Patients
DEPLIN Side Effects Report #SELF-2427
Female patient reported the following DEPLIN side effect(s):I have went through so much, and am going through quite an ordeal. It may be a very complicated case, but I believe you if anyone might be able to help me, and have the resources to those who could. I am hoping you will get this in time to help me soon.I am willing to do whatever it takes to be helped and get my life back.If you had met me before this, you wouldn’t believe I was the same person. *Here is what happened: On 11/6/08 I was a 41 year old functioning woman, who took care of her family, shopped, cooked, laughed, was an avid reader, had close relations with my children. Then it all changed overnight. I was given a pill (Deplin) off label by a pa that I had a very severe reaction to. A 41 year old stable woman does not take a pill, have a reaction, and turn “mental” overnight. I was not treated, have been and am going through hell. I want my life back! Please help me get my life back.On 11/7/08 I was given a pill deplin by a pa at doc office. Within hours of taking it I began to shake uncontrollably, head tremor, burning inside and out, severe burning hands and feet, neuropathy, hard pounding racing heart, stomach cramps, unintelligible thinking, diarhea, muscle twitches, and complete insomnia. I developed an unexplained heightened state with no cause. Intense chills in body, especially in legs, tingling hands and feet, head tremor. Convulsive jerks, odd intrusive thoughts, and much more to describe. It has been intolerable. In the last 100 plus days I only slept 1-4 hours using benadryl and 30-40 nights have not slept at all. I was not treated properly, first hospital never heard of drug, next a doctor said I was nervous and covered my mouth due to the uncontrollable shaking, he had no interest in my story or what happened to me.I also lost the ability to laugh, smile, watch tv, or read, have normal conversations and relations with my children that same night 11/7/08. I have children and a family that needs me back. Just days before taking this pill I was fine, happily planning a remodel of my kitchen. You can confirm all I am telling you with my family and friends. I did have occasional anxiety attacks, which passed easily, and nothing what so ever like this. Od of reg folic acid can cause central nervous system damage. Deplin is different and goes straight to the brain. I cant explain why this happened to me, but it did, and is the 100 percent truth. I Really need your help asap. I lost 15 pounds in first month and only weigh 92 pounds. Previous to this I took 12.5 mgs of diazepam for some anxiety attacks, had taken 6mgs for 14 plus years. I have NO history of any mental illness, this can be confirmed. I have no ins. and ended up seeing a psychiatrist on 2/6/09 who put me on 60mgs of valium to try to help me, but for some very odd reason it only helps the awful heightened state with no external cause, to an extent less expected by the doctor. I still am not sleeping much as he expected this dose would help either. I am so afraid of being at this high dose, but have no choice. I have no compulsions, no bipolar symptoms, or anything that anyone else thinks matches mental illness heard of. As I said, I have no history of mental illness.If it were nerves, the symptoms would stop with the high dose of valium? I get chills constantly, but also sweat at night, and developed joint/connective tissue pain, and popping in joints. My heart races more at night when trying to sleep and upon awakening, but at other times as well, as well as continued internal shaking, tingling in hands and feet. I am in serious trouble! I am afraid for my life and future! I do not have insurance. I am still having symptoms at this high dose of valium, it is not nerves, nor does it feel like any anxiety. Please take me seriously! I need my life to matter to someone. Please Help Me! Some symptoms had subsided some, such as the neuropathy over the past few weeks, and the jerking while half asleep had subsided, but I still have many symptoms and a long way to go. It has been suggested that some of my symptoms match neurological or CNS damage. I don’t know who to believe, or listen to, I just know what happened to me, and that I need help. Maybe it cant be explained, but it happened exactly as I have explained. The Doctor I was seeing is family practice and says she does not know what else to check for. Basic thyroid okay, basic liver okay, blood count okay. I also have rashes/hives that come and go, and have lessened somewhat recently.How is it possible that 60mgs only partially effects me?What else could be happening metabolically or otherwise that this reaction changed in me, physically and mentally?Everything I am telling you is the 100 % honest truth of what occurred and is. I may be asking a lot, but I need your help, and anyone you might confer with.I am no longer going to the clinic where the pa gave me the sample Deplin. I have info on it for your review. Something terrible happened to me that destroyed who I am and my life. If there is anything you can think of, any idea of what might have occurred, what to check for, and if it can be fixed. I would appreciate your help. I have NO history of drug use/abuse, I do not drink at all, and have never abused my prescription. There is something being missed, and I don’t know where else to turn.If you have any resources available to help me, please contact me. I need someone to listen to what happened and help me. I am so scared being at such a high dose of Diazepam (valium) but do not have any other choice right now. I am sorry to bother you, this is out of character for me before now, but I am at the end of what I can take anymore of this and afraid for my future. My husband needs to be out looking for work, and is no longer able to take care of me, this has made me disabled in many ways, and I have no where to turn for treatment and help other than the psychiatrist who is trying to help me. However, he doesn’t have much interest in what happened to me with the drug reaction to deplin, or determining what might be causing my symptoms, other than nerves, which just does not compute.I simply cant stand to go back into that heightened state without the high dose of diazepam, but do not want to continue taking so much either, it is dangerously addicting, but no other choice for now. I pray you will hear my pleas today, and help me. I am asking with all my heart and prayers that you will help me asap.Thank you so very much for your immediate consideration, Sincerely,Jennifer Connelley mjstac@comcast.net
Pamlab makes Deplin. And they dont have to answer to anyone, although Deplin only available by prescription (or sample from your doctors office as in my case) it is NOT FDA approved! It IS NOT really any form of regular Folic Acid in any way shape or form! It is L methylfolate! It does not have to be broken down by the body at all. It goes directly to the brain! It effects all brain chemicals, and according to the pharmacology, which is hard to find by the way, there are adverse reactions. However the company refuses to tell me what those are! They said they dont have to, because they dont have to answer to the FDA! It is basically an overdose of a much stronger form of folic acid, and it is not water soluable either, it is 52 percent plasma protien binding, enough time to stay in your system to cause damage, as it did to me. Pamlab refused to help me when I called them within days of my reaction, and they have refused to connect me with their legal dept. or give me the number to contact them. Blood tests are supposed to be done before being given to patients, but I guess the pa Janee Gillette at the Exodus Healthcare in WVC (Part of Magna Center for Families Medical) simply didnt care, or investigate to know enough about this DRUG and what it was for. She said it was for heavy mentrual cycle. A complete lie! She did no blood tests prior to giving it to me. I was not defiecient in folic acid as a patient would need to be to have this prescribed in the first place! Nor did she care to investigate that is was not supposed to be given to patients with seizure disorders or on anticonvulsants, as I was. But, on the little pamplet, it said NO SIDE EFFECTS or interactions! PAMLAB lies, and they dont care and they dont have to answer to anyone. I plan to get a lawyer and sue both the pa, the health care center, and Pamlab. I have no idea why I had the reaction I did, other than it was basically an overdose that had a severe effect on me. I am slowly finding other complaints about this med on the web, though none quite as bad as what has happened to me. Janee Gillette gave it to me for heavy mentrual cycle, NOT what it is indicated for what so ever! I have contacted Exodus with my complaint and story about this, and they have not responded what so ever. http://www.dr-bob.org/babble/20090203/msgs/878245.html
Event date: Friday November 7th 12:00:00 AM
Dosage: 7.5 mgs
Frequency: once
Age: 41
Weight: 110
Other medications: diazepam (low dose)
Diagnosis: Given to me by a pa Janee Gillette of Exodus Healthcare WVC UTAH, off label. She said it was for heavy mentrual cycle, a COMPLETE LIE! Pamlab makes Deplin. And they dont have to answer to anyone, although Deplin only available by prescription (or sample from your doctors office as in my case) it is NOT FDA approved! It IS NOT really any form of regular Folic Acid in any way shape or form! It is L methylfolate! It does not have to be broken down by the body at all. It goes directly to the brain! It effects all brain chemicals, and according to the pharmacology, which is hard to find by the way, there are adverse reactions. However the company refuses to tell me what those are! They said they dont have to, because they dont have to answer to the FDA! It is basically an overdose of a much stronger form of folic acid, and it is not water soluable either, it is 52 percent plasma protien binding, enough time to stay in your system to cause damage, as it did to me. Pamlab refused to help me when I called them within days of my reaction, and they have refused to connect me with their legal dept. or give me the number to contact them. Blood tests are supposed to be done before being given to patients, but I guess the pa Janee Gillette at the Exodus Healthcare in WVC (Part of Magna Center for Families Medical) simply didnt care, or investigate to know enough about this DRUG and what it was for. She said it was for heavy mentrual cycle. A complete lie! She did no blood tests prior to giving it to me. I was not defiecient in folic acid as a patient would need to be to have this prescribed in the first place! Nor did she care to investigate that is was not supposed to be given to patients with seizure disorders or on anticonvulsants, as I was. But, on the little pamplet, it said NO SIDE EFFECTS or interactions! PAMLAB lies, and they dont care and they dont have to answer to anyone. I plan to get a lawyer and sue both the pa, the health care center, and Pamlab. I have no idea why I had the reaction I did, other than it was basically an overdose that had a severe effect on me. I am slowly finding other complaints about this med on the web, though none quite as bad as what has happened to me. Janee Gillette gave it to me for heavy mentrual cycle, NOT what it is indicated for what so ever! I have contacted Exodus with my complaint and story about this, and they have not responded what so ever. http://www.dr-bob.org/babble/20090203/msgs/878245.html
Pre-existing conditions: smoking, tle, acid reflux
Hospitalized? No
Life-threatening? No
Disabled? Yes
Birth Defects? No
Was intervention required to prevent damage? No
Other serious medical events? Yes
Died? No
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