education only, is not effective and may reduce abstinence. Personalised weight management support may be effective and not reduce abstinence, but there are too few data to be sure. One study showed a VLCD increased abstinence but did not prevent WG in the longer term. CBT to accept WG did not limit PCWG and may not promote abstinence in the long term. Exercise interventions significantly reduced weight in the long term, but not the short term. More studies are needed to clarify whether this is an effect of treatment or a chance finding. Bupropion, fluoxetine, NRT and varenicline reduce...

BUPROPION HYDROCHLORIDEtablet, Film Coated, Extended Release [Global Pharmaceuticals, Division Of Impax Laboratories, Inc.]

Updated Date: Jan 26, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Bupropion/alcohol interaction: Aggressive behaviour: case report

(Source: Reactions)

Systematic review of the cost�?�effectiveness of varenicline vs. bupropion for smoking cessation

Conclusions regarding the cost�?�effectives were changed upon sensitivity analysis with the following variables: time horizon, cost of bupropion, efficacy of either drug, age and the incidence of smoking related disease. Varenicline dominated bupropion in most cost�?�effectiveness models. However, applicability of models to clinical practice and variables which changed conclusion of cost�?�effectiveness should be considered in the interpretation of results. (Source: International Journal of Clinical Practice)

BUPROPION HYDROCHLORIDEtablet, Film Coated, Extended Release [H.J. Harkins Company, Inc.]

Updated Date: Jan 20, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Treatments for Methamphetamine Abuse: A Literature Review for the Clinician

The objective of this article is to critically review the literature of METH treatment options. Preclinical research and human research with compounds not yet available commercially in the United States will not be included. A literature review was conducted for research on pharmacological treatments for METH use and addiction. Trial information on the use of sertraline, bupropion, mirtazapine, modafinil, dextroamphetamine, ondansetron, risperidone, aripiprazole, baclofen, and gabapentin was reviewed. Aripiprazole trials appeared in the reviewed literature more frequently than the other medications. Based on the findings of this review, no single medication demonstrated consistent efficacy and each trial contained a variety of methodological limitations. (Source: Journal of Pharmacy Practi...

Baclofen/bupropion overdose: Various toxicities: case report

(Source: Reactions)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Bupropion: Hyperinsulinism (first report) and seizures in a neonate after in utero exposure: case report

(Source: Reactions)

Bilateral Uveal Effusion and Angle-Closure Glaucoma Associated With Bupropion Use [Research Letters]

(Source: Archives of Opthalmology)

Pilot Randomized Clinical Trial of an SSRI vs Bupropion: Effects on Suicidal Behavior, Ideation, and Mood in Major Depression. - Grunebaum MF, Ellis SP, Duan N, Burke AK, Oquendo MA, John Mann J.

This study compared a serotonin reuptake inhibitor with a noradrenergic/dopam... (Source: SafetyLit: All (Unduplicated))

Real world evaluation of three models of NHS smoking cessation service in England

Conclusion: The results suggest that service structure, method of support, healthcare professional involved and pharmacotherapy all play a role in a successful quit. Services must be tailored to support individual needs with patient choice and access to varied services being key factors. (Source: BMC Research Notes)

BUPROPION HYDROCHLORIDE EXTENDED RELEASE SR (Bupropion Hydrochloride) Tablet, Film Coated, Extended Release [Lake Erie Medical DBA Quality Care Products LLC]

Updated Date: Jan 5, 2012 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Unexpected aggressive behaviour: Interaction of bupropion and alcohol. - Chandler P, Herxheimer A.

[Abstract unavailable] Language: Eng... (Source: SafetyLit: All (Unduplicated))

Depression Treatment in Patients With General Medical Conditions: Results From the CO-MED Trial.

CONCLUSIONS Patients with general medical conditions can be safely and effectively treated for MDD with antidepressants with no additional adverse effect or tolerability burden relative to their counterparts without such conditions. Combination therapy is not associated with an increased treatment response beyond that found with traditional monotherapy in patients with MDD, regardless of the presence and number of general medical conditions. PMID: 22230827 [PubMed - in process] (Source: Annals of Family Medicine)

Charcoal hemoperfusion for bupropion overdose with ventricular tachycardia and status epilepticus.

Authors: Chao CT, Wu VC, Wang WJ PMID: 22333014 [PubMed - in process] (Source: J Formos Med Assoc)

BUPROPION HYDROCHLORIDEtablet, Extended Release [REMEDYREPACK INC. ]

Updated Date: Dec 28, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

The anti-inflammatory effects of sympathectomy in murine antigen-induced arthritis are associated with a reduction of Th1 and Th17 responses

Conclusions Sympathetic activity mainly increases the severity of acute episodes of immune-mediated arthritis. Therapeutic reduction of sympathetic activity at acute stages attenuates inflammation, hyperalgesia and proinflammatory immune parameters. (Source: Annals of the Rheumatic Diseases)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

BUPROPION HYDROCHLORIDEtablet [REMEDYREPACK INC. ]

Updated Date: Dec 27, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Brief opportunistic smoking cessation interventions: a systematic review and meta�?�analysis to compare advice to quit and offer of assistance

Conclusions�?? Physicians may be more effective in promoting attempts to stop smoking by offering assistance to all smokers than by advising smokers to quit and only offering assistance to those that express an interest in doing so. (Source: Addiction)

Rates of 5 Common Antidepressant Side Effects Among New Adult and Adolescent Cases of Depression: A Retrospective US Claims Study.

CONCLUSIONS: Prevalence and risk of the 5 side effects varied across types of antidepressants for both adults and adolescents. Results from this study were consistent with prior clinical trials, suggesting that variation in side effect profiles exists in a more generalized managed care population. PMID: 22177545 [PubMed - as supplied by publisher] (Source: Clinical Therapeutics)

Influence of Acute Bupropion Pretreatment on the Effects of Intranasal Cocaine

Conclusions: The atypical anti�?�depressant, bupropion, acutely appears to reduce preference for intranasal cocaine versus a small amount of money but to increase reported positive experiences of the drug. (Source: Addiction)

BUPROPION HYDROCHLORIDEtablet, Extended Release [Actavis South Atlantic LLC]

Updated Date: Dec 13, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Influence of acute bupropion pre�?�treatment on the effects of intranasal cocaine

Conclusions�?? The atypical antidepressant, bupropion, acutely appears to reduce preference for intranasal cocaine versus a small amount of money but to increase reported positive experiences of the drug. (Source: Addiction)

BUPROPION HYDROCHLORIDE EXTENDED-RELEASE (Bupropion Hydrochloride) Tablet, Film Coated, Extended Release [Anchen Pharmaceuticals, Inc.]

Updated Date: Dec 12, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BUPROPION HYDROCHLORIDE XL (Bupropion Hydrochloride) Tablet, Film Coated, Extended Release [Lake Erie Medical DBA Quality Care Products LLC]

Updated Date: Dec 7, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Uliginosin B, a phloroglucinol derivative from Hypericum polyanthemum: A promising new molecular pattern for the development of antidepressant drugs.

In this study we have demonstrated that cyclohexane extract of Hypericum polyanthemum (POL) and its main phloroglucinol derivative uliginosin B (ULI) present antidepressant-like activity in rodent forced swimming test (FST). The involvement of monoaminergic neurotransmission on the antidepressant-like activity of ULI was evaluated in vivo and in vitro. POL 90mg/kg (p.o.) and ULI 10mg/kg (p.o.) reduced the immobility time in the mice FST without altering locomotion activity in the open-field test. The combination of sub-effective doses of POL (45mg/kg, p.o.) and ULI (5mg/kg, p.o.) with sub-effective doses of imipramine (10mg/kg, p.o.), bupropion (3mg/kg, p.o.) and fluoxetine (15mg/kg, p.o.) induced a significant reduction on immobility time in FST. The pretreatment with SCH 23390 (15μg/kg,...

A randomized, single-blind, comparison of duloxetine with bupropion in the treatment of SSRI-resistant major depression

Conclusions: These preliminary results seem to support the hypothesis that in patients unresponsive to SSRIs the administration of antidepressants with different mechanisms of action is an effective switching strategy. Further studies are needed in light of the challenge posed by resistant depression. (Source: Journal of Affective Disorders)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

The triple reuptake inhibitor DOV216,303 exhibits limited antidepressant-like properties in the differential reinforcement of low-rate 72-second responding assay, likely due to dopamine reuptake inhibition

There is a need for antidepressants with novel mechanisms of action. One approach has been to develop compounds that inhibit reuptake of all three monoamines in the central nervous system, for example DOV216,303. Differential reinforcement of low-rate (72-s) responding is a behavioral test that is predictive of antidepressant-like properties. The effects of antidepressant compounds belonging to multiple classes, the anxiolytic diazepam and the antipsychotic haloperidol, were assessed in the DRL-72s task. Subsequently, the antidepressant-like properties of acute DOV216,303 were assessed. The selective serotonin reuptake inhibitor fluvoxamine, the preferential norepinephrine reuptake inhibitor desipramine and the tricyclic antidepressant imipramine exhibited antidepressant-like properties in...

Bupropion for adults with attention�?�deficit hyperactivity disorder: Meta�?�analysis of randomized, placebo�?�controlled trials

Conclusion:�?? The evidence suggests that bupropion is superior to placebo and effective for the treatment of ADHD in adults. However, its acceptability and tolerability were not significantly higher than those of placebo. (Source: Psychiatry and Clinical Neurosciences)

Forfivo XL (Bupropion Hydrochloride) - updated on RxList

Forfivo XL (Bupropion Hydrochloride) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)

Antihypertensives/bupropion/insulin/soya oil emulsion: Cardiogenic shock and bradyasystolic arrest: 2 case reports

(Source: Reactions)

Study protocol for a non-inferiority trial of cytisine versus nicotine replacement therapy in people motivated to stop smoking

DiscussionCytisine appears to be effective compared with placebo, and given its (current) relative low cost may be an acceptable smoking cessation treatment for smokers, particularly those in low- and middle-income countries. Cytisine's 'natural' product status may also increase its acceptability and use among certain groups of smokers, such as indigenous people, smokers in countries where the use of natural medicines is widespread (e.g. China, India), and in those people who do not want to use NRT or anti-depressants to help them quit smoking. However it is important to ascertain the effectiveness of cytisine compared with that of existing cessation treatments.Trial registrationAustralian New Zealand Clinical Trials Registry (ACTRN12610000590066) (Source: BMC Public Health - Latest articl...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Why two smoking cessation agents work better than one: Role of craving suppression.

Conclusion: Suppression of craving on the quit day significantly mediates the clinical effects of monotherapies and combination smoking pharmacotherapies, and the higher abstinence rates for combination therapy versus monotherapies appear primarily due to greater craving suppression. (PsycINFO Database Record (c) 2012 APA, all rights reserved) (Source: Journal of Consulting and Clinical Psychology)

BUPROPION HYDROCHLORIDEtablet, Extended Release [Physicians Total Care, Inc.]

Updated Date: Nov 14, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

WELLBUTRIN (Bupropion Hydrochloride) Tablet, Extended Release [BTA Pharmaceuticals ]

Updated Date: Nov 14, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Suicidal behavior and depression in smoking cessation treatments. - Moore TJ, Furberg CD, Glenmullen J, Maltsberger JT, Singh S.

BACKGROUND: Two treatments for smoking cessation-varenicline and bupropion-carry Boxed Warnings from the U.S. Food and Drug Administration (FDA) about suicidal/self-injurious behavior and depression. However, some epidemiological studies report an increase... (Source: SafetyLit: All (Unduplicated))

Outcomes on the pharmacopsychometric triangle in bupropion�?�SR vs. buspirone augmentation of citalopram in the STAR*D trial

Conclusion:�?? In all domains of the pharmacopsychometric triangle, bupropion�?�SR was superior to buspirone as augmentation therapy in depressed outpatients not responding to citalopram. (Source: Acta Psychiatrica Scandinavica)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

High-Dose Bupropion Wins FDA Nod

(MedPage Today) -- The FDA has approved a new, high-dose formulation of the antidepressant drug bupropion, a pill containing 450 mg of the drug, according to its manufacturer. (Source: MedPage Today Psychiatry)

IntelGenx Announces FDA Approval of Its High Dose Anti-Depressant CPI-300

SAINT LAURENT, Quebec, Nov. 11, 2011 (GLOBE NEWSWIRE) -- IntelGenx Corp. (TSX-V:IGX) (OTCBB:IGXT) ("IntelGenx") today announced that the U.S. Food and Drug Administration (FDA) has approved IntelGenx' lead product, CPI-300, for patients with Major Depressive Disorder. CPI-300 is a novel, high-strength formulation of Bupropion hydrochloride (HCl), the active ingredient in Wellbutrin XL. CPI-300 is the only single dose 450 mg formulation of Bupropion HCl approved by the FDA. (Source: Medical News (via PRIMEZONE))

Bupropion: Hyponatraemia: case report

(Source: Reactions)

BUPROPION HYDROCHLORIDEtablet, Extended Release [Actavis South Atlantic LLC]

Updated Date: Nov 7, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Does acceptance and relationship focused behavior therapy contribute to bupropion outcomes? A randomized controlled trial of functional analytic psychotherapy and acceptance and commitment therapy for smoking cessation.

This study evaluated a treatment combining bupropion with a novel acceptance and relationship focused behavioral intervention based on the acceptance and relationship context (ARC) model. Three hundred and three smokers from a community sample were randomly assigned to bupropion, a widely used smoking cessation medication, or bupropion plus functional analytic psychotherapy (FAP) and acceptance and commitment therapy (ACT). Objective measures of smoking outcomes and self-report measures of acceptance and relationship processes were taken at pretreatment, posttreatment, 6-month, and 1-year follow-up. The combined treatment was significantly better than bupropion alone at 1-year follow-up with 7-day point prevalence quit rates of 31.6% in the combined condition versus 17.5% in the medication...

Another cessation aid goes up in smoke

Two drugs used to help people stop smoking &mdash; varenicline (Chantix) and bupropion (Zyban) &mdash; carry a significantly increased risk of depression and suicidal or self-injurious behavior, according to a new study published in the Public Library of Science. (Source: Health Facts and Fears)

Suicide risk higher with varenicline than other stop-smoking meds

Chantix should not be a first-line choice for smoking cessation, authors of a new paper say. Their study found significantly more cases of suicidal behavior and depression with varenicline than with bupropion or nicotine replacements. (Source: theHeart.org)

Analysis investigates risks of suicidal behavior and depression with smoking cessation treatments

Source: PLoS One Area: News The findings of this American study suggest that varenicline is associated with a significantly increased risk for suicidal behavior and depression. Bupropion, for smoking cessation, was found to be associated with smaller increased risks. &#160; The researchers note that both varenicline and bupropion are treatments for smoking cessation and both carry Boxed Warnings from the United States Food and Drug Administration (U.S FDA) relating to suicidal/self-injurious behavior and depression. They examined the comparative neuropsychiatric safety profiles of varenicline and bupropion with regard to suicidal/self-injurious behavior and depression as reflected in adverse drug event data. Data for serious injury case reports between 1998 and September 2010 from the...

Greater Suicide Risk With Varenicline vs Other Cessation MedsGreater Suicide Risk With Varenicline vs Other Cessation Meds

A comparison study of smoking cessation medications shows that varenicline was associated with significantly more cases of suicidal behavior and depression than bupropion or nicotine replacement therapy. Medscape Medical News (Source: Medscape Today Headlines)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Smoking Cessation Pharmacogenetics: Analysis of Varenicline and Bupropion in Placebo-Controlled Clinical Trials

Authors: David P King, Sara Paciga, Eve Pickering, Neal L Benowitz, Laura J Bierut, David V Conti, Jaakko Kaprio, Caryn Lerman & Peter W Park Keywords: pharmacogenetics&#47;pharmacogenomics; addiction and substance abuse; clinical pharmacology&#47;clinical trials; neuropharmacology; varenicline; bupropion; nicotine; smoking cessation; nicotinic receptors (Source: Neuropsychopharmacology)

Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D.

CONCLUSIONS: Although our findings require replication and functional validation, this study demonstrates the potential of GWAS to discover genes and pathways that could mediate adverse effects of antidepressant medication. PMID: 22041458 [PubMed - as supplied by publisher] (Source: Psychological Medicine)

Design considerations for a study to evaluate the impact of smoking cessation treatment on stimulant use outcomes in stimulant-dependent individuals

Abstract: Cigarette smoking is prevalent in cocaine/methamphetamine-dependent patients and associated with significant morbidity and mortality, yet, the provision of smoking cessation treatment in conjunction with substance use disorder (SUD) treatment is not standard practice. This is due, in part, to clinician concern that combining smoking cessation treatment with SUD treatment could lead to poorer SUD outcomes. The NIDA Clinical Trials Network is conducting a 10-week, two-group, randomized trial to evaluate the impact of providing smoking cessation treatment (SCT) with SUD treatment as usual (TAU), compared to TAU alone, in smokers who are in outpatient treatment for cocaine or methamphetamine dependence. Approximately 528 participants, recruited from 12 community treatment programs, w...

Bupropion No 'Magic Bullet' in Post-MI SmokersBupropion No 'Magic Bullet' in Post-MI Smokers

A trial of bupropion in long-time smokers immediately post-AMI found no benefits of the drug at 1 year, suggesting that despite a 'life-changing event,' smokers struggle to kick the habit. Heartwire (Source: Medscape Today Headlines)

A Novel, Nonbinary Evaluation of Success and Failure Reveals Bupropion Efficacy Versus Methamphetamine Dependence: Reanalysis of a Multisite Trial.

Authors: McCann DJ, Li SH Abstract A multisite, double-blind, placebo-controlled trial of bupropion for methamphetamine dependence was reanalyzed using a novel, nonbinary method of evaluating success and failure. The original analysis focused on a group response endpoint (the change in percentage of participants with methamphetamine-free urines each week over the course of the trial) and no significant bupropion effect was observed in the total population of study participants. In this reanalysis, individual participants were regarded as treatment success if they achieved multiple weeks of abstinence lasting through the end of the study, and their degree of success was quantified by calculating the number of beyond-threshold weeks of success (NOBWOS). Thus, setting the threshold at...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effects of heart disease on depression treatment: results from the COMED study

Abstract: Objective: To determine the impact of self-reported heart disease (HD) on major depressive disorder (MDD) treatment outcomes.Method: This single-blind, 7-month prospective randomized trial enrolled 665 participants, 18�??75 years old, from six primary and nine psychiatric care sites across the USA. Participants had at least moderately severe (baseline 17-item Hamilton Rating Scale of Depression �?�16), nonpsychotic chronic and/or recurrent MDD. Participants with and without self-reported HD were randomized into three treatment groups (1:1:1 ratio): escitalopram plus placebo, bupropion sustained-release plus escitalopram or venlafaxine extended-release plus mirtazapine. The primary outcome (remission) was defined by the last two consecutive 16-item Quick Inventory of Depressive Sy...

Stimulus-Induced Rhythmic, Periodic, or Ictal Discharges in a 13-Year-Old Girl After an Overdose and Respiratory Arrest

Paramedics found a 13-year-old, previously healthy girl with depression at home and unresponsive after overdosing on bupropion and baclofen. She was observed to be in respiratory arrest and bradycardic, with a Glasgow Coma Scale score of 3. Chest compressions were required, and she was intubated. During transport, she was hypothermic with decerebrate posturing, and manifested a 1-minute, self-terminating, generalized tonic-clonic seizure. In the pediatric intensive care unit, she received intermittent doses of lorazepam and fentanyl for sedation. She remained comatose, and continuous video-electroencephalogram monitoring was initiated to evaluate her for nonconvulsive seizures. (Source: Pediatric Neurology)

BUPROPION HYDROCHLORIDEtablet, Film Coated [Sandoz Inc]

Updated Date: Oct 13, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

BUPROPION HYDROCHLORIDEtablet, Film Coated [PD-Rx Pharmaceuticals, Inc.]

Updated Date: Oct 13, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

Pilot Randomized Clinical Trial of an SSRI vs Bupropion: Effects on Suicidal Behavior, Ideation, and Mood in Major Depression

Authors: Michael F Grunebaum, Steven P Ellis, Naihua Duan, Ainsley K Burke, Maria A Oquendo & J John Mann Keywords: depression; unipolar; bipolar; psychopharmacology; clinical pharmacology; clinical trials; mood; anxiety; stress disorders; suicidal behavior; suicidal ideation (Source: Neuropsychopharmacology)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Application of the conditioned taste aversion paradigm to assess discriminative stimulus properties of psychostimulants in rats

Conclusion: These results suggest that discriminative stimulus properties of psychostimulants can be evaluated using the CTA paradigm. (Source: Drug and Alcohol Dependence)

Incremental efficacy of adding bupropion to the nicotine patch for smoking cessation in smokers with a recent history of alcohol dependence: Results from a randomized, double-blind, placebo-controlled study

Conclusions: Findings do not support combining nicotine patch and bupropion for smoking cessation in this population. However, findings support previous studies suggesting the importance of assessing the blind in smoking cessation studies and its possible moderating effect on medication efficacy. Future directions for enhancing smoking cessation outcome in these smokers include investigations of intensive behavioral and pharmacological interventions, including studies of potential interactions between individual genetic differences and medication efficacy. (Source: Drug and Alcohol Dependence)

BUPROPION HYDROCHLORIDEtablet, Extended Release [Eon Labs, Inc.]

Updated Date: Oct 7, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

OBESITY: CVD Risk Cut With Rejected Weight-Loss Drug (CME/CE)

ORLANDO (MedPage Today) -- It appears that the investigational weight-loss combination of naltrexone standard release and bupropion standard release (Contrave) reduces the predicted 10-year risk of cardiovascular events, an analysis of four phase III trials showed. (Source: MedPage Today Pediatrics)

Partial Status Epilepticus after Electroconvulsive Therapy and Medical Treatment with Bupropion

We report a patient who received right unilateral ECT under concomitant treatment with bupropion, a selective noradrenaline- and dopamine-reuptake inhibitor. After the fourth session, a focal status epilepticus occurred, which was pharmacoresistant for the duration of 12 days. We assume that the induction of a status may be facilitated by a lowering of the seizure threshold due to bupropion. An evaluation of drug therapy and control of EEG before and during ECT are recommended, especially when the drug treatment has an influence on the seizure threshold.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Manipulation of Cigarette Craving with Transcranial Magnetic Stimulation

The health risks and societal costs of cigarette smoking are well documented, but the prevalence of smoking among American adults remains high at approximately 20%. Most smokers endorse a desire to quit, but very few (only about 4�??7%) will actually do so in a given year without treatment. Current commonly used treatments for tobacco dependence include nicotine replacement therapy (e.g., patch, gum, and lozenge), varenicline HCl (Chantix), bupropion HCl (Zyban), and group and/or individual psychotherapy. These treatments result in roughly 20�??25% abstinence rates in smokers at 6 months or more after treatment initiation and are therefore considerably better than attempting abstinence without treatment. However, there continues to be a vital need to improve treatments for cigarette smoker...

Bupropion: Aphthous ulcers: case report

(Source: Reactions)

Effects of Race and Ethnicity on Depression Treatment Outcomes: The CO-MED Trial [Articles]

Conclusions: Despite differences in sociodemographic characteristics and comorbidities, when measurement-based care was used, members of different minority groups had similar outcomes when treated with one antidepressant or a combination of two antidepressants. Black participants had the highest attrition rate, an important issue to address in clinical care. (Psychiatric Services 62:1167&ndash;1179, 2011) (Source: Psychiatr Serv)

Neuropsychiatric adverse effects of centrally acting antiobesity drugs.

Conclusion: These findings highlight the need to assess neuropsychiatric adverse events comprehensively using sensitive and validated methods early in the clinical development of candidate antiobesity drugs with a central mechanism of action. PMID: 21951371 [PubMed - in process] (Source: CNS Neuroscience and Therapeutics)

BUPROPION HYDROCHLORIDEtablet, Film Coated [Dispensing Solutions, Inc.]

Updated Date: Sep 30, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Bupropion hydrobromide propanol hemisolvate

The title compound {systematic name: N-[1-(3-chlorophenyl)-1-oxopropan-2-yl]-tert-butanaminium bromide propanol hemisolvate}, C13H19ClNO+·Br�??·0.5C3H8O, crystallizes with two independent bupropion hydrobromide ion pairs and a solvent 1-propanol molecule in the asymmetric unit. In both molecules, the expected proton transfer from HBr to the amino group of the bupropion molecule is observed, and intra- and intermolecular N�??H...Br hydrogen-bond interactions are formed. These interactions link the molecules into hydrogen-bond dimers. The side chains of the two cations have slightly different orientations. The 1-propanol solvent molecule is linked to a bromide ion by an O�??H...Br hydrogen bond. (Source: Acta Crystallographica Section E)

NEJM drops the ball on smoking cessation

A lengthy article in this week�??s New England Journal of Medicine catalogues a variety of approaches to helping smokers quit within the healthcare setting, including counseling, smoking cessation medications such as bupropion and varenicline, as well as conventional nicotine replacement modalities like gum, inhalers, and patches. (Source: Health Facts and Fears)

Can�??t teach an old anti-smoking drug new tricks

A lengthy article in this week�??s New England Journal of Medicine catalogues a variety of approaches to helping smokers quit within the healthcare setting, including counseling, smoking cessation medications such as bupropion and varenicline, as well as conventional nicotine replacement modalities like gum, inhalers, and patches. (Source: Health Facts and Fears)

Assessment of the convulsant liability of antidepressants using zebrafish and mouse seizure models.

Authors: Vermoesen K, Serruys AS, Loyens E, Afrikanova T, Massie A, Schallier A, Michotte Y, Crawford AD, Esguerra CV, de Witte PA, Smolders I, Clinckers R Abstract In the past, antidepressants have been thought to possess proconvulsant properties. This assumption remains controversial, however, because anticonvulsant effects have been attributed to certain antidepressants. To date, it remains unclear which antidepressants can be used for the treatment of patients with epilepsy with depression. The present study was designed to determine the anticonvulsant and/or proconvulsant effects of three antidepressants (citalopram, reboxetine, bupropion) against pilocarpine- and pentylenetetrazole-induced acute seizures in larval zebrafish and mice. In zebrafish, all antidepressants were ant...

BUPROPION HYDROCHLORIDEtablet, Film Coated [Apotex Corp]

Updated Date: Sep 28, 2011 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Find the best <a href="http://www.thejanuarysales.com/">Christmas Sales</a>, <a href="http://www.thejanuarysales.com/">Boxing Day Sales</a> and <a href="http://www.thejanuarysales.com/">January Sales</a> <a href="http://www.thejanuarysales.com/">here</a>.</p></div>

Effects of varenicline and bupropion on cognitive processes among nicotine-deprived smokers.

Nicotine deprivation is associated with craving, negative affect, and difficulty concentrating, which may contribute to subsequent relapse. Bupropion and varenicline are both effective treatments for smoking cessation, and evidence from clinical trials suggests that these treatments increase abstinence rates. However, the mechanism by which these medications reduce relapse remains unclear. Recent research has focused on cognitive processes, such as attention and working memory, which may predict relapse. In addition, there may also be sex differences in cognitive-related deficits during nicotine deprivation. The current sample consisted of 58 (22 females) daily smokers (at least 10 cigarettes per day) randomized to receive bupropion (300 mg/day), varenicline (2 mg/day), or placebo. After a...